Adapted MMSE and TYM cognitive tests: how much powerful in screening for Alzheimer's disease in Iranian people

Adapted MMSE and TYM cognitive tests: how much powerful in screening for Alzheimer's disease in Iranian people

Alzheimer's disease (AD) is a major global health priority and providing an efficient way for early diagnosis of people developing dementia is important. The Mini-Mental State Examination (MMSE, total score = 30) and Test Your Memory (TYM, total score = 50) are widely used as screening tests fo...

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Bibliographic Details
Published in:Aging & mental health Vol. 24; no. 6; pp. 1010 - 1017
Main Authors: Salami, M., Alinaghipour, A., Daneshvar, R., Hamidi, G. A., Agahi, A., Soheili, M., Akbari, H., Esmaeili Taba, S. M.
Format: Journal Article
Language:English
Published: England Routledge 02-06-2020
Taylor & Francis Ltd
Subjects:
Age groups
Alzheimer's disease
Cognition
Cognitive ability
Cognitive functioning
Dementia
Dementia disorders
Disease
Global health
Medical diagnosis
Medical screening
Mini-Mental State Examination
MMSE
Neurodegenerative diseases
Public health
Sensitivity analysis
Test scores
Tests
TYM
TYM
dementia
Alzheimer’s disease
MMSE
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Summary:Alzheimer's disease (AD) is a major global health priority and providing an efficient way for early diagnosis of people developing dementia is important. The Mini-Mental State Examination (MMSE, total score = 30) and Test Your Memory (TYM, total score = 50) are widely used as screening tests for cognitive function. In the present study 174 subjects including healthy people (CON group) and those having Alzheimer's disease (AD group) were introduced to MMSE and TYM cognitive tests adjusted to Iranian population. Sensitivities and specificities with optimal cut-off scores, area under curve (AUC), positive predictive value (PPV) and negative predictive value (NPV) were measured for both tests. The MMSE scores of the CON and AD groups were 23.77 ± 0.327 and 10.88 ± 0.762, respectively. The TYM scores were 44.32 ± 0.389 and 14.37 ± 1.368 in the CON and AD participants, respectively. Findings in the MMSE test were: AUC = 0.962, optimal cut-off score = 18.5, sensitivity = 0.90 and specificity = 0.96. Values in the TYM test were: AUC = 0.991, optimal cut-off score = 31, sensitivity = 0.90 and specificity = 1. We found no correlation between the cognitive performance and age in the CON group but a positive correlation in the AD patients. On the other hand, t-test analysis indicated that achievement of the test scores are significantly sex dependent, with more scores attained by the females. Taken together, in regard to correct classification rate (CCR); the TYM test seems to be more appropriate for cognitive screening in our study. However, considering an analogous AUC, both tests are comparable and have high sensitivity and specificity for discriminating between people with and without AD.
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ISSN:1360-7863
1364-6915
DOI:10.1080/13607863.2019.1584786