Search Results - "Aliev, K T"

Optimization of recombinant antibody production based on the vector design and the level of metabolites for generation of Ig- producing stable cell lines by Toporova, V. A, Argentova, V. V, Aliev, T. K, Panina, A. A, Dolgikh, D. A, Kirpichnikov, M. P

“…Background The biopharmaceutical industry is significantly growing worldwide, and the Chinese hamster ovary (CHO) cells are used as a main expression host for…”
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Properties of hexahistidine-tagged organophosphate hydrolase by Votchitseva, Yu A, Efremenko, E N, Aliev, T K, Varfolomeyev, S D

“…The catalytic properties of organophosphate hydrolase (OPH) containing a hexahistidine tag His6 (His6-OPH) and purified to 98% homogeneity were investigated…”
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Recombinant monoclonal antibodies for rabies post-exposure prophylaxis by Ilina, E. N., Larina, M. V., Aliev, T. K., Dolgikh, D. A., Kirpichnikov, M. P.

“…Rabies virus is a prototypical neurotropic virus that causes one of the most dangerous zoonotic diseases in humans. Humanized or fully human monoclonal…”
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Targeting Extracellular Vesicles to Dendritic Cells and Macrophages by Ovchinnikova, Leyla A., Filimonova, Ioanna N., Zakharova, Maria Y., Balabashin, Dmitriy S., Aliev, Teimour K., Lomakin, Yakov A., Gabibov, Alexander G.

“…Targeting protein therapeutics to specific cells and tissues is a major challenge in modern medicine. Improving the specificity of protein therapeutic delivery…”
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Development of a Humanized Antibody 5D3Hu against the PRAME Tumor Antigen by Larina, M. V., Finashutina, Y. P., Lyzhko, N. A., Misyurin, V. A., Novoseletsky, V. N., Dolgikh, D. A., Solopova, O. N., Moysenovich, A. M., Balabashin, D. S., Aliev, T. K., Misyurin, A. V., Kirpichnikov, M. P.

“…The PRAME antigen, which is a significant target for monoclonal antibodies, is a tumor-specific marker that is active at all stages of tumor cell…”
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Development of a Serum-Free Media Based on the Optimal Combination of Recombinant Protein Additives and Hydrolysates of Non-animal Origin to Produce Immunoglobulins by Balabashin, D. S., Kaliberda, E. N., Smirnov, I. V., Mokrushina, Y. A., Bobik, T. V., Aliev, T. K., Dolgikh, D. A., Kirpichnikov, M. P.

“…The potential ability to cultivate a recombinant immunoglobulin (IgG1)-producer line in Iscove’s Modified Dulbecco Medium (IMDM) as the base cultivation medium…”
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Analysis of the Specificity of Auto-Reactive Antibodies to Individual Fragments of the Extracellular Domain of Desmoglein 3 in Patients with Pemphigus Vulgaris by Kubanov, A. A., Deryabin, D. G., Shpilevaya, M. V., Karamova, A. E., Nikonorov, A. A., Larina, E. N., Aliev, T. K., Dolgikh, D. A., Bobik, T. V., Smirnov, I. V., Gabibov, A. G., Kirpichnikov, M. P.

“…A method for the analysis of the epitope specificity of auto-reactive antibodies to desmoglein 3 (Dsg3) using competitive ELISA has been developed. It is based…”
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Epitope Analysis of Murine and Chimeric Monoclonal Antibodies Recognizing the Cancer Testis Antigen PRAME by Misyurin, V. A., Finashutina, Yu. P., Turba, A. A., Larina, M. V., Solopova, O. N., Lyzhko, N. A., Kesaeva, L. A., Kasatkina, N. N., Aliev, T. K., Misyurin, A. V., Kirpichnikov, M. P.

“…We investigated the epitope specificity of different monoclonal antibodies recognizing the cancer testis antigen PRAME. Antibody 5D3 binds to the fragment of…”
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Development of the Bispecific Antibody in Fab-scFv Format Based on an Antibody to Human Interferon Beta-1 and Antibody to HER2 Receptor by Panina, A. A., Toporova, V. A., Rybchenko, V. S., Balabashin, D. S., Argentova, V. V., Yakimov, S. A., Solopova, O. N., Aliev, T. K., Dolgikh, D. A., Sveshnikov, P. G., Kirpichnikov, M. P.

“…— The development of new therapies for malignant tumors is an urgent task. Currently, the humanized antibody trastuzumab is considered the “gold standard” in…”
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Generation and Characterization of Human Interferon-beta Neutralizing Humanized Antibody by Rybchenko, V. S., Panina, A. A., Novoseletsky, N. V., Balabashin, D. S., Yakimov, S. A., Solopova, O. N., Sveshnikov, P. G., Aliev, T. K., Dolgikh, D. A., Kirpichnikov, M. P.

