Search Results - "Alison, Murdoch"

Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease by Hyslop, Louise A., Blakeley, Paul, Craven, Lyndsey, Richardson, Jessica, Fogarty, Norah M. E., Fragouli, Elpida, Lamb, Mahdi, Wamaitha, Sissy E., Prathalingam, Nilendran, Zhang, Qi, O’Keefe, Hannah, Takeda, Yuko, Arizzi, Lucia, Alfarawati, Samer, Tuppen, Helen A., Irving, Laura, Kalleas, Dimitrios, Choudhary, Meenakshi, Wells, Dagan, Murdoch, Alison P., Turnbull, Douglass M., Niakan, Kathy K., Herbert, Mary

“…Preclinical evaluation and optimization of mitochondrial replacement therapy reveals that a modified form of pronuclear transfer is likely to give rise to…”
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Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease by Herbert, Mary, Turnbull, Douglass M, Craven, Lyndsey, Tuppen, Helen A, Greggains, Gareth D, Harbottle, Stephen J, Murphy, Julie L, Cree, Lynsey M, Murdoch, Alison P, Chinnery, Patrick F, Taylor, Robert W, Lightowlers, Robert N

“…Mutations in mitochondrial DNA (mtDNA) are a common cause of genetic disease. Pathogenic mutations in mtDNA are detected in approximately 1 in 250 live births…”
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Human Epidermal Neural Crest Stem Cells (hEPI-NCSC)—Characterization and Directed Differentiation into Osteocytes and Melanocytes by Clewes, Oliver, Narytnyk, Alla, Gillinder, Kevin R., Loughney, Andrew D., Murdoch, Alison P., Sieber-Blum, Maya

“…Here we describe the isolation, characterisation and ex-vivo expansion of human epidermal neural crest stem cells (hEPI-NCSC) and we provide protocols for…”
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Downregulation of NANOG Induces Differentiation of Human Embryonic Stem Cells to Extraembryonic Lineages by Hyslop, Louise, Stojkovic, Miodrag, Armstrong, Lyle, Walter, Theresia, Stojkovic, Petra, Przyborski, Stefan, Herbert, Mary, Murdoch, Alison, Strachan, Tom, Lako, Majlinda

“…The homeobox transcription factor Nanog has been proposed to play a crucial role in the maintenance of the undifferentiated state of murine embryonic stem…”
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Evaluation of epigenetic marks in human embryos derived from IVF and ICSI by Santos, Fátima, Hyslop, Louise, Stojkovic, Petra, Leary, Christine, Murdoch, Alison, Reik, Wolf, Stojkovic, Miodrag, Herbert, Mary, Dean, Wendy

“…BACKGROUND It has long been appreciated that environmental cues may trigger adaptive responses. Many of these responses are a result of changes in the…”
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Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes by Homer, Hayden A, McDougall, Alex, Levasseur, Mark, Yallop, Katie, Murdoch, Alison P, Herbert, Mary

“…In mitosis, the spindle checkpoint protein Mad2 averts aneuploidy by delaying anaphase onset until chromosomes align. Here we show that depletion of Mad2 in…”
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To freeze or not to freeze embryos: clarity, confusion and conflict by Goswami, Mohar, Murdoch, Alison P., Haimes, Erica

“…Abstract Although embryo freezing is a routine clinical practice, there is little contemporary evidence on how couples make the decision to freeze their…”
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Mitochondrial DNA disease: new options for prevention by CRAVEN, Lyndsey, ELSON, Joanna L, IRVING, Laura, TUPPEN, Helen A, LISTER, Lisa M, GREGGAINS, Gareth D, BYERLEY, Samantha, MURDOCH, Alison P, HERBERT, Mary, TURNBULL, Doug

“…Very recently, two papers have presented intriguing data suggesting that prevention of transmission of human mitochondrial DNA (mtDNA) disease is possible…”
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Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1 by Herbert, Mary, McDougall, Alex, Levasseur, Mark, Homer, Hayden, Yallop, Katie, Murdoch, Alison

“…Disjunction of pairs of homologous chromosomes during the first meiotic division (MI) requires anaphase-promoting complex (APC)-mediated activation of separase…”
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Putative Role of Hyaluronan and Its Related Genes, HAS2 and RHAMM, in Human Early Preimplantation Embryogenesis and Embryonic Stem Cell Characterization by Choudhary, Meenakshi, Zhang, Xin, Stojković, Petra, Hyslop, Louise, Anyfantis, George, Herbert, Mary, Murdoch, Alison P., Stojković, Miodrag, Lako, Majlinda

“…Human embryonic stem cells (hESC) promise tremendous potential as a developmental and cell therapeutic tool. The combined effort of stimulatory and inhibitory…”
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Surgeons and scientists: Working together in embryo research by Murdoch, Alison P.

