Search Results - "Aliper, Alex"

Artificial intelligence for aging and longevity research: Recent advances and perspectives by Zhavoronkov, Alex, Mamoshina, Polina, Vanhaelen, Quentin, Scheibye-Knudsen, Morten, Moskalev, Alexey, Aliper, Alex

“…The applications of modern artificial intelligence (AI) algorithms within the field of aging research offer tremendous opportunities. Aging is an almost…”
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Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities by Galkin, Fedor, Mamoshina, Polina, Aliper, Alex, de Magalhães, João Pedro, Gladyshev, Vadim N., Zhavoronkov, Alex

“…[Display omitted] Telomere length, gene expression, blood chemical parameters and DNA-methylation status all undergo age-associated changes, which can be…”
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AlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor by Ren, Feng, Ding, Xiao, Zheng, Min, Korzinkin, Mikhail, Cai, Xin, Zhu, Wei, Mantsyzov, Alexey, Aliper, Alex, Aladinskiy, Vladimir, Cao, Zhongying, Kong, Shanshan, Long, Xi, Man Liu, Bonnie Hei, Liu, Yingtao, Naumov, Vladimir, Shneyderman, Anastasia, Ozerov, Ivan V, Wang, Ju, Pun, Frank W, Polykovskiy, Daniil A, Sun, Chong, Levitt, Michael, Aspuru-Guzik, Alán, Zhavoronkov, Alex

“…The application of artificial intelligence (AI) has been considered a revolutionary change in drug discovery and development. In 2020, the AlphaFold computer…”
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Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning by Galkin, Fedor, Mamoshina, Polina, Aliper, Alex, Putin, Evgeny, Moskalev, Vladimir, Gladyshev, Vadim N., Zhavoronkov, Alex

“…The human gut microbiome is a complex ecosystem that both affects and is affected by its host status. Previous metagenomic analyses of gut microflora revealed…”
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High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders by Mkrtchyan, Garik V., Veviorskiy, Alexander, Izumchenko, Evgeny, Shneyderman, Anastasia, Pun, Frank W., Ozerov, Ivan V., Aliper, Alex, Zhavoronkov, Alex, Scheibye-Knudsen, Morten

“…Multiple cancer types have limited targeted therapeutic options, in part due to incomplete understanding of the molecular processes underlying tumorigenesis…”
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COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity by Naumov, Vladimir, Putin, Evgeny, Pushkov, Stefan, Kozlova, Ekaterina, Romantsov, Konstantin, Kalashnikov, Alexander, Galkin, Fedor, Tihonova, Nina, Shneyderman, Anastasia, Galkin, Egor, Zinkevich, Arsenii, Cope, Stephanie M, Sethuraman, Ramanathan, Oprea, Tudor I, Pearson, Alexander T, Tay, Savas, Agrawal, Nishant, Dubovenko, Alexey, Vanhaelen, Quentin, Ozerov, Ivan, Aliper, Alex, Izumchenko, Evgeny, Zhavoronkov, Alex

“…Coronavirus disease 2019 (COVID-19) is an acute infection of the respiratory tract that emerged in December 2019 in Wuhan, China. It was quickly established…”
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Quantum-assisted fragment-based automated structure generator (QFASG) for small molecule design: an in vitro study by Evteev, Sergei, Ivanenkov, Yan, Semenov, Ivan, Malkov, Maxim, Mazaleva, Olga, Bodunov, Artem, Bezrukov, Dmitry, Sidorenko, Denis, Terentiev, Victor, Malyshev, Alex, Zagribelnyy, Bogdan, Korzhenevskaya, Anastasia, Aliper, Alex, Zhavoronkov, Alex

“…The significance of automated drug design using virtual generative models has steadily grown in recent years. While deep learning-driven solutions have…”
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druGAN: An Advanced Generative Adversarial Autoencoder Model for de Novo Generation of New Molecules with Desired Molecular Properties in Silico by Kadurin, Artur, Nikolenko, Sergey, Khrabrov, Kuzma, Aliper, Alex, Zhavoronkov, Alex

“…Deep generative adversarial networks (GANs) are the emerging technology in drug discovery and biomarker development. In our recent work, we demonstrated a…”
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Adversarial Threshold Neural Computer for Molecular de Novo Design by Putin, Evgeny, Asadulaev, Arip, Vanhaelen, Quentin, Ivanenkov, Yan, Aladinskaya, Anastasia V, Aliper, Alex, Zhavoronkov, Alex

“…In this article, we propose the deep neural network Adversarial Threshold Neural Computer (ATNC). The ATNC model is intended for the de novo design of novel…”
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Quantum computing for near-term applications in generative chemistry and drug discovery by Pyrkov, Alexey, Aliper, Alex, Bezrukov, Dmitry, Lin, Yen-Chu, Polykovskiy, Daniil, Kamya, Petrina, Ren, Feng, Zhavoronkov, Alex

