Search Results - "Aljamali, Majed N."

Successful treatment of canine hemophilia by continuous expression of canine FVIIa by Margaritis, Paris, Roy, Elise, Aljamali, Majed N., Downey, Harre D., Giger, Urs, Zhou, Shangzhen, Merricks, Elizabeth, Dillow, Aaron, Ezban, Mirella, Nichols, Timothy C., High, Katherine A.

“…Continuous expression of activated factor VII (FVIIa) via gene transfer is a potential therapeutic approach for hemophilia patients with or without inhibitory…”
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Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality by Aljamali, Majed N, Margaritis, Paris, Schlachterman, Alexander, Tai, Shing Jen, Roy, Elise, Bunte, Ralph, Camire, Rodney M, High, Katherine A

“…Intravenous infusion of recombinant human activated Factor VII (FVIIa) has been used for over a decade in the successful management of bleeding episodes in…”
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66. Gene Transfer-Mediated Expression of Murine Factor VIIa Improves Clot Formation in a Mouse Model for Bernard-Soulier Syndrome by Aljamali, Majed N., Margaritis, Paris, Arruda, Valder R., Schlachterman, Alex, Dunn, Danielle, Ware, Jerry, High, Katherine A.

“…Moderate to severe bleeding occurs in Bernard-Soulier syndrome (BSS) patients due to a rare inherited dysfunction of their platelet GPIbα/β-IX-V receptor, a…”
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Lessons from Transgenic Mice Expressing Supra-Physiological Levels of Activated Murine Factor VII by Aljamali, Majed N., Margaritis, Paris, Camire, Rodney, High, Katherine A.

“…A gene transfer approach using an engineered activated murine FVII (mVIIa) has previously shown efficacy in correcting the bleeding diathesis of hemophilia B…”
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Successful and Safe Treatment of Canine Hemophilia by Continuous Expression of Canine FVIIa: a Model for FVIII/FIX Gene-Based Bypassing Agents by Margaritis, Paris, Roy, Elise, Aljamali, Majed N, Downey, Harre, Zhou, Shangzhen, Merricks, Elizabeth, Dillow, Aaron, Nichols, Timothy C, High, Katherine A.

“…Recombinant human activated Factor VII (rhFVIIa) is extensively used in the management of hemophilic inhibitor patients. However, the short plasma half-life…”
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Generation of Transgenic Mice Expressing High Levels of Activated Murine Coagulation Factor VII by Aljamali, Majed N., Margaritis, Paris, Schlachterman, Alexander, High, Katherine A.

“…Treatment of acute bleeding episodes in hemophilic patients with inhibitors can be successfully managed by the infusion of recombinant human factor VIIa…”
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606. Molecular Characterization of Hereditary Factor VII Deficiency in Beagles by Aljamali, Majed N, Callan, Mary Beth, Pollak, Eleanor S, Giger, Urs, Werner, Petra, Griot-wenk, Monika, High, Katherine A

“…Hereditary factor VII deficiency is the most common autosomal recessive inherited factor deficiency. Several mutations in the coding sequence of the human…”
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32. Efficacy and Safety of Mouse Coagulation Factor VIIa Gene Transfer in Hemophilia B Mice by Aljamali, Majed N, Margaritis, Paris, Arruda, Valder R, Schlachterman, Alexander, Camire, Rodney M, High, Katherine A

“…One major complication of replacement therapy with clotting factors in patients with hemophilia A and B is the development of inhibitory antibodies that…”
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