Search Results - "Ali Hosseini Rad, S M"

Promoter choice: Who should drive the CAR in T cells? by Rad S. M., Ali Hosseini, Poudel, Aarati, Tan, Grace Min Yi, McLellan, Alexander D

“…Chimeric antigen receptor (CAR) T cell therapy is an effective treatment for B cell malignancies, with emerging potential for the treatment of other…”
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Optimisation of Tet-On inducible systems for Sleeping Beauty-based chimeric antigen receptor (CAR) applications by Ali Hosseini Rad, S. M., Poudel, Aarati, Tan, Grace Min Yi, McLellan, Alexander D.

“…Regulated expression of genetic elements that either encode polypeptides or various types of functional RNA is a fundamental goal for gene therapy. Inducible…”
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Tracing the transmission of mpox through wastewater surveillance in Southeast Asia by Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Chadsuthi, Sudarat, Anupong, Suparinthon, Miyanaga, Kazuhiko, Cui, Longzhu, Thuptimdang, Wanwara, Ali Hosseini Rad, S M, Fernandez, Stefan, Huang, Angkana T, Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Ounjai, Puey, Ragupathi, Naveen Kumar Devanga, Kanthawee, Phitsanuruk, Sano, Daisuke, Furukawa, Takashi, Sei, Kazunari, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Higgins, Paul G, Nanbo, Asuka, Kicic, Anthony, Singer, Andrew C, Chatsuwan, Tanittha, Trowsdale, Sam, Siow, Richard, Shibuya, Kenji, Abe, Shuichi, Ishikawa, Hitoshi, Hongsing, Parichart

“…Abstract High population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance in…”
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Noise-Reduction and Sensitivity-Enhancement of a Sleeping Beauty-Based Tet-On System by Saunderson, Sarah C, Hosseini-Rad, SM Ali, McLellan, Alexander D

“…Tetracycline-inducible systems are widely used control elements for mammalian gene expression. Despite multiple iterations to improve inducibility, their use…”
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Implications of SARS-CoV-2 Mutations for Genomic RNA Structure and Host microRNA Targeting by Hosseini Rad Sm, Ali, McLellan, Alexander D

“…The SARS-CoV-2 virus is a recently-emerged zoonotic pathogen already well adapted to transmission and replication in humans. Although the mutation rate is…”
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The impact of non-synonymous mutations on miRNA binding sites within the SARS-CoV-2 NSP3 and NSP4 genes by Rad, S. M. Ali Hosseini, Wannigama, Dhammika Leshan, Hirankarn, Nattiya, McLellan, Alexander D.

“…Non-synonymous mutations in the SARS-CoV-2 spike region affect cell entry, tropism, and immune evasion, while frequent synonymous mutations may modify viral…”
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Regulation of human Mcl-1 by a divergently-expressed antisense transcript by Ali Hosseini Rad, S.M., Min Yi Tan, Grace, Poudel, Aarati, He, Kevin, McLellan, Alexander D.

“…•Mcl-1 expression is negatively regulated by an antisense transcript (Mcl1-AS1)•Mcl1-AS1 is predicted to bind to Mcl-1 mRNA.•The first exon and intron act as a…”
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Compact Bidirectional Promoters for Dual-Gene Expression in a Sleeping Beauty Transposon by He, Kevin, Rad, S M Ali Hosseini, Poudel, Aarati, McLellan, Alexander Donald

“…Promoter choice is an essential consideration for transgene expression in gene therapy. The expression of multiple genes requires ribosomal entry or skip…”
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Optimization of anti-TIM3 chimeric antigen receptor with CD8α spacer and TNFR-based costimulation for enhanced efficacy in AML therapy by Pe, Kristine Cate S., Jewmoung, Sirirut, Rad, SM Ali Hosseini, Chantarat, Natthida, Chanswangphuwana, Chantiya, Tashiro, Haruko, Suppipat, Koramit, Tawinwung, Supannikar