“…Most surgeons in academic hospitals will have had a request from an enthusiastic research scientist to take samples of tissue during an operation. It seems…”
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Derivation, growth and applications of human embryonic stem cells by Stojkovic, Miodrag, Lako, Majlinda, Strachan, Tom, Murdoch, Alison

“…Human embryonic stem (hES) cells are pluripotent cells derived from the inner cell mass cells of blastocysts with the potential to maintain an undifferentiated…”
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Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes by Homer, Hayden A, McDougall, Alex, Levasseur, Mark, Murdoch, Alison P, Herbert, Mary

“…Mad2 is a pivotal component of the spindle assembly checkpoint (SAC) which inhibits anaphase promoting complex/cyclo-some (APC/C) activity by sequestering…”
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Nuclear transfer and iPS may work best together by Gurdon, John, Murdoch, Alison

“…A short meeting, held as an Arthur Sackler Colloquium of the United States National Academy of Sciences, was organized by Douglas Wallace, Susan Bryant, and…”
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Derivation of Human Embryonic Stem Cells from Day‐8 Blastocysts Recovered after Three‐Step In Vitro Culture by Stojkovic, Miodrag, Lako, Majlinda, Stojkovic, Petra, Stewart, Rebecca, Przyborski, Stefan, Armstrong, Lyle, Evans, Jerry, Herbert, Mary, Hyslop, Louise, Ahmad, Sajjad, Murdoch, Alison, Strachan, Tom

“…Human embryonic stem cells (hESCs) have been derived from the inner cell mass (ICM) of day 5–7 blastocysts and hold great promise for research into human…”
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Corrigendum: Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease by Hyslop, Louise A, Blakeley, Paul, Craven, Lyndsey, Richardson, Jessica, Fogarty, Norah M E, Fragouli, Elpida, Lamb, Mahdi, Wamaitha, Sissy E, Prathalingam, Nilendran, Zhang, Qi, O'Keefe, Hannah, Takeda, Yuko, Arizzi, Lucia, Alfarawati, Samer, Tuppen, Helen A, Irving, Laura, Kalleas, Dimitrios, Choudhary, Meenakshi, Wells, Dagan, Murdoch, Alison P, Turnbull, Douglass M, Niakan, Kathy K, Herbert, Mary

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Derivation of a human blastocyst after heterologous nuclear transfer to donated oocytes by Miodrag, Stojkovic, Petra, Stojkovic, Christine, Leary, Vanessa, Jane Hall, Lyle, Armstrong, Mary, Herbert, Maria, Nesbitt, Majlinda, Lako, Alison, Murdoch

“…This paper describes the derivation of a blastocyst following heterologous nuclear transfer (NT) into a human oocyte. It also demonstrates that a major…”
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Therapeutic potential of somatic cell nuclear transfer for degenerative disease caused by mitochondrial DNA mutations by Greggains, Gareth D., Lister, Lisa M., Tuppen, Helen A. L., Zhang, Qi, Needham, Louise H., Prathalingam, Nilendran, Hyslop, Louise A., Craven, Lyndsey, Polanski, Zbigniew, Murdoch, Alison P., Turnbull, Douglass M., Herbert, Mary

“…Induced pluripotent stem cells (iPSCs) hold much promise in the quest for personalised cell therapies. However, the persistence of founder cell mitochondrial…”
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Relaxin has a role in establishing a renal response in pregnancy by Smith, Marie C, Murdoch, Alison P, Danielson, Lee A, Conrad, Kirk P, Davison, John M

“…Women with normal ovarian function (n = 9) and women who conceived with ovum donation (no circulating relaxin; n = 9) had serial measurements of renal function…”
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A novel isolator-based system promotes viability of human embryos during laboratory processing by Hyslop, Louise, Prathalingam, Nilendran, Nowak, Lynne, Fenwick, Jeanette, Harbottle, Steve, Byerley, Samantha, Rhodes, John, Watson, Bruce, Henderson, Robin, Murdoch, Alison, Herbert, Mary

“…In vitro fertilisation (IVF) and related technologies are arguably the most challenging of all cell culture applications. The starting material is a single…”
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