Search Results - "Alison Burgess"

Focused ultrasound-mediated drug delivery through the blood-brain barrier by Burgess, Alison, Shah, Kairavi, Hough, Olivia, Hynynen, Kullervo

“…Despite recent advances in blood-brain barrier (BBB) research, it remains a significant hurdle for the pharmaceutical treatment of brain diseases. Focused…”
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Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior by Burgess, Alison, Dubey, Sonam, Yeung, Sharon, Hough, Olivia, Eterman, Naomi, Aubert, Isabelle, Hynynen, Kullervo

“…To validate whether repeated magnetic resonance (MR) imaging-guided focused ultrasound treatments targeted to the hippocampus, a brain structure relevant for…”
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Analysis of focused ultrasound-induced blood–brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy by Burgess, Alison, Nhan, Tam, Moffatt, Clare, Klibanov, A.L., Hynynen, Kullervo

“…Transcranial focused ultrasound (FUS) can cause temporary, localized increases in blood–brain barrier (BBB) permeability for effective drug delivery to the…”
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Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier by Burgess, Alison, Ayala-Grosso, Carlos A, Ganguly, Milan, Jordão, Jessica F, Aubert, Isabelle, Hynynen, Kullervo

“…Stem cell therapy is a promising strategy to treat neurodegenerative diseases, traumatic brain injury, and stroke. For stem cells to progress towards clinical…”
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Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability by Mooney, Skyler J, Shah, Kairavi, Yeung, Sharon, Burgess, Alison, Aubert, Isabelle, Hynynen, Kullervo

“…Transcranial focused ultrasound technology used to transiently open the blood-brain barrier, is capable of stimulating hippocampal neurogenesis; however, it is…”
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Drug delivery to the brain by focused ultrasound induced blood–brain barrier disruption: Quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy by Nhan, Tam, Burgess, Alison, Cho, Eunice E., Stefanovic, Bojana, Lilge, Lothar, Hynynen, Kullervo

“…Reversible and localized blood–brain barrier disruption (BBBD) using focused ultrasound (FUS) in combination with intravascularly administered microbubbles…”
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31 A no-brainer, or is it? by Burgess, Alison, Carson, Amy

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High-intensity focused ultrasound (HIFU) for dissolution of clots in a rabbit model of embolic stroke by Burgess, Alison, Huang, Yuexi, Waspe, Adam C, Ganguly, Milan, Goertz, David E, Hynynen, Kullervo

“…It is estimated that only 2-6% of patients receive thrombolytic therapy for acute ischemic stroke suggesting that alternative therapies are necessary. In this…”
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Transposition of hAT elements links transposable elements and V(D)J recombination by Zhou, L, Mitra, R, Atkinson, P.W, Hickman, A.B, Dyda, F, Craig, N.L

“…Transposons are DNA sequences that encode functions that promote their movement to new locations in the genome. If unregulated, such movement could potentially…”
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Mechanism of IS200/IS605 family DNA transposases: activation and transposon-directed target site selection by Barabas, Orsolya, Ronning, Donald R, Guynet, Catherine, Hickman, Alison Burgess, Ton-Hoang, Bao, Chandler, Michael, Dyda, Fred

“…The smallest known DNA transposases are those from the IS200/IS605 family. Here we show how the interplay of protein and DNA activates TnpA, the Helicobacter…”
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The Amino Acid Linker between the Endonuclease and Helicase Domains of Adeno-Associated Virus Type 5 Rep Plays a Critical Role in DNA-Dependent Oligomerization by MAGGIN, Jenna E, JAMES, Jeffrey A, CHAPPIE, Joshua S, DYDA, Fred, BURGESS HICKMAN, Alison

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Single-Stranded DNA Transposition Is Coupled to Host Replication by Ton-Hoang, Bao, Pasternak, Cécile, Siguier, Patricia, Guynet, Catherine, Hickman, Alison Burgess, Dyda, Fred, Sommer, Suzanne, Chandler, Michael

“…DNA transposition has contributed significantly to evolution of eukaryotes and prokaryotes. Insertion sequences (ISs) are the simplest prokaryotic transposons…”
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Polysialic acid regulates the clustering, migration, and neuronal differentiation of progenitor cells in the adult hippocampus by Burgess, Alison, Wainwright, Steven R., Shihabuddin, Lamya S., Rutishauser, Urs, Seki, Tatsunori, Aubert, Isabelle

“…Newborn cells of the adult dentate gyrus in the hippocampus are characterized by their abundant expression of polysialic acid (PSA), a carbohydrate attached to…”
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Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System by Burgess, Alison, Hynynen, Kullervo

“…The blood-brain barrier is a serious impediment to the delivery of pharmaceutical treatments for brain diseases, including cancer, neurodegenerative and…”
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Drug delivery across the blood-brain barrier using focused ultrasound by Burgess, Alison, Hynynen, Kullervo

“…The presence of the blood-brain barrier (BBB) is a significant impediment to the delivery of therapeutic agents to the brain for treatment of brain diseases…”
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The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA by Ronning, Donald R, Li, Ying, Perez, Zhanita N, Ross, Philip D, Hickman, Alison Burgess, Craig, Nancy L, Dyda, Fred

“…Tn7 transposition requires the assembly of a nucleoprotein complex containing four self‐encoded proteins, transposon ends, and target DNA. Within this complex,…”
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Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival by Alkins, Ryan, Burgess, Alison, Kerbel, Robert, Wels, Winfried S, Hynynen, Kullervo

“…Malignant brain tumors have a dismal prognosis, with residual tumor remaining after surgery necessitating adjuvant chemoradiotherapy. The blood-brain barrier…”
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High-Intensity Focused Ultrasound Sonothrombolysis: The Use of Perfluorocarbon Droplets to Achieve Clot Lysis at Reduced Acoustic Power by Pajek, Daniel, Burgess, Alison, Huang, Yuexi, Hynynen, Kullervo

“…Abstract The purpose of this study was to evaluate use of intravascular perfluorocarbon droplets to reduce the sonication power required to achieve clot lysis…”
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Focused Ultrasound Delivers Targeted Immune Cells to Metastatic Brain Tumors by ALKINS, Ryan, BURGESS, Alison, GANGULY, Milan, FRANCIA, Giulio, KERBEL, Robert, WELS, Winfried S, HYNYNEN, Kullervo

“…Natural killer (NK) cells are cytotoxic lymphocytes involved in innate immunity. NK-92, a human NK cell line, may be targeted to tumor-associated antigens in…”
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Insertion Sequence IS26 Reorganizes Plasmids in Clinically Isolated Multidrug-Resistant Bacteria by Replicative Transposition by He, Susu, Hickman, Alison Burgess, Varani, Alessandro M, Siguier, Patricia, Chandler, Michael, Dekker, John P, Dyda, Fred

“…Carbapenemase-producing Enterobacteriaceae (CPE), which are resistant to most or all known antibiotics, constitute a global threat to public health…”
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