“…CAR T cell therapy for AML remains limited due to the lack of a proper target without on-target off-tumor toxicity. TIM3 is a promising target due to its high…”
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Metabolic and Mitochondrial Functioning in Chimeric Antigen Receptor (CAR)-T Cells by Rad S M, Ali Hosseini, Halpin, Joshua Colin, Mollaei, Mojtaba, Smith Bell, Samuel W J, Hirankarn, Nattiya, McLellan, Alexander D

“…Chimeric antigen receptor (CAR) T-cell therapy has revolutionized adoptive cell therapy with impressive therapeutic outcomes of >80% complete remission (CR)…”
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Tracing the new SARS-CoV-2 variant BA.2.86 in the community through wastewater surveillance in Bangkok, Thailand by Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Chadsuthi, Sudarat, Anupong, Suparinthon, Miyanaga, Kazuhiko, Cui, Longzhu, Fernandez, Stefan, Huang, Angkana T, Ounjai, Puey, Tacharoenmuang, Ratana, Ragupathi, Naveen Kumar Devanga, Sano, Daisuke, Furukawa, Takashi, Sei, Kazunari, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Higgins, Paul G, Nanbo, Asuka, Kicic, Anthony, Singer, Andrew C, Chatsuwan, Tanittha, Trowsdale, Sam, Khatib, Aisha, Shibuya, Kenji, Abe, Shuichi, Ishikawa, Hitoshi, Hongsing, Parichart, Thuptiang, Wanwara, Rad S M, Ali Hosseini, Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Kanthawee, Phitsanuruk

“…[...]complementary surveillance methods such as wastewater-based epidemiological surveillance offer timely insights into virus circulation.2–5 To assess the…”
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Multiple traces of monkeypox detected in non-sewered wastewater with sparse sampling from a densely populated metropolitan area in Asia by Wannigama, Dhammika Leshan, Amarasiri, Mohan, Hongsing, Parichart, Hurst, Cameron, Modchang, Charin, Chadsuthi, Sudarat, Anupong, Suparinthon, Phattharapornjaroen, Phatthranit, S.M., Ali Hosseini Rad, Fernandez, Stefan, Huang, Angkana T., Kueakulpattana, Naris, Tanasatitchai, Chanikan, Vatanaprasan, Porames, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Ounjai, Puey, Ragupathi, Naveen Kumar Devanga, Kanthawee, Phitsanuruk, Sano, Daisuke, Furukawa, Takashi, Sei, Kazunari, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Hirankarn, Nattiya, Higgins, Paul G., Kicic, Anthony, Chatsuwan, Tanittha, McLellan, Alexander D., Abe, Shuichi

“…The monkeypox virus is excreted in the feces of infected individuals. Therefore, there is an interest in using viral load detection in wastewater for sentinel…”
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Tracking COVID-19 with wastewater to understand asymptomatic transmission by Wannigama, Dhammika Leshan, Amarasiri, Mohan, Hurst, Cameron, Phattharapornjaroen, Phatthranit, Abe, Shuichi, Hongsing, Parichart, Rad, S.M. Ali Hosseini, Pearson, Lachlan, Saethang, Thammakorn, Luk-in, Sirirat, Kueakulpattana, Naris, Storer, Robin James, Ounjai, Puey, Jacquet, Alain, Leelahavanichkul, Asada, Chatsuwan, Tanittha

“…•This study provided the first dataset related to SARS-CoV-2 RNA in wastewater in Bangkok.•A rise in SARS-CoV-2 RNA level in wastewater preceded an increase in…”
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Phage cocktail amikacin combination as a potential therapy for bacteremia associated with carbapenemase producing colistin resistant Klebsiella pneumoniae by Shein, Aye Mya Sithu, Wannigama, Dhammika Leshan, Hurst, Cameron, Monk, Peter N., Amarasiri, Mohan, Wongsurawat, Thidathip, Jenjaroenpun, Piroon, Phattharapornjaroen, Phatthranit, Ditcham, William Graham Fox, Ounjai, Puey, Saethang, Thammakorn, Chantaravisoot, Naphat, Badavath, Vishnu Nayak, Luk-in, Sirirat, Nilgate, Sumanee, Rirerm, Ubolrat, Srisakul, Sukrit, Kueakulpattana, Naris, Laowansiri, Matchima, Rad, S. M. Ali Hosseini, Wacharapluesadee, Supaporn, Rodpan, Apaporn, Ngamwongsatit, Natharin, Thammahong, Arsa, Ishikawa, Hitoshi, Storer, Robin James, Leelahavanichkul, Asada, Ragupathi, Naveen Kumar Devanga, Classen, Annika Y., Kanjanabuch, Talerngsak, Pletzer, Daniel, Miyanaga, Kazuhiko, Cui, Longzhu, Hamamoto, Hiroshi, Higgins, Paul G., Kicic, Anthony, Chatsuwan, Tanittha, Hongsing, Parichart, Abe, Shuichi

