Search Results - "Alink, G.M"

Genotoxic effects in the Eastern mudminnow (Umbra pygmaea) after prolonged exposure to River Rhine water, as assessed by use of the in vivo SCE and Comet assays by Penders, E.J.M., Spenkelink, A., Hoogenboezem, W., Rotteveel, S.G.P., Maas, J.L., Alink, G.M.

“…The production of drinking water from river water requires a certain minimal river water quality. The Association of River Rhine Water Works (RIWA), therefore,…”
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Genotoxic effects in the Eastern mudminnow ( Umbra pygmaea L.) after exposure to Rhine water, as assessed by use of the SCE and Comet assays: A comparison between 1978 and 2005 by Alink, G.M., Quik, J.T.K., Penders, E.J.M., Spenkelink, A., Rotteveel, S.G.P., Maas, J.L., Hoogenboezem, W.

“…Surface water used for drinking-water preparation requires continuous monitoring for the presence of toxic compounds. For monitoring of genotoxic compounds…”
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Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells by Moonen, H.J.J., Dommels, Y.E.M., van Zwam, M., van Herwijnen, M.H.M., Kleinjans, J.C.S., Alink, G.M., de Kok, T.M.C.M.

“…Dietary heterocyclic aromatic amines (HCA) and polyunsaturated fatty acids (PUFA) are both believed to play a role in colon carcinogenesis, and are both…”
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Cytotoxicity of surface-functionalized silicon and germanium nanoparticles: the dominant role of surface charges by Bhattacharjee, Sourav, Rietjens, Ivonne M C M, Singh, Mani P, Atkins, Tonya M, Purkait, Tapas K, Xu, Zejing, Regli, Sarah, Shukaliak, Amber, Clark, Rhett J, Mitchell, Brian S, Alink, Gerrit M, Marcelis, Antonius T M, Fink, Mark J, Veinot, Jonathan G C, Kauzlarich, Susan M, Zuilhof, Han

“…Although it is frequently hypothesized that surface (like surface charge) and physical characteristics (like particle size) play important roles in cellular…”
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Safety and nutritional assessment of GM plants and derived food and feed: The role of animal feeding trials by Haver, E., van, Alink, G.M, Cockburn, A, Kuiper, H.A, Peijnenburg, A.A.C.M

“…In this report the various elements of the safety and nutritional assessment procedure for genetically modified (GM) plant derived food and feed are discussed,…”
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Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells by Bhattacharjee, S, Haan, L.H.J. de, Evers, N.M, Jiang, X, Marcelis, A.T.M, Zuilhof, H, Rietjens, I.M.C.M, Alink, G.M

“…Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not…”
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Tissue distribution of quercetin in rats and pigs by de Boer, Vincent C J, Dihal, Ashwin A, van der Woude, Hester, Arts, Ilja C W, Wolffram, Siegfried, Alink, Gerrit M, Rietjens, Ivonne M C M, Keijer, Jaap, Hollman, Peter C H

“…Quercetin is a dietary polyphenolic compound with potentially beneficial effects on health. Claims that quercetin has biological effects are based mainly on in…”
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Differential effects of milk proteins, BSA and soy protein on 4NQO- or MNNG-induced SCEs in V79 cells by Bosselaers, I E, Caessens, P W, Van Boekel, M A, Alink, G M

“…The possible antimutagenic effects of five different proteins against the mutagen 4-nitroquinoline 1-oxide (4NQO) were assessed in a mammalian cell system,…”
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Antimutagenic effects of casein and its digestion products by van Boekel, M A, Weerens, C N, Holstra, A, Scheidtweiler, C E, Alink, G M

“…The antimutagenic potential of casein was investigated using several mutagens, including some food-related mutagens, and the Salmonella/microsome and…”
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Comparison of micro- and nanoscale Fe⁺³-containing (Hematite) particles for their toxicological properties in human lung cells in vitro by Bhattacharya, Kunal, Hoffmann, Eik, Schins, Roel F P, Boertz, Jens, Prantl, Eva-Maria, Alink, Gerrit M, Byrne, Hugh James, Kuhlbusch, Thomas A J, Rahman, Qamar, Wiggers, Hartmut, Schulz, Christof, Dopp, Elke

“…The specific properties of nanoscale particles, large surface-to-mass ratios and highly reactive surfaces, have increased their commercial application in many…”
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Antimutagenic activity of casein against MNNG in the E. coli DNA repair host-mediated assay by van Boekel, M.A.J.S., Goeptar, A.R., Alink, G.M.

