Search Results - "Alifano, Marco"

Interconnection between Metabolism and Cell Cycle in Cancer by Icard, Philippe, Fournel, Ludovic, Wu, Zherui, Alifano, Marco, Lincet, Hubert

“…Cell cycle progression and division is regulated by checkpoint controls and sequential activation of cyclin-dependent kinases (CDKs). Understanding of how…”
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ATP citrate lyase: A central metabolic enzyme in cancer by Icard, Philippe, Wu, Zherui, Fournel, Ludovic, Coquerel, Antoine, Lincet, Hubert, Alifano, Marco

“…ACLY links energy metabolism provided by catabolic pathways to biosynthesis. ACLY, which has been found to be overexpressed in many cancers, converts citrate…”
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How the Warburg effect supports aggressiveness and drug resistance of cancer cells? by Icard, Philippe, Shulman, Seth, Farhat, Diana, Steyaert, Jean-Marc, Alifano, Marco, Lincet, Hubert

“…Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic metabolism. However, their proliferation is marked by a shift towards…”
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Cisplatin increases PD-L1 expression and optimizes immune check-point blockade in non-small cell lung cancer by Fournel, Ludovic, Wu, Zherui, Stadler, Nicolas, Damotte, Diane, Lococo, Filippo, Boulle, Geoffroy, Ségal-Bendirdjian, Evelyne, Bobbio, Antonio, Icard, Philippe, Trédaniel, Jean, Alifano, Marco, Forgez, Patricia

“…The number of clinical protocols testing combined therapies including immune check-point inhibitors and platinum salts is currently increasing in lung cancer…”
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TP53, STK11 , and EGFR Mutations Predict Tumor Immune Profile and the Response to Anti-PD-1 in Lung Adenocarcinoma by Biton, Jérôme, Mansuet-Lupo, Audrey, Pécuchet, Nicolas, Alifano, Marco, Ouakrim, Hanane, Arrondeau, Jennifer, Boudou-Rouquette, Pascaline, Goldwasser, François, Leroy, Karen, Goc, Jeremy, Wislez, Marie, Germain, Claire, Laurent-Puig, Pierre, Dieu-Nosjean, Marie-Caroline, Cremer, Isabelle, Herbst, Ronald, Blons, Hélène, Damotte, Diane

“…By unlocking antitumor immunity, antibodies targeting programmed cell death 1 (PD-1) exhibit impressive clinical results in non-small cell lung cancer,…”
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Behavioral Food Addiction During Lockdown: Time for Awareness, Time to Prepare the Aftermath by Cherikh, Faredj, Frey, Sébastien, Bel, Corali, Attanasi, Giuseppe, Alifano, Marco, Iannelli, Antonio

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Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer by Giraldo, Nicolas A, Becht, Etienne, Pagès, Franck, Skliris, Georgios, Verkarre, Virginie, Vano, Yann, Mejean, Arnaud, Saint-Aubert, Nicolas, Lacroix, Laetitia, Natario, Ivo, Lupo, Audrey, Alifano, Marco, Damotte, Diane, Cazes, Aurelie, Triebel, Frederic, Freeman, Gordon J, Dieu-Nosjean, Marie-Caroline, Oudard, Stephane, Fridman, Wolf H, Sautès-Fridman, Catherine

“…Clear cell renal cell carcinoma (ccRCC) has shown durable responses to checkpoint blockade therapies. However, important gaps persist in the understanding of…”
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Obesity and COVID-19: ACE 2, the Missing Tile by Iannelli, Antonio, Favre, Guillaume, Frey, Sébastien, Esnault, Vincent, Gugenheim, Jean, Bouam, Samir, Schiavo, Luigi, Tran, Albert, Alifano, Marco

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Gut Microbiota Host-Gene Interaction by Cuomo, Paola, Capparelli, Rosanna, Alifano, Marco, Iannelli, Antonio, Iannelli, Domenico

“…Studies carried out in the last ten years have shown that the metabolites made up from the gut microbiota are essential for multiple functions, such as the…”
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Body Mass Index and Total Psoas Area Affect Outcomes In Patients Undergoing Pneumonectomy for Cancer by Hervochon, Remi, MD, Bobbio, Antonio, MD, PhD, Guinet, Claude, MD, PhD, Mansuet-Lupo, Audrey, MD, PhD, Rabbat, Antoine, MD, Régnard, Jean-François, MD, Roche, Nicolas, MD, PhD, Damotte, Diane, MD, PhD, Iannelli, Antonio, MD, PhD, Alifano, Marco, MD, PhD

“…Background Hypothesizing that morphometric measurements are reliable markers of fitness in patients with lung cancer requiring aggressive surgical…”
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The Impact of Previous History of Bariatric Surgery on Outcome of COVID-19. A Nationwide Medico-Administrative French Study by Iannelli, Antonio, Bouam, Samir, Schneck, Anne-Sophie, Frey, Sébastien, Zarca, Kevin, Gugenheim, Jean, Alifano, Marco

“…Purpose To determine the risk of invasive mechanical ventilation and death in obese individuals with a history of bariatric surgery (BS) admitted for COVID-19…”
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Esophageal Cancer in Patients Undergoing Bariatric Surgery: What Is the Real Burden? by Iannelli, Antonio, Bouam, Samir, Schneck, Anne-Sophie, Alifano, Marco