“…The increasing occurrence of hospital-associated infections, particularly bacteremia, caused by extensively drug-resistant (XDR) carbapenemase-producing…”
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Wastewater-based epidemiological surveillance of SARS-CoV-2 new variants BA.2.86 and offspring JN.1 in South and Southeast Asia by Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Chadsuthi, Sudarat, Anupong, Suparinthon, Miyanaga, Kazuhiko, Cui, Longzhu, Werawatte, W K C P, Ali Hosseini Rad, S M, Fernandez, Stefan, Huang, Angkana T, Vatanaprasan, Porames, Saethang, Thammakorn, Luk-In, Sirirat, Storer, Robin James, Ounjai, Puey, Tacharoenmuang, Ratana, Ragupathi, Naveen Kumar Devanga, Kanthawee, Phitsanuruk, Cynthia, Bernadina, Besa, John Jefferson V, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Higgins, Paul G, Nanbo, Asuka, Kicic, Anthony, Singer, Andrew C, Chatsuwan, Tanittha, Trowsdale, Sam, Furukawa, Takashi, Sei, Kazunari, Sano, Daisuke, Ishikawa, Hitoshi, Shibuya, Kenji, Khatib, Aisha, Abe, Shuichi, Hongsing, Parichart

“…Discover the shifting landscape of SARS-CoV-2 variants from October to December 2023, with JN.1 dominating South and Southeast Asia wastewater samples,…”
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Exploring indoor and outdoor dust as a potential tool for detection and monitoring of COVID-19 transmission by Anupong, Suparinthon, Chadsuthi, Sudarat, Hongsing, Parichart, Hurst, Cameron, Phattharapornjaroen, Phatthranit, Rad S.M., Ali Hosseini, Fernandez, Stefan, Huang, Angkana T., Vatanaprasan, Porames, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Ounjai, Puey, Devanga Ragupathi, Naveen Kumar, Kanthawee, Phitsanuruk, Ngamwongsatit, Natharin, Badavath, Vishnu Nayak, Thuptimdang, Wanwara, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Miyanaga, Kazuhiko, Cui, Longzhu, Nanbo, Asuka, Shibuya, Kenji, Kupwiwat, Rosalyn, Sano, Daisuke, Furukawa, Takashi, Sei, Kazunari, Higgins, Paul G., Kicic, Anthony, Singer, Andrew C., Chatsuwan, Tanittha, Trowsdale, Sam, Abe, Shuichi, Ishikawa, Hitoshi, Amarasiri, Mohan, Modchang, Charin, Wannigama, Dhammika Leshan

