Search Results - "Alice J. A. M. Sijts"

Characterization of polarization states of canine monocyte derived macrophages by Lyu, Qingkang, Veldhuizen, Edwin J. A, Ludwig, Irene S, Rutten, Victor P. M. G, van Eden, Willem, Sijts, Alice J. A. M, Broere, Femke

“…Macrophages can reversibly polarize into multiple functional subsets depending on their micro-environment. Identification and understanding the functionality…”
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Shortened Hinge Design of Fab x sdAb-Fc Bispecific Antibodies Enhances Redirected T-Cell Killing of Tumor Cells by Huang, Shuyu, Segués, Aina, Waterfall, Martin, Wright, David, Vayssiere, Charlotte, van Duijnhoven, Sander M J, van Elsas, Andrea, Sijts, Alice J A M, Zaiss, Dietmar M

“…T cell engager (TCE) antibodies have emerged as promising cancer therapeutics that link cytotoxic T-cells to tumor cells by simultaneously binding to CD3E on…”
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Hsp70 and NF-kB Mediated Control of Innate Inflammatory Responses in a Canine Macrophage Cell Line by Lyu, Qingkang, Wawrzyniuk, Magdalena, Rutten, Victor P M G, van Eden, Willem, Sijts, Alice J A M, Broere, Femke

“…The pathogenesis of many inflammatory diseases is associated with the uncontrolled activation of nuclear factor kappa B (NF-κB) in macrophages. Previous…”
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Proteasome Immunosubunit Multicatalytic Endopeptidase Complex-Like 1 Is a T-Cell-Intrinsic Factor Influencing Homeostatic Expansion by Zaiss, Dietmar M.W, de Graaf, Natascha, Sijts, Alice J.A.M

“…Homeostatic regulatory mechanisms maintain the constant ratios between different lymphocyte subsets in the secondary lymphoid organs. How this dynamic…”
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CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice by van Helden, Mary J G, Zaiss, Dietmar M W, Sijts, Alice J A M

“…Natural killer (NK) cells are innate lymphocytes that play an important role in control of viral infections. We recently showed that intranasal infection of…”
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The Function of Immunoproteasomes-An Immunologists' Perspective by van den Eshof, Bart L, Medfai, Lobna, Nolfi, Emanuele, Wawrzyniuk, Magdalena, Sijts, Alice J A M

“…Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a…”
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Enumeration of Cytotoxic CD8 T Cells Ex Vivo during the Response to Listeria monocytogenes Infection by Zaiss, Dietmar M.W, Sijts, Alice J.A.M, Mosmann, Tim R

“…Cytotoxicity is a key effector function of CD8 T cells. However, what proportion of antigen-specific CD8 T cells in vivo exert cytotoxic activity during a…”
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Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy by Huang, Shuyu, van Duijnhoven, Sander M. J., Sijts, Alice J. A. M., van Elsas, Andrea

“…Purpose Bispecific antibodies (BsAbs) have emerged as a leading drug class for cancer therapy and are becoming increasingly of interest for therapeutic…”
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Identification of novel avian influenza virus derived CD8+ T-cell epitopes by Reemers, Sylvia S N, van Haarlem, Daphne A, Sijts, Alice J A M, Vervelde, Lonneke, Jansen, Christine A

“…Avian influenza virus (AIV) infection is a continuing threat to both humans and poultry. Influenza virus specific CD8+ T cells are associated with protection…”
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Rates of Processing Determine the Immunogenicity of Immunoproteasome-Generated Epitopes by Deol, Parampal, Zaiss, Dietmar M. W, Monaco, John J, Sijts, Alice J. A. M

“…CD8 T cells resolve intracellular pathogens by responding to pathogen-derived peptides that are presented on the cell surface by MHC class I molecules…”
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Intranasal delivery of Salmonella OMVs decorated with Chlamydia trachomatis antigens induces specific local and systemic immune responses by Huynh, Dung T, Nolfi, Emanuele, Medfai, Lobna, van Ulsen, Peter, Jong, Wouter S P, Sijts, Alice J A M, Luirink, Joen

