Search Results - "Ali Salahpour"

Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease by Lohr, Kelly M., Masoud, Shababa T., Salahpour, Ali, Miller, Gary W., Bolam, Paul

“…Dopamine was first identified as a neurotransmitter localized to the midbrain over 50 years ago. The dopamine transporter (DAT; SLC6A3) and the vesicular…”
Get full text

Consequences of NMDA receptor deficiency can be rescued in the adult brain by Mielnik, Catharine A., Binko, Mary A., Chen, Yuxiao, Funk, Adam J., Johansson, Emily M., Intson, Katheron, Sivananthan, Nirun, Islam, Rehnuma, Milenkovic, Marija, Horsfall, Wendy, Ross, Ruth A., Groc, Laurent, Salahpour, Ali, McCullumsmith, Robert E., Tripathy, Shreejoy, Lambe, Evelyn K., Ramsey, Amy J.

“…N-methyl-D-aspartate receptors (NMDARs) are required to shape activity-dependent connections in the developing and adult brain. Impaired NMDAR signalling…”
Get full text

Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo by Lohr, Kelly M., Bernstein, Alison I., Stout, Kristen A., Dunn, Amy R., Lazo, Carlos R., Alter, Shawn P., Wang, Minzheng, Li, Yingjie, Fan, Xueliang, Hess, Ellen J., Yi, Hong, Vecchio, Laura M., Goldstein, David S., Guillot, Thomas S., Salahpour, Ali, Miller, Gary W.

“…Disruption of neurotransmitter vesicle dynamics (transport, capacity, release) has been implicated in a variety of neurodegenerative and neuropsychiatric…”
Get full text

Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor by Espinoza, Stefano, Salahpour, Ali, Masri, Bernard, Sotnikova, Tatyana D, Messa, Mirko, Barak, Larry S, Caron, Marc G, Gainetdinov, Raul R

“…The ability of dopamine receptors to interact with other receptor subtypes may provide mechanisms for modulating dopamine-related functions and behaviors. In…”
Get more information

Antagonism of dopamine D2 receptor/β-arrestin 2 interaction is a common property of clinically effective antipsychotics by Masri, Bernard, Salahpour, Ali, Didriksen, Michael, Ghisi, Valentina, Beaulieu, Jean-Martin, Gainetdinov, Raul R, Caron, Marc G

“…Since the unexpected discovery of the antipsychotic activity of chlorpromazine, a variety of therapeutic agents have been developed for the treatment of…”
Get full text

Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo by Vecchio, Laura M., Sullivan, Patricia, Dunn, Amy R., Bermejo, Marie Kristel, Fu, Rong, Masoud, Shababa T., Gregersen, Emil, Urs, Nikhil M., Nazari, Reza, Jensen, Poul Henning, Ramsey, Amy, Goldstein, David S., Miller, Gary W., Salahpour, Ali

“…In Parkinson's disease, dopamine‐containing nigrostriatal neurons undergo profound degeneration. Tyrosine hydroxylase (TH) is the rate‐limiting enzyme in…”
Get full text

Progressive neuroanatomical changes caused by Grin1 loss-of-function mutation by Intson, Katheron, van Eede, Matthijs C., Islam, Rehnuma, Milenkovic, Marija, Yan, Yuanye, Salahpour, Ali, Henkelman, R. Mark, Ramsey, Amy J.

“…NMDA receptor dysfunction is central to the encephalopathies caused by missense mutations in the NMDA receptor subunit genes. Missense variants of GRIN1,…”
Get full text

Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function by Angers, Stephane, Salahpour, Ali, Bouvier, Michel

“…In the last four to five years, the view that G protein-coupled receptors (GPCRs) function as monomeric proteins has been challenged by numerous studies, which…”
Get full text

Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer by Mercier, Jean-François, Salahpour, Ali, Angers, Stéphane, Breit, Andreas, Bouvier, Michel

Get full text

A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models by Mielnik, Catharine A., Sugamori, Kim S., Finlay, David B., Thorpe, Hayley H. A., Schapira, Matthieu, Sivananthan, Nirunthan, Li, Chun Kit, Lam, Vincent M., Harrington, Sean, Abdelrahman, Mostafa H., Trembleau, Laurent A., McIntyre Burnham, W., Khokhar, Jibran Y., Salahpour, Ali, Ramsey, Amy J., Glass, Michelle, Greig, Iain R., Ross, Ruth A.