“…This study investigated the potential of using SARS-CoV-2 viral concentrations in dust as an additional surveillance tool for early detection and monitoring of…”
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Novel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection by Shein, Aye Mya Sithu, Wannigama, Dhammika Leshan, Hurst, Cameron, Monk, Peter N., Amarasiri, Mohan, Badavath, Vishnu Nayak, Phattharapornjaroen, Phatthranit, Ditcham, William Graham Fox, Ounjai, Puey, Saethang, Thammakorn, Chantaravisoot, Naphat, Thuptimdang, Wanwara, Luk-in, Sirirat, Nilgate, Sumanee, Rirerm, Ubolrat, Tanasatitchai, Chanikan, Kueakulpattana, Naris, Laowansiri, Matchima, Liao, Tingting, Kupwiwat, Rosalyn, Rojanathanes, Rojrit, Ngamwongsatit, Natharin, Thammahong, Arsa, Ishikawa, Hitoshi, Pletzer, Daniel, Leelahavanichkul, Asada, Ragupathi, Naveen Kumar Devanga, Wapeesittipan, Pattama, Ali Hosseini Rad, S.M., Kanjanabuch, Talerngsak, Storer, Robin James, Miyanaga, Kazuhiko, Cui, Longzhu, Hamamoto, Hiroshi, Higgins, Paul G., Kicic, Anthony, Chatsuwan, Tanittha, Hongsing, Parichart, Abe, Shuichi

“…Given the rise of multidrug-resistant (MDR) Pseudomonas aeruginosa infections, alternative treatments are needed. Anti-pseudomonal phage therapy shows promise,…”
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Development of a Multiepitope Vaccine Against SARS-CoV-2: Immunoinformatics Study by Ghafouri, Fatemeh, Ahangari Cohan, Reza, Samimi, Hilda, Hosseini Rad S M, Ali, Naderi, Mahmood, Noorbakhsh, Farshid, Haghpanah, Vahid

“…BackgroundSince the first appearance of SARS-CoV-2 in China in December 2019, the world witnessed the emergence of the SARS-CoV-2 outbreak. Due to the high…”
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COVID-19 monitoring with sparse sampling of sewered and non-sewered wastewater in urban and rural communities by Wannigama, Dhammika Leshan, Amarasiri, Mohan, Hongsing, Parichart, Hurst, Cameron, Modchang, Charin, Chadsuthi, Sudarat, Anupong, Suparinthon, Phattharapornjaroen, Phatthranit, Rad S. M., Ali Hosseini, Fernandez, Stefan, Huang, Angkana T., Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Ounjai, Puey, Devanga Ragupathi, Naveen Kumar, Kanthawee, Phitsanuruk, Sano, Daisuke, Furukawa, Takashi, Sei, Kazunari, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Hirankarn, Nattiya, Higgins, Paul G., Kicic, Anthony, Singer, Andrew C., Chatsuwan, Tanittha, Trowsdale, Sam, Abe, Shuichi, McLellan, Alexander D., Ishikawa, Hitoshi

“…Equitable SARS-CoV-2 surveillance in low-resource communities lacking centralized sewers is critical as wastewater-based epidemiology (WBE) progresses…”
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Ca-EDTA restores the activity of ceftazidime-avibactam or aztreonam against carbapenemase-producing Klebsiella pneumoniae infections by Wannigama, Dhammika Leshan, Sithu Shein, Aye Mya, Hurst, Cameron, Monk, Peter N., Hongsing, Parichart, Phattharapornjaroen, Phatthranit, Fox Ditcham, William Graham, Ounjai, Puey, Saethang, Thammakorn, Chantaravisoot, Naphat, Wapeesittipan, Pattama, Luk-in, Sirirat, Sae-Joo, Sasipen, Nilgate, Sumanee, Rirerm, Ubolrat, Tanasatitchai, Chanikan, Kueakulpattana, Naris, Laowansiri, Matchima, Liao, Tingting, Kupwiwat, Rosalyn, Rojanathanes, Rojrit, Ngamwongsatit, Natharin, Tungsanga, Somkanya, Leelahavanichkul, Asada, Devanga Ragupathi, Naveen Kumar, Badavath, Vishnu Nayak, Hosseini Rad, S.M. Ali, Kanjanabuch, Talerngsak, Hirankarn, Nattiya, Storer, Robin James, Cui, Longzhu, Amarasiri, Mohan, Ishikawa, Hitoshi, Higgins, Paul G., Stick, Stephen M., Kicic, Anthony, Chatsuwan, Tanittha, Abe, Shuichi

“…Developing an effective therapy to overcome carbapenemase-positive Klebsiella pneumoniae (CPKp) is an important therapeutic challenge that must be addressed…”
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