Search Results - "Aliuska Morales Helguera"

Biodegradation of Crystalline Cellulose Nanofibers by Means of Enzyme Immobilized-Alginate Beads and Microparticles by Kamdem Tamo, Arnaud, Doench, Ingo, Morales Helguera, Aliuska, Hoenders, Daniel, Walther, Andreas, Madrazo, Anayancy Osorio

“…Recent advances in nanocellulose technology have revealed the potential of crystalline cellulose nanofibers to reinforce materials which are useful for tissue…”
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Antileishmanial activity of 5-nitroindazole derivatives by Mollineda-Diogo, Niurka, Chaviano-Montes de Oca, Claudia Sissely, Sifontes-Rodríguez, Sergio, Espinosa-Buitrago, Teresa, Monzote-Fidalgo, Lianet, Meneses-Marcel, Alfredo, Morales-Helguera, Aliuska, Perez-Castillo, Yunierkis, Arán-Redó, Vicente

“…Background: Currently, there is no safe and effective vaccine against leishmaniasis and existing therapies are inadequate due to high toxicity, cost and…”
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Efficient and biologically relevant consensus strategy for Parkinson's disease gene prioritization by Cruz-Monteagudo, Maykel, Borges, Fernanda, Paz-Y-Miño, Cesar, Cordeiro, M Natália D S, Rebelo, Irene, Perez-Castillo, Yunierkis, Helguera, Aliuska Morales, Sánchez-Rodríguez, Aminael, Tejera, Eduardo

“…The systemic information enclosed in microarray data encodes relevant clues to overcome the poorly understood combination of genetic and environmental factors…”
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Application of the replacement method as novel variable selection in QSPR. 2. Soil sorption coefficients by Duchowicz, Pablo R., González, Maykel Pérez, Helguera, Aliuska Morales, Natália Dias Soeiro Cordeiro, Maria, Castro, Eduardo A.

“…We predict the soil sorption coefficients of 163 non-ionic organic pesticides performing a QSPR treatment. A pool containing 1247 theoretical descriptors is…”
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Quantitative structure activity relationships as useful tools for the design of new adenosine receptor ligands. 1. Agonist by González, Maykel Pérez, Terán, Carmen, Teijeira, Marta, Helguera, Aliuska Morales

“…In order to minimize expensive drug failures it is essential to determine the potential biological activity of new candidates as early as possible. In view of…”
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Validation of venous thromboembolism predictive model in hematologic malignancies by López Sacerio, Agnerys, Tejeda Ramón, Mara Caridad, Morales Helguera, Aliuska, Pérez Castillo, Yunierkis, Cruz Rodríguez, Javier, Guerra Rodríguez, Jorge Felix, Falanga, Anna

“…Although several scores stratify venous thromboembolism (VTE) risk in solid tumors, hematologic malignancies (HM) are underrepresented. To develop an internal…”
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A radial-distribution-function approach for predicting rodent carcinogenicity by Morales, Aliuska Helguera, Cabrera Pérez, Miguel Angel, González, Maykel Pérez

“…Carcinogenic activity has been investigated using the Radial-Distribution-Function (RDF) approach. A discriminant model was developed to predict the…”
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Classifier Ensemble Based on Feature Selection and Diversity Measures for Predicting the Affinity of A2B Adenosine Receptor Antagonists by Bonet, Isis, Franco-Montero, Pedro, Rivero, Virginia, Teijeira, Marta, Borges, Fernanda, Uriarte, Eugenio, Morales Helguera, Aliuska

“…A2B adenosine receptor antagonists may be beneficial in treating diseases like asthma, diabetes, diabetic retinopathy, and certain cancers. This has stimulated…”
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Fuzzy clustering as rational partition method for QSAR by Pérez-Garrido, Alfonso, Girón-Rodríguez, Francisco, Bueno-Crespo, Andrés, Soto, Jesús, Pérez-Sánchez, Horacio, Helguera, Aliuska Morales

“…Various methods are used to make the partition of data sets for QSAR development and model validation. In this work we used a fuzzy minimals partitioning and…”
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Two New Parameters Based on Distances in a Receiver Operating Characteristic Chart for the Selection of Classification Models by Pérez-Garrido, Alfonso, Helguera, Aliuska Morales, Borges, Fernanda, Cordeiro, M. Natália D. S, Rivero, Virginia, Escudero, Amalio Garrido