“…Humanization of antibodies for the development of novel therapeutic agents with low immunogenicity remains a topical problem in modern science. In the present…”
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Monoclonal Antibodies to PRAME Protein Slow the Development of PRAME-Expressing Tumor by Solopova, O. N., Finashutina, Yu. P., Kasatkina, N. N., Lyzhko, N. A., Turba, A. A., Kesaeva, L. A., Misyurin, V. A., Misyurin, A. V., Larina, M. V., Aliev, T. K., Kirpichnikov, M. P.

“…Two monoclonal antibodies recognizing non-overlapping epitopes of the PRAME protein were injected into immunocompetent mice to study their influence on the…”
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B Cell Profiling in Patients with Pemphigus Vulgaris by Abrikosova, V A, Mokrushina, Y A, Ovchinnikova, L A, Larina, E N, Terekhov, S S, Baranova, M N, Lomakin, Y A, Balabashin, D S, Bobik, T V, Kaliberda, E N, Knorre, V D, Shpilevaya, M V, Aliev, T K, Deryabin, D G, Karamova, A E, Kubanov, A A, Kirpichnikov, M P, Smirnov, I V

“…Pemphigus vulgaris is a severe, socially significant autoimmune disease associated with autoantibodies to the desmoglein 3 antigen. The disease affects all age…”
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Production of the Extracellular Part of the ErbB2 Receptor for the Study of Immunobiologicals by Rybchenko, V. S., Balabashin, D. S., Panina, A. A., Solopova, O. N., Yakimov, S. A., Aliev, T. K., Dolgikh, D. A., Kirpichnikov, M. P.

“…— The extracellular part of the ErbB2 receptor (ecdErbB2), an oncological marker and a target for therapeutic antibodies, has been expressed in eukaryotic CHO…”
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Recombinant Bispecific Antibodies to the Human ErbB2 Receptor and Interferon-Beta by Panina, A A, Rybchenko, V S, Solopova, O N, Balabashin, D S, Yakimov, S A, Aliev, T K, Dolgikh, D A, Sveshnikov, P G, Kirpichnikov, M P

“…The development of and research into new therapies that can selectively and effectively destroy tumor cells that overexpress the ErbB2 receptor is a pressing…”
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Production of Recombinant Human Transferrin in Eukaryotic Pichia pastoris Expression System by Bobik, T. V., Popov, R. Yu, Aliev, T. K., Mokrushina, Yu. A., Shamborant, O. G., Khurs, E. N., Knorre, V. D., Smirnov, I. V., Gabibov, A. G.

“…The development and manufacturing of serum-free culture media allowing reducing the costs of preparations and standardizing the biotechnological process are…”
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Recombinant Fragment of the Extracellular Domain of Human Desmoglein 3 Fused with the Fc-Fragment of Human IgG1 Selectively Adsorbs Autoreactive Antibodies from the Sera of Pemphigus Patients by Larina, E. N., Karasev, V. S., Shpilevaya, M. V., Aliev, T. K., Bochkova, O. P., Karamova, A. E., Balabashin, D. S., Deryabin, D. G., Bobik, T. V., Smirnov, I. V., Kubanov, A. A., Staroverov, S. M., Gabibov, A. G., Kirpichnikov, M. P.

“…Using the recombinant second fragment of the extracellular domain (EC2) of human desmoglein type 3 (Dsg3) as an affinity ligand, an immunosorbent was obtained…”
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Development and characterization of antibodies against aflatoxins by Kalinichenko, A. A, Toporova, V. A, Panina, A. A, Aliev, T. K, Kryukova, E. A, Shemchukova, O. B, Solopova, O. N, Pozdnyakova, L. P, Sveshnikov, P. G, Dolgikh, D. A, Kirpichnikov, M. P

“…A panel of ten monoclonal antibodies against aflatoxins B1, B2, and G2 was produced and comprehensively characterized. The affinity and cross reactivity of…”
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Biomarkers for Cerebral Ischemia as a Novel Method for Validating the Efficacy of Neurocytoprotectors by Dambinova, S. A., Aliev, K. T., Bondarenko, E. V., Ponomarev, G. V., Skoromets, A. A., Skoromets, A. P., Skoromets, T. A., Smolko, D. G., Shumilina, M. V.

“…Objectives. To assess the diagnostic value of NR2 peptide as a biomarker for cerebral ischemia by studying its plasma concentration in patients with ischemic…”
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Postgenomic chemistry: New problems and challenges by Varfolomeyev, S. D., Aliev, T. K., Efremenko, E. N.

“…New trends in chemistry induced by genetic engineering and genomic information are analyzed. Genomic information and bioinformatics make the identification of…”
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The Generation of the Human mAb RabD4 Specific to the Rabies Virus Glycoprotein and Characterization Thereof by Ilina, E. N., Solopova, E. V., Aliev, T. K., Larina, M. V., Balabashin, D. S., Varlamov, N. E., Dolgikh, D. A., Sveshnikov, P. G., Kirpichnikov, M. P.

“…We generated a novel human neutralizing human mAb RabD4 against rabies virus glycoprotein using in vitro stimulation of human peripheral B cells produced by…”
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