Search Results - "Ali, Taha F.S."

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    New nitric oxide donating 1,2,4-triazole/oxime hybrids: Synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities by Abdel-Aziz, Mohamed, Abuo-Rahma, Gamal El-Din A.A., Beshr, Eman A.M., Ali, Taha F.S.

    Published in Bioorganic & medicinal chemistry (01-07-2013)
    “…A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity. Most of the tested…”
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    Journal Article
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    Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors by Abdelbaset, Mahmoud S., Abdel-Aziz, Mohamed, Ramadan, Mohamed, Abdelrahman, Mostafa H., Abbas Bukhari, Syed Nasir, Ali, Taha F.S., Abuo-Rahma, Gamal El-Din A.

    Published in Bioorganic & medicinal chemistry (15-03-2019)
    “…[Display omitted] •Novel thienoquinoline-2-carboxamide-chalcone derivatives.•Structural elucidation.•Good Antiproliferaive Activity.•EGFR-kinase…”
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    Journal Article
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    Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020 by Roshdy, Eslam, Mustafa, Muhamad, Shaltout, Abd El-Rahman, Radwan, Mohamed O., Ibrahim, Mahmoud A.A., Soliman, Mahmoud E., Fujita, Mikako, Otsuka, Masami, Ali, Taha F.S.

    Published in European journal of medicinal chemistry (15-11-2021)
    “…Sirtuin 2 (SIRT2) is a member of the human sirtuins, which regulates various biological processes and is deemed as a novel biomarker for different cancers…”
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    Cyclodextrin Enhances Corneal Tolerability and Reduces Ocular Toxicity Caused by Diclofenac by Ali, Taha F. S., Moharram, Hossam Mohamed, Fathalla, Zeinab, Abd al-Qadir, Hamdi, Pierscionek, Barbara K.

    Published in Oxidative medicine and cellular longevity (01-01-2018)
    “…With advances in refractive surgery and demand for cataract removal and lens replacement, the ocular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has…”
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    1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities by Abuo-Rahma, Gamal El-Din A.A., Abdel-Aziz, Mohamed, Beshr, Eman A.M., Ali, Taha F.S.

    Published in European journal of medicinal chemistry (01-01-2014)
    “…A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity and antiproliferative…”
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    Journal Article
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    New SIRT2 inhibitors: Histidine-based bleomycin spin-off by Ali, Taha F.S., Ciftci, Halil I., Radwan, Mohamed O., Koga, Ryoko, Ohsugi, Takeo, Okiyama, Yoshio, Honma, Teruki, Nakata, Akiko, Ito, Akihiro, Yoshida, Minoru, Fujita, Mikako, Otsuka, Masami

    Published in Bioorganic & medicinal chemistry (01-05-2019)
    “…[Display omitted] Bleomycin is considered to exert its antitumor activity via DNA cleavage mediated by activated oxygen generated from the iron complex in its…”
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    Neuroprotective effects of a novel carnosine-hydrazide derivative on hippocampal CA1 damage after transient cerebral ischemia by Noguchi, Kei, Ali, Taha F.S., Miyoshi, Junko, Orito, Kimihiko, Negoto, Tetsuya, Biswas, Tanima, Taira, Naomi, Koga, Ryoko, Okamoto, Yoshinari, Fujita, Mikako, Otsuka, Masami, Morioka, Motohiro

    Published in European journal of medicinal chemistry (01-02-2019)
    “…Ischemia-reperfusion injuries produce reactive oxygen species that promote the peroxide lipid oxidation process resulting in the production of an endogenic…”
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    The First Pentacyclic Triterpenoid Gypsogenin Derivative Exhibiting Anti-ABL1 Kinase and Anti-chronic Myelogenous Leukemia Activities by Ciftci, Halil Ibrahim, Ozturk, Safiye Emirdag, Ali, Taha F. S., Radwan, Mohamed O., Tateishi, Hiroshi, Koga, Ryoko, Ocak, Zeynep, Can, Mustafa, Otsuka, Masami, Fujita, Mikako

