Search Results - "Aljaibeji, Hayat"
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Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients
Published in International journal of molecular sciences (17-05-2021)“…The global coronavirus disease 2019 (COVID-19) pandemic was associated with multiple organ failure and comorbidities, such as type 2 diabetes mellitus (T2DM)…”
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Profiling Levels of Serum microRNAs and Soluble ACE2 in COVID-19 Patients
Published in Life (Basel, Switzerland) (12-04-2022)“…The main mechanism of viral entry in COVID-19 infection is through the angiotensin-converting enzyme 2 (ACE2) receptor present in the lungs. Numerous studies…”
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Reduced Expression of PLCXD3 Associates With Disruption of Glucose Sensing and Insulin Signaling in Pancreatic β-Cells
Published in Frontiers in endocrinology (Lausanne) (06-11-2019)“…Previous work has shown that reduced expression of PLCXD3 , a member of the phosphoinositide-specific phospholipases (PI-PLC) family, impaired insulin…”
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Abstract 009: A Genetic Variant Of Regulatory Associated Protein Of Mtor Complex 1 (raptor) Is Associated With Blood Pressure
Published in Hypertension (Dallas, Tex. 1979) (01-09-2022)“…Abstract only Background: The regulatory associated protein of mTOR complex I (Raptor) is essential for the activity of the mTOR1 complex. Clinical and…”
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GNAS gene is an important regulator of insulin secretory capacity in pancreatic β-cells
Published in Gene (05-10-2019)“…Type 2 diabetes (T2D) is a complex polygenic disease with unclear mechanism. In an attempt to identify novel genes involved in β-cell function, we harness a…”
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Abstract P140: Impact Of Ovariectomy On Aldosterone And Blood Pressure In Lysine-Specific Demethylase 1 (LSD1) Deficient Mice
Published in Hypertension (Dallas, Tex. 1979) (01-09-2023)“…Abstract only LSD1 regulates steroid receptor function including estrogen and mineralocorticoid receptor. Women of African descent who carry the LSD1 risk…”
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Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population
Published in Hypertension (Dallas, Tex. 1979) (01-05-2024)“…The mTOR (mechanistic target of rapamycin) is an essential regulator of fundamental biological processes. mTOR forms 2 distinct complexes, mTORC1 (mTOR complex…”
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Prediabetes and diabetes prevalence and risk factors comparison between ethnic groups in the United Arab Emirates
Published in Scientific reports (25-11-2019)“…The economic growth has paralleled the rise of diabetes and its complications in multiethnic population of United Arab Emirates (UAE). Previous studies have…”
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Let7b-5p is Upregulated in the Serum of Emirati Patients with Type 2 Diabetes and Regulates Insulin Secretion in INS-1 Cells
Published in Experimental and clinical endocrinology & diabetes (01-01-2022)“…is a member of the miRNA family and one of the top expressed miRNAs in human islets that implicated in glucose homeostasis. The levels of in type 2 diabetes…”
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Effect of Troglitazone (Tz) and N‐Acetyl Cysteine (Nac) Treatment on Beta Cells' Survival, and Insulin Production Under Hyperglycaemic Conditions
Published in The FASEB journal (01-04-2018)“…Background Type I diabetes mellitus is characterized by the deficiency of insulin‐producing beta cells but there is still a substantial number of beta cells…”
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FRI141 Dietary Salt Regulates mTORC1 Signaling In Humans And Mice With Hypertension
Published in Journal of the Endocrine Society (05-10-2023)“…Abstract Disclosure: H. Aljaibeji: None. D.L. Brooks: None. A.E. Garza: None. P. Gerges: None. M. Heydarpour: None. P. Luminita: None. J.S. Williams: None. G…”
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An Integrative Phenotype-Genotype Approach Using Phenotypic Characteristics from the UAE National Diabetes Study Identifies HSD17B12 as a Candidate Gene for Obesity and Type 2 Diabetes
Published in Genes (23-04-2020)“…The United Arab Emirates National Diabetes and Lifestyle Study (UAEDIAB) has identified obesity, hypertension, obstructive sleep apnea, and dyslipidemia as…”
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Genetic Variants of the PLCXD3 Gene Are Associated with Risk of Metabolic Syndrome in the Emirati Population
Published in Genes (18-06-2020)“…Phosphatidylinositol-specific phospholipase C X domain 3 has been shown to influence pancreatic β-cell function by disrupting insulin signaling. Herein, we…”
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