Search Results - "Aliazis, Konstantinos"

Immune-related adverse effects of checkpoint immunotherapy and implications for the treatment of patients with cancer and autoimmune diseases by Ibis, Betul, Aliazis, Konstantinos, Cao, Carol, Yenyuwadee, Sasitorn, Boussiotis, Vassiliki A

“…During the past decade, there has been a revolution in cancer therapeutics by the emergence of antibody-based immunotherapies that modulate immune responses…”
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The Putative Roles and Functions of Indel, Repetition and Duplication Events in Alphavirus Non-Structural Protein 3 Hypervariable Domain (nsP3 HVD) in Evolution, Viability and Re-Emergence by Abdullah, Nurshariza, Ahemad, Nafees, Aliazis, Konstantinos, Khairat, Jasmine Elanie, Lee, Thong Chuan, Abdul Ahmad, Siti Aisyah, Adnan, Nur Amelia Azreen, Macha, Nur Omar, Hassan, Sharifah Syed

“…Alphavirus non-structural proteins 1–4 (nsP1, nsP2, nsP3, and nsP4) are known to be crucial for alphavirus RNA replication and translation. To date, nsP3 has…”
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Emergency myelopoiesis in solid cancers by Aliazis, Konstantinos, Yenyuwadee, Sasitorn, Phikulsod, Ployploen, Boussiotis, Vassiliki A.

“…Summary Cells of the innate and adaptive immune systems are the progeny of haematopoietic stem and progenitor cells (HSPCs). During steady‐state myelopoiesis,…”
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Pparβ/δ Has an Indispensable Role in T Cell Function and Anti-Tumor Responses by Ibis, Betul, Christofides, Anthos, Aliazis, Konstantinos, Shah, Rushil, Pal, Rinku, Boussiotis, Vassiliki A

“…The peroxisome proliferator-activated receptors (PPARs) are a group of transcriptional factor of the nuclear hormone receptor superfamily, which promote…”
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PD-1 Expression By Dendritic Cells Is a Key Regulator of T-Cell Immunity in Cancer by Shah, Rushil, Aliazis, Konstantinos, Christofides, Anthos, Pham, Angelique A, Pal, Rinku, Boussiotis, Vassiliki A

“…Programmed cell death 1 (PD-1) is an inhibitory receptor expressed on a variety of immune cells and a therapeutic target of checkpoint immunotherapy for cancer…”
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Specific PD-1 Deletion on Regulatory T Cells Leads to Enhanced Anti-Tumor Responses by Aliazis, Konstantinos, Christofides, Anthos, Aksoylar, Halil-Ibrahim, Shah, Rushil, Pal, Rinku, Patsoukis, Nikolaos, Boussiotis, Vassiliki A

“…Programmed cell death 1 (PD-1) is a T cell inhibitory receptor and the most extensively exploited therapeutic target of checkpoint immunotherapy in cancer…”
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Immune cellular components and signaling pathways in the tumor microenvironment by Yenyuwadee, Sasitorn, Aliazis, Konstantinos, Wang, Qi, Christofides, Anthos, Shah, Rushil, Patsoukis, Nikolaos, Boussiotis, Vassiliki A.

“…During the past decade there has been a revolution in cancer therapeutics by the emergence of antibody-based and cell-based immunotherapies that modulate…”
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42243 RIAM regulates T cell migration and activation in melanoma by Yenyuwadee, Sasitorn, Aliazis, Konstantinos, Christofides, Anthos, Aksoylar, Halil-Ibrahim, Pal, Rinku, Boussiotis, Vassiliki A.

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SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses by Christofides, Anthos, Katopodi, Xanthi-Lida, Cao, Carol, Karagkouni, Dimitra, Aliazis, Konstantinos, Yenyuwadee, Sasitorn, Aksoylar, Halil-Ibrahim, Pal, Rinku, Mahmoud, Mohamed A. A., Strauss, Laura, Tijaro-Ovalle, Natalia M., Boon, Louis, Asara, John, Vlachos, Ioannis S., Patsoukis, Nikolaos, Boussiotis, Vassiliki A.

“…The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-2. However, mice with a T-cell-specific deletion of SHP-2 do not…”
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A four-cell pathway orchestrated by Flt3-L-dependent cDCs controls anti-tumor responses by Aliazis, Konstantinos, Boussiotis, Vassiliki A

“…A study by Régnier et al. shows that Flt3-ligand (FL) levels program two distinct mechanisms of anti-tumor immunity. Low FL levels allow recruitment of T…”
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SHP-2 Regulates Myeloid Cell Differentiation, Anti-Tumor Responses and Innate Immune Memory by Christofides, Anthos, Katopodi, Xanthi-Leda, Cao, Carol, Karagkouni, Dimitra, Aliazis, Konstantinos, Yenyuwadee, Sasitorn, Pal, Rinku, Asara, John, Vlachos, Ioannis, Patsoukis, Nikolaos, Boussiotis, Vassiliki A

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The human liver microenvironment shapes the homing and function of CD4 + T-cell populations by Wiggins, Benjamin G, Pallett, Laura J, Li, Xiaoyan, Davies, Scott P, Amin, Oliver E, Gill, Upkar S, Kucykowicz, Stephanie, Patel, Arzoo M, Aliazis, Konstantinos, Liu, Yuxin S, Reynolds, Gary M, Davidson, Brian R, Gander, Amir, Luong, Tu Vinh, Hirschfield, Gideon M, Kennedy, Patrick T F, Huang, Yuehua, Maini, Mala K, Stamataki, Zania

“…Tissue-resident memory T cells (T ) are vital immune sentinels that provide protective immunity. While hepatic CD8 T have been well described, little is known…”
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The effect of pharmacological cessation and restoration of menstrual cycle on bone metabolism in premenopausal women with endometriosis by Anastasilakis, Athanasios D., Papachatzopoulos, Stergios, Makras, Polyzois, Gkiomisi, Athina, Nikolakopoulos, Panagiotis, Polyzos, Stergios A., Ntenti, Charikleia, Ballaouri, Iris, Gerou, Spyridon, Tsachouridou, Olga, Papatheodorou, Athanasios, Aliazis, Konstantinos, Fermanoglou, Sofia, Bisbinas, Ilias, Yavropoulou, Maria P.

“…GnRH-analogs induce bone loss. We aimed to investigate the effects of goserelin-induced menstrual cessation (MC) and subsequent menstrual restoration (MR) on…”
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Driver Mutations Dictate the Immunologic Landscape and Response to Checkpoint Immunotherapy of Glioblastoma by Yeo, Alan T, Shah, Rushil, Aliazis, Konstantinos, Pal, Rinku, Xu, Tuoye, Zhang, Piyan, Rawal, Shruti, Rose, Christopher M, Varn, Frederick S, Appleman, Vicky A, Yoon, Joon, Varma, Hemant, Gygi, Steven P, Verhaak, Roel G W, Boussiotis, Vassiliki A, Charest, Al

“…The composition of the tumor immune microenvironment (TIME) is considered a key determinant of patients' response to immunotherapy. The mechanisms underlying…”
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In Vitro and Ex Vivo Models to Study T Cell Migration Through the Human Liver Parenchyma by Wiggins, Benjamin G, Aliazis, Konstantinos, Davies, Scott P, Hirschfield, Gideon, Lalor, Patricia F, Reynolds, Gary, Stamataki, Zania

“…The liver is the largest internal organ and filters around 3 pints of blood per minute. This continuous flux of blood should not be confused with rapid egress…”
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