“…is an obligate intracellular pathogen responsible for the most prevalent bacterial sexually transmitted disease globally. The high prevalence of chlamydial…”
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PI31 Is a Modulator of Proteasome Formation and Antigen Processing by Dietmar M. W. Zaiss, Standera, Sybille, Peter-M. Kloetzel, Alice J. A. M. Sijts

“…Regulation of the proteasome system, which is responsible for the generation of most MHC class I-bound peptides, occurs through the interaction of the 20S…”
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Immunoproteasome-deficiency has no effects on NK cell education, but confers lymphocytes into targets for NK cells in infected wild-type mice by van Helden, Mary J G, de Graaf, Natascha, Bekker, Cornelis P J, Boog, Claire J P, Zaiss, Dietmar M W, Sijts, Alice J A M

“…Natural killer (NK) cells are part of the innate immune system and contribute to the eradication of virus infected cells and tumors. NK cells express…”
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Leucinostatin acts as a co-inducer for heat shock protein 70 in cultured canine retinal pigment epithelial cells by Lyu, Qingkang, Ludwig, Irene S., Kooten, Peter J. S., Sijts, Alice J. A. M., Rutten, Victor P. M. G., van Eden, Willem, Broere, Femke

“…Dysregulation of retinal pigment epithelium (RPE) cells is the main cause of a variety of ocular diseases. Potentially heat shock proteins, by preventing…”
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Nanoporous Microneedle Arrays Effectively Induce Antibody Responses against Diphtheria and Tetanus Toxoid by de Groot, Anne Marit, Platteel, Anouk C M, Kuijt, Nico, van Kooten, Peter J S, Vos, Pieter Jan, Sijts, Alice J A M, van der Maaden, Koen

“…The skin is immunologically very potent because of the high number of antigen-presenting cells in the dermis and epidermis, and is therefore considered to be…”
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An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development? by Platteel, Anouk C M, Liepe, Juliane, van Eden, Willem, Mishto, Michele, Sijts, Alice J A M

“…Efficient and safe induction of CD8 T cell responses is a desired characteristic of vaccines against intracellular pathogens. To achieve this, a new generation…”
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The bone marrow functions as the central site of proliferation for long-lived NK cells by van Helden, Mary J G, de Graaf, Natascha, Boog, Claire J P, Topham, David J, Zaiss, Dietmar M W, Sijts, Alice J A M

“…NK cells play an important role in the early defense against invading pathogens. Although it is well established that infection leads to a substantial, local…”
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PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I‐binding peptides in vivo by de Graaf, Natascha, van Helden, Mary J. G., Textoris‐Taube, Kathrin, Chiba, Tomoki, Topham, David J., Kloetzel, Peter‐Michael, Zaiss, Dietmar M. W., Sijts, Alice J. A. M.

“…Proteasomes play a fundamental role in the processing of intracellular antigens into peptides that bind to MHC class I molecules for the presentation of CD8+ T…”
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Efficacy Testing of H56 cDNA Tattoo Immunization against Tuberculosis in a Mouse Model by Platteel, Anouk C M, Nieuwenhuizen, Natalie E, Domaszewska, Teresa, Schürer, Stefanie, Zedler, Ulrike, Brinkmann, Volker, Sijts, Alice J A M, Kaufmann, Stefan H E

“…Tuberculosis (TB), caused by ( ), remains a global threat. The only approved vaccine against TB, bacillus Calmette-Guérin (BCG), provides insufficient…”
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Induction of humoral and cellular immune responses by antigen-expressing immunostimulatory liposomes by Amidi, Maryam, van Helden, Mary J.G., Tabataei, Neda Rafiei, de Goede, Anna L., Schouten, Marijn, de Bot, Volkert, Lanzi, Anastasia, Gruters, Rob A., Rimmelzwaan, Guus F., Sijts, Alice J.A.M., Mastrobattista, Enrico

“…Recently we have shown that liposomes can be used as artificial microbes for the production and delivery of DNA-encoded antigens. These so-called…”
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