Role of cited-1 and caspase-6 expression in HELLP syndrome

Role of cited-1 and caspase-6 expression in HELLP syndrome

In this study, we investigated the immunohistochemical staining of cited-1 and caspase-6 expression in the placentas of pregnant women with HELLP syndrome. Placentas of 20 normotensive patients and 20 women with HELLP syndrome were processed for routine histological tissue processing. The biochemica...

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Bibliographic Details
Published in:European review for medical and pharmacological sciences Vol. 27; no. 7; p. 3082
Main Authors: Öcal, E, Alkan Akalın, S, Aşır, F
Format: Journal Article
Language:English
Published: Italy 01-04-2023
Subjects:
Blood Pressure
Caspase 6 - analysis
Caspase 6 - metabolism
Endothelial Cells - metabolism
Female
HELLP Syndrome - metabolism
HELLP Syndrome - pathology
Humans
Placenta - metabolism
Pre-Eclampsia - pathology
Pregnancy
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Summary:In this study, we investigated the immunohistochemical staining of cited-1 and caspase-6 expression in the placentas of pregnant women with HELLP syndrome. Placentas of 20 normotensive patients and 20 women with HELLP syndrome were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and cited-1 and caspase-6 immunostaining. Placentas of normotensive patients showed normal histology. Placentas of women with HELLP syndrome showed degenerated cells, hyalinization and vacuolization. Cited-1 expression was negative in normotensive group; however, it was increased in HELLP group, especially in decidual cells, endothelial cells and other placental cells. Caspase-6 expression was negative in placental structures of normotensive groups. However, it was intense in decidual cells, vacuolar and hyalinized areas, inflammatory cells and connective tissue cells in HELLP group. Cited-1 and caspase-6 are a marker in determining the severity of HELLP syndrome.
ISSN:2284-0729