“…Abstract The endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors. The eCBs…”
Get full text

Homodimerization of the β2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting by Salahpour, Ali, Angers, Stéphane, Mercier, Jean-François, Lagacé, Monique, Marullo, Stefano, Bouvier, Michel

“…Although homodimerization has been demonstrated for a large number of G protein-coupled receptors (GPCRs), no general role has been attributed to this process…”
Get full text

Detection of β2-Adrenergic Receptor Dimerization in Living Cells Using Bioluminescence Resonance Energy Transfer (BRET) by Angers, Stephane, Salahpour, Ali, Joly, Eric, Hilairet, Sandrine, Chelsky, Dan, Dennis, Michael, Bouvier, Michel

“…Heptahelical receptors that interact with heterotrimeric G proteins represent the largest family of proteins involved in signal transduction across biological…”
Get full text

Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice by Chen, Yuxiao, Milenkovic, Marija, Horsfall, Wendy, Salahpour, Ali, Soderling, Scott H, Ramsey, Amy J

“…NMDA receptors are important for cognition and are implicated in neuropsychiatric disorders. GluN1 knockdown (GluN1KD) mice have reduced NMDA receptor levels,…”
Get full text

Structure-Activity Relationships of Dopamine Transporter Pharmacological Chaperones by Sutton, Charles, Williams, Erin Q, Homsi, Hoomam, Beerepoot, Pieter, Nazari, Reza, Han, Dong, Ramsey, Amy J, Mash, Deborah C, Olson, David E, Blough, Bruce, Salahpour, Ali

“…Mutations in the dopamine transporter gene (SLC6A3) have been implicated in many human diseases. Among these is the infantile parkinsonism-dystonia known as…”
Get full text

Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity by Lohr, Kelly M, Stout, Kristen A, Dunn, Amy R, Wang, Minzheng, Salahpour, Ali, Guillot, Thomas S, Miller, Gary W

“…The psychostimulant methamphetamine (METH) is highly addictive and neurotoxic to dopamine terminals. METH toxicity has been suggested to be due to the release…”
Get full text

Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter by Salahpour, Ali, Ramsey, Amy J, Medvedev, Ivan O, Kile, Brian, Sotnikova, Tatyana D, Holmstrand, Ericka, Ghisi, Valentina, Nicholls, Peter J, Wong, Ling, Murphy, Karen, Sesack, Susan R, Wightman, R. Mark, Gainetdinov, Raul R, Caron, Marc G

“…The dopamine transporter (DAT) plays a key role in the regulation of dopaminergic signaling wherein it controls both the spatial and temporal actions of…”
Get full text

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner by Ramsey, Amy J, Milenkovic, Marija, Oliveira, Ana F, Escobedo-Lozoya, Yasmin, Seshadri, Saurav, Salahpour, Ali, Sawa, Akira, Yasuda, Ryohei, Caron, Marc G

“…NMDA receptors are key regulators of synaptic plasticity, and their hypofunction is thought to contribute to the pathophysiology of CNS disorders. Furthermore,…”
Get full text

The dopamine metabolite 3-methoxytyramine is a neuromodulator by Sotnikova, Tatyana D, Beaulieu, Jean-Martin, Espinoza, Stefano, Masri, Bernard, Zhang, Xiaodong, Salahpour, Ali, Barak, Larry S, Caron, Marc G, Gainetdinov, Raul R

“…Dopamine (3-hydroxytyramine) is a well-known catecholamine neurotransmitter involved in multiple physiological functions including movement control. Here we…”
Get full text

Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor by Barak, Larry S, Salahpour, Ali, Zhang, Xiaodong, Masri, Bernard, Sotnikova, Tatyana D, Ramsey, Amy J, Violin, Jonathan D, Lefkowitz, Robert J, Caron, Marc G, Gainetdinov, Raul R

“…Trace amines are neurotransmitters whose role in regulating invertebrate physiology has been appreciated for many decades. Recent studies indicate that trace…”
Get more information

Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo by Kelly M. Lohr, Alison I. Bernstein, Kristen A. Stout, Amy R. Dunn, Carlos R. Lazo, Shawn P. Alter, Minzheng Wang, Yingjie Li, Xueliang Fan, Ellen J. Hess, Hong Yi, Laura M. Vecchio, David S. Goldstein, Thomas S. Guillot, Ali Salahpour, Gary W. Miller

Get full text