    Published in Biological & pharmaceutical bulletin (01-04-2018)
    “…The discovery of the chimeric tyrosine kinase breakpoint cluster region kinase-Abelson kinase (BCR-ABL)-targeted drug imatinib conceptually changed the…”
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    Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug by Aly, Usama Farghaly, Sarhan, Hatem Abdel-Monsef, Ali, Taha F S, Sharkawy, Hosny Abd El-Bakey

    Published in Drug design, development and therapy (01-01-2020)
    “…The objective of this study was to compare different techniques to enhance the solubility and dissolution rate, and hence the bioavailability of candesartan…”
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    HSP70 induction by bleomycin metal core analogs by Ali, Taha F.S., Taira, Naomi, Iwamaru, Kana, Koga, Ryoko, Kamo, Masahiro, Radwan, Mohamed O., Tateishi, Hiroshi, Kurosaki, Hiromasa, Abdel-Aziz, Mohamed, Abuo-Rahma, Gamal El-Din A.A., Beshr, Eman A.M., Otsuka, Masami, Fujita, Mikako

    Published in Bioorganic & medicinal chemistry letters (01-04-2020)
    “…[Display omitted] Induction of heat shock protein 70 (HSP70) is known to be effective against various diseases. We are interested in HSP70 induction capability…”
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    The protective role of two oxindole derivatives is mediated by modulating NLRP3/caspase-1 and PI3K/AKT pathways in a preclinical animal model of hepatic ischemia reperfusion injury by Eldafashi, Nardeen, Waaz, Shaimaa, Ali, Taha F.S., Zaki, Marco Y.W., Nazmy, Maiiada Hassan, Fathy, Moustafa

    Published in Life sciences (1973) (01-09-2024)
    “…Aim Hepatic ischemia reperfusion injury (HIRI) is a leading cause of mortality post liver transplantation, hypovolemic shock and trauma. In this study, we…”
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    Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition by Radwan, Mohamed O., Ciftci, Halil I., Ali, Taha F.S., Koga, Ryoko, Tateishi, Hiroshi, Nakata, Akiko, Ito, Akihiro, Yoshida, Minoru, Fujita, Mikako, Otsuka, Masami

    Published in Bioorganic & medicinal chemistry letters (01-10-2020)
    “…[Display omitted] Sirtuin proteins are a highly conserved class of nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases. The pleiotropic human…”
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    New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization by Ezelarab, Hend A. A., Ali, Taha F. S., Abbas, Samar H., Sayed, Ahmed M., Beshr, Eman A. M., Hassan, Heba A.

    Published in Molecular diversity (01-04-2024)
    “…New 3-substituted oxindole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of compounds 6a–j was…”
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    In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents by Ibrahim, Mahmoud A. A., Abdeljawaad, Khlood A. A., Roshdy, Eslam, Mohamed, Dina E. M., Ali, Taha F. S., Gabr, Gamal A., Jaragh-Alhadad, Laila A., Mekhemer, Gamal A. H., Shawky, Ahmed M., Sidhom, Peter A., Abdelrahman, Alaa H. M.

    Published in Scientific reports (07-02-2023)
    “…Sirtuin 2 (SIRT2) is a member of the sirtuin protein family, which includes lysine deacylases that are NAD + -dependent and organize several biological…”
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    Secondary metabolites of Livistona decipiens as potential inhibitors of SARS-CoV-2 by El-hawary, Seham S., Ali, Taha F. S., Abo El-Ela, Sara O., Elwekeel, Ahlam, Abdelmohsen, Usama Ramadan, Owis, Asmaa I.

    Published in RSC advances (29-06-2022)
    “…In late December 2019, a pandemic coronavirus disease 2019 (COVID-19) emerged in Wuhan, China and spread all over the globe. One of the promising therapeutic…”
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