“…•Drug discovery is time consuming, expensive and experiences increasing challenges.•Generation of new drug candidates is one of the major challenges.•Quantum…”
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Prediction of Clinical Trials Outcomes Based on Target Choice and Clinical Trial Design with Multi‐Modal Artificial Intelligence by Aliper, Alex, Kudrin, Roman, Polykovskiy, Daniil, Kamya, Petrina, Tutubalina, Elena, Chen, Shan, Ren, Feng, Zhavoronkov, Alex

“…Drug discovery and development is a notoriously risky process with high failure rates at every stage, including disease modeling, target discovery, hit…”
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Chemistry42: An AI-Driven Platform for Molecular Design and Optimization by Ivanenkov, Yan A., Polykovskiy, Daniil, Bezrukov, Dmitry, Zagribelnyy, Bogdan, Aladinskiy, Vladimir, Kamya, Petrina, Aliper, Alex, Ren, Feng, Zhavoronkov, Alex

“…Chemistry42 is a software platform for de novo small molecule design and optimization that integrates Artificial Intelligence (AI) techniques with…”
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Discovery of 3-hydroxymethyl-azetidine derivatives as potent polymerase theta inhibitors by Wang, Yazhou, Wang, Chao, Liu, Jinxin, Sun, Deheng, Meng, Fanye, Zhang, Man, Aliper, Alex, Ren, Feng, Zhavoronkov, Alex, Ding, Xiao

“…[Display omitted] Inhibition of the low fidelity DNA polymerase Theta (Polθ) is emerging as an attractive, synthetic-lethal antitumor strategy in…”
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COSMIC: Molecular Conformation Space Modeling in Internal Coordinates with an Adversarial Framework by Kuznetsov, Maksim, Ryabov, Fedor, Schutski, Roman, Shayakhmetov, Rim, Lin, Yen-Chu, Aliper, Alex, Polykovskiy, Daniil

“…The fast and accurate conformation space modeling is an essential part of computational approaches for solving ligand and structure-based drug discovery…”
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Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer by Wang, Yazhou, Wang, Chao, Liu, Tingting, Qi, Hongyun, Chen, Shan, Cai, Xin, Zhang, Man, Aliper, Alex, Ren, Feng, Ding, Xiao, Zhavoronkov, Alex

“…Breast and gynecological cancers are among the leading causes of death in women worldwide, illustrating the urgent need for innovative treatment options. We…”
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Discovery of a Novel and Potent Cyclin-Dependent Kinase 8/19 (CDK8/19) Inhibitor for the Treatment of Cancer by Xu, Jianyu, Qi, Hongyun, Wang, Zhen, Wang, Ling, Steurer, Barbara, Cai, Xin, Liu, Jinxin, Aliper, Alex, Zhang, Man, Ren, Feng, Zhavoronkov, Alex, Ding, Xiao

“…The mediator kinases CDK8 and CDK19 control the dynamic transcription of selected genes in response to various signals and have been shown to be hijacked to…”
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Discovery of Bis-imidazolecarboxamide Derivatives as Novel, Potent, and Selective TNIK Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis by Aladinskiy, Vladimir, Kruse, Chris, Qin, Luoheng, Babin, Eugene, Fan, Yaya, Andreev, Georgiy, Zhao, Heng, Fu, Yanyun, Zhang, Man, Ivanenkov, Yan, Aliper, Alex, Zhavoronkov, Alex, Ren, Feng

“…Traf2- and Nck-interacting kinase (TNIK) has been identified as a promising therapeutic target for the treatment of fibrosis-driven diseases. Utilizing a…”
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TNIK’s emerging role in cancer, metabolism, and age-related diseases by Ewald, Collin Y., Pulous, Fadi E., Lok, Sarah Wing Yan, Pun, Frank W., Aliper, Alex, Ren, Feng, Zhavoronkov, Alex

“…Recent advances have demonstrated that Traf2- and Nck-interacting kinase (TNIK) is a key regulator of physiological and pathological metabolic signaling during…”
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Discovery of novel and selective SIK2 inhibitors by the application of AlphaFold structures and generative models by Zhu, Wei, Liu, Xiaosong, Li, Qi, Gao, Feng, Liu, Tingting, Chen, Xiaojing, Zhang, Man, Aliper, Alex, Ren, Feng, Ding, Xiao, Zhavoronkov, Alex

“…[Display omitted] Salt-inducible kinase 2 (SIK2) has been recognized as a potential target for anti-inflammation and anti-cancer therapy. In this paper, based…”
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Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia by Xu, Jianyu, Ding, Xiaoyu, Fu, Yanyun, Meng, Qingyuan, Wang, Ling, Zhang, Man, Xu, Chenxi, Chen, Shan, Aliper, Alex, Ren, Feng, Zhavoronkov, Alex, Ding, Xiao

“…Stabilization of hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase domain enzymes (PHDs) represents a breakthrough in treating anemia associated…”
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