“…The effect of caseinate and soy protein in the diet on the mutagenicity induced by N-methyl- N′-nitro- N-nitrosoguanidine (MNNG) was assessed in-vivo and…”
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Surface charge-specific cytotoxicity and cellular uptake of tri-block copolymer nanoparticles by Bhattacharjee, Sourav, Ershov, Dmitry, Gucht, Jasper van der, Alink, Gerrit M, Rietjens, Ivonne M. C. M, Zuilhof, Han, Marcelis, Antonius T. M.

“…Abstract A series of monodisperse (45 ± 5 nm) fluorescent nanoparticles from tri-block copolymers (polymeric nanoparticles (PNPs)) bearing different surface…”
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Synthesis and cytotoxicity of silicon nanoparticles with covalently attached organic monolayers by Ruizendaal, Loes, Bhattacharjee, Sourav, Pournazari, Kamyar, Rosso-Vasic, Milena, de Haan, Laura H. J., Alink, Gerrit M., Marcelis, Antonius T. M., Zuilhof, Han

“…Abstract A series of highly monodisperse silicon nanoparticles (Si NPs) with either positively (amine), neutral (azide) or negatively (carboxylic acid) charged…”
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In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling by PAINI, Alicia, PUNT, Ans, SCHOLZ, Gabriele, GREMAUD, Eric, SPENKELINK, Bert, ALINK, Gerrit, SCHILTER, Benoît, BLADEREN, Peter J. Van, RIETJENS, Ivonne M. C. M

“…Estragole is a naturally occurring food-borne genotoxic compound found in a variety of food sources, including spices and herbs. This results in human exposure…”
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Effect of heat processing and of vegetables and fruit in human diets on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats by Alink, G M, Kuiper, H A, Hollanders, V M, Koeman, J H

“…The purpose of the present study was to investigate the modulating effect of heat processing and of vegetables and fruit in human diets on…”
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Effects of outdoor and indoor airborne particulate matter on thyroid hormone and vitamin A metabolism by Alink, G M, Brouwer, A, Heussen, G A

“…Vitamin A is an important regulator of normal epithelial differentiation and proliferation and might act in the promotion phase of carcinogenesis. Vitamin A…”
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Surface charge-specific interactions between polymer nanoparticles and ABC transporters in Caco-2 cells by Bhattacharjee, Sourav, van Opstal, Edward J., Alink, Gerrit M., Marcelis, Antonius T. M., Zuilhof, Han, Rietjens, Ivonne M. C. M.

“…The surface charge-dependent transport of polymeric nanoparticles (PNPs) across Caco-2 monolayers grown on transwell culture systems as an in vitro model for…”
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Safety evaluation of neem ( Azadirachta indica) derived pesticides by Boeke, Sara J, Boersma, Marelle G, Alink, Gerrit M, van Loon, Joop J.A, van Huis, Arnold, Dicke, Marcel, Rietjens, Ivonne M.C.M

“…The neem tree, Azadirachta indica, provides many useful compounds that are used as pesticides and could be applied to protect stored seeds against insects…”
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Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats by Dihal, Ashwin A, de Boer, Vincent C J, van der Woude, Hester, Tilburgs, Chantal, Bruijntjes, Joost P, Alink, Gerrit M, Rietjens, Ivonne M C M, Woutersen, Ruud A, Stierum, Rob H

“…The effect of the flavonoid quercetin and its conjugate rutin was investigated on (biomarkers of) colorectal cancer (CRC). Male F344 rats (n = 42/group) were…”
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Carcinogenicity study of outdoor airborne particulate matter in newborn male NMRI mice by Heussen, G.A.H., van den Berg, J.HJ, der Meulen, H.C.Dreef-van, Alink, G.M.

“…An organic extract of airborne particulate matter (ARM) was tested for carcinogenicity at two dose levels in the newborn mouse bioassay. The samples used were…”
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