“…There are several indices that provide an indication of different types on the performance of QSAR classification models, being the area under a Receiver…”
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Topological sub-structural molecular design approach: Radical scavenging activity by Pérez-Garrido, Alfonso, Helguera, Aliuska Morales, Morillas Ruiz, Juana M., Zafrilla Rentero, Pilar

“…In the last decades phenolic compounds have gained enormous interest because of their beneficial health effects such as anti-inflammatory, anticancer, or…”
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Combining molecular docking and QSAR studies for modelling the antigyrase activity of cyclothialidine derivatives by Saíz-Urra, Liane, Cabrera Pérez, Miguel Ángel, Helguera, Aliuska Morales, Froeyen, Matheus

“…DNA gyrase is a well-established antibacterial target consisting of two subunits, GyrA and GyrB, in a heterodimer A 2B 2, where GyrB catalyzes the hydrolysis…”
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QSAR models to predict mutagenicity of acrylates, methacrylates and α , β -unsaturated carbonyl compounds by Pérez-Garrido, Alfonso, Helguera, Aliuska Morales, Rodríguez, Francisco Girón, Cordeiro, M.Natália D.S

“…Abstract Objective The purpose of this study is to develop a quantitative structure–activity relationship (QSAR) model that can distinguish mutagenic from…”
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Chemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A2AAR Dual Binding Scaffold by Cruz Monteagudo, Maykel, Borges, Fernanda, Cordeiro, M Natália D S, Helguera, Aliuska Morales, Tejera, Eduardo, Paz y Miño, Cesar, Sánchez Rodríguez, Aminael, Perera Sardiña, Yunier, Perez Castillo, Yunierkis

“…Background: In the context of the current drug discovery efforts to find disease modifying therapies for Parkinson's disease (PD) the current single target…”
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Quantitative structure–activity relationship to predict differential inhibition of aldose reductase by flavonoid compounds by Fernández, Michael, Caballero, Julio, Helguera, Aliuska Morales, Castro, Eduardo A., González, Maykel Pérez

“…[Display omitted] Inhibitory activity against aldose reductase enzyme of flavonoid derivatives were modelled using 11 kinds of molecular descriptors from…”
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QSPR modelling with the topological substructural molecular design approach: beta-cyclodextrin complexation by Pérez-Garrido, Alfonso, Helguera, Aliuska Morales, Cordeiro, M Natália D S, Escudero, Amalio Garrido

“…This study aims at developing a quantitative structure-property relationship (QSPR) model for predicting complexation with beta-cyclodextrins (beta-CD) based…”
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Quantitative Structure−Carcinogenicity Relationship for Detecting Structural Alerts in Nitroso Compounds: Species, Rat; Sex, Female; Route of Administration, Gavage by Morales Helguera, Aliuska, Pérez González, Maykel, Dias Soeiro Cordeiro, Maria Natália, Cabrera Pérez, Miguel Ángel

“…Chemical carcinogenicity is of primary interest because it drives much of the current regulatory actions regarding new and existing chemicals and conventional…”
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A topological substructural molecular design approach for predicting mutagenesis end-points of α , β -unsaturated carbonyl compounds by Pérez-Garrido, Alfonso, Helguera, Aliuska Morales, López, Gabriel Caravaca, Cordeiro, M.Natália D.S, Escudero, Amalio Garrido

“…Abstract Chemically reactive, α , β -unsaturated carbonyl compounds are common environmental pollutants able to produce a wide range of adverse effects,…”
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Quantitative structure carcinogenicity relationship for detecting structural alerts in nitroso-compounds Species : Rat; Sex: Male; Route of administration: Water by MORALES HELGUERA, Aliuska, CORDEIRO, M. Natalia D. S, CABRERA PEREZ, Miguel Angel, COMBES, Robert D, PEREZ GONZALEZ, Maykel

“…In this work, Quantitative Structure-Activity Relationship (QSAR) modelling was used as a tool for predicting the carcinogenic potency of a set of 39…”
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Quantitative structure carcinogenicity relationship for detecting structural alerts in nitroso-compounds by Helguera, Aliuska Morales, González, Maykel Pérez, D. S. Cordeiro, Maria Natália, Pérez, Miguel Ángel Cabrera

“…Prevention of environmentally induced cancers is a major health problem of which solutions depend on the rapid and accurate screening of potential chemical…”
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