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The tumor inflammation signature (TIS) is associated with anti-PD-1 treatment benefit in the CERTIM pan-cancer cohort by Damotte, Diane, Warren, Sarah, Arrondeau, Jennifer, Boudou-Rouquette, Pascaline, Mansuet-Lupo, Audrey, Biton, Jérôme, Ouakrim, Hanane, Alifano, Marco, Gervais, Claire, Bellesoeur, Audrey, Kramkimel, Nora, Tlemsani, Camille, Burroni, Barbara, Duche, Angéline, Letourneur, Franck, Si, Han, Halpin, Rebecca, Creasy, Todd, Herbst, Ronald, Ren, Xing, Morel, Pascale, Cesano, Alessandra, Goldwasser, François, Leroy, Karen

“…The 18-gene tumor inflammation signature (TIS) is a clinical research assay that enriches for clinical benefit to immune checkpoint blockade. We evaluated its…”
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Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma by PLATONOVA, Sophia, CHERFILS-VICINI, Julien, FRIDMAN, Wolf-Herman, SAUTES-FRIDMAN, Catherine, CREMER, Isabelle, DAMOTTE, Diane, CROZET, Lucile, VIEILLARD, Vincent, VALIDIRE, Pierre, ANDRE, Pascale, DIEU-NOSJEAN, Marie-Caroline, ALIFANO, Marco, REGNARD, Jean-François

“…Both the innate and adaptive immune systems contribute to tumor immunosurveillance in mice and humans; however, there is a paucity of direct evidence of a role…”
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Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin by REMARK, Romain, ALIFANO, Marco, FLEJOU, Jean-François, GIBAULT, Laure, VERKARRE, Virginie, REGNARD, Jean-François, PAGES, Olivier-Nicolas, OUDARD, Stéphane, MLECNIK, Bernhard, SAUTES-FRIDMAN, Catherine, FRIDMAN, Wolf-Herman, DAMOTTE, Diane, CREMER, Isabelle, LUPO, Audrey, DIEU-NOSJEAN, Marie-Caroline, RIQUET, Marc, CROZET, Lucile, OUAKRIM, Hanane, GOC, Jeremy, CAZES, Aurélie

“…If immune cells are involved in tumor surveillance and have a prognostic impact in most primary tumors, little is known about their significance in metastases…”
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Clinical and molecular characteristics associated with high PD-L1 expression in EGFR-mutated lung adenocarcinoma by Slomka, Jeremy, Berthou, Hugo, Mansuet-Lupo, Audrey, Blons, Hélène, Fabre, Elizabeth, Lerner, Ivan, Rance, Bastien, Alifano, Marco, Chapron, Jeanne, Birsen, Gary, Gibault, Laure, Arrondeau, Jennifer, Leroy, Karen, Wislez, Marie

“…Objective Recent evidence suggests that elevated levels of PD-L1 expression may be linked to early resistance to TKI and reduced survival in NSCLC with EGFR…”
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Bacteria-driven peribronchial lymphoid neogenesis in bronchiectasis and cystic fibrosis by Frija-Masson, Justine, Martin, Clémence, Regard, Lucile, Lothe, Marie-Noëlle, Touqui, Lhousseine, Durand, Aurélie, Lucas, Bruno, Damotte, Diane, Alifano, Marco, Fajac, Isabelle, Burgel, Pierre-Régis

“…We aimed to characterise lymphoid neogenesis in bronchiectasis and cystic fibrosis (CF) lungs and to examine the role of bacterial infection.Lymphoid…”
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Systemic inflammation, nutritional status and tumor immune microenvironment determine outcome of resected non-small cell lung cancer by Alifano, Marco, Mansuet-Lupo, Audrey, Lococo, Filippo, Roche, Nicolas, Bobbio, Antonio, Canny, Emelyne, Schussler, Olivier, Dermine, Hervé, Régnard, Jean-François, Burroni, Barbara, Goc, Jérémy, Biton, Jérôme, Ouakrim, Hanane, Cremer, Isabelle, Dieu-Nosjean, Marie-Caroline, Damotte, Diane

“…Hypothesizing that nutritional status, systemic inflammation and tumoral immune microenvironment play a role as determinants of lung cancer evolution, the…”
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Mitochondrial metabolism sustains CD8+ T cell migration for an efficient infiltration into solid tumors by Simula, Luca, Fumagalli, Mattia, Vimeux, Lene, Rajnpreht, Irena, Icard, Philippe, Birsen, Gary, An, Dongjie, Pendino, Frédéric, Rouault, Adrien, Bercovici, Nadège, Damotte, Diane, Lupo-Mansuet, Audrey, Alifano, Marco, Alves-Guerra, Marie-Clotilde, Donnadieu, Emmanuel

“…The ability of CD8 + T cells to infiltrate solid tumors and reach cancer cells is associated with improved patient survival and responses to immunotherapy…”
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Predictive Value of Soluble PD-1, PD-L1, VEGFA, CD40 Ligand and CD44 for Nivolumab Therapy in Advanced Non-Small Cell Lung Cancer: A Case-Control Study by Tiako Meyo, Manuela, Jouinot, Anne, Giroux-Leprieur, Etienne, Fabre, Elizabeth, Wislez, Marie, Alifano, Marco, Leroy, Karen, Boudou-Rouquette, Pascaline, Tlemsani, Camille, Khoudour, Nihel, Arrondeau, Jennifer, Thomas-Schoemann, Audrey, Blons, Hélène, Mansuet-Lupo, Audrey, Damotte, Diane, Vidal, Michel, Goldwasser, François, Alexandre, Jérôme, Blanchet, Benoit

“…A large interindividual variability has been observed in anti Programmed cell Death 1 (anti-PD1) therapies efficacy. The aim of this study is to assess the…”
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