Search Results - "Ali, Taha F.S."
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Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity
Published in Molecules (Basel, Switzerland) (30-09-2019)“…Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance…”
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New nitric oxide donating 1,2,4-triazole/oxime hybrids: Synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities
Published in Bioorganic & medicinal chemistry (01-07-2013)“…A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity. Most of the tested…”
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Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors
Published in Bioorganic & medicinal chemistry (15-03-2019)“…[Display omitted] •Novel thienoquinoline-2-carboxamide-chalcone derivatives.•Structural elucidation.•Good Antiproliferaive Activity.•EGFR-kinase…”
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Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020
Published in European journal of medicinal chemistry (15-11-2021)“…Sirtuin 2 (SIRT2) is a member of the human sirtuins, which regulates various biological processes and is deemed as a novel biomarker for different cancers…”
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5
Cyclodextrin Enhances Corneal Tolerability and Reduces Ocular Toxicity Caused by Diclofenac
Published in Oxidative medicine and cellular longevity (01-01-2018)“…With advances in refractive surgery and demand for cataract removal and lens replacement, the ocular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has…”
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Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers
Published in Bioorganic & medicinal chemistry (15-04-2020)“…[Display omitted] •Compound MM-1 is a promising APOBEC3G stabilizer of elusive mechanism of action.•Comprehensive in silico study revealed their potential to…”
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1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities
Published in European journal of medicinal chemistry (01-01-2014)“…A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity and antiproliferative…”
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8
New SIRT2 inhibitors: Histidine-based bleomycin spin-off
Published in Bioorganic & medicinal chemistry (01-05-2019)“…[Display omitted] Bleomycin is considered to exert its antitumor activity via DNA cleavage mediated by activated oxygen generated from the iron complex in its…”
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Neuroprotective effects of a novel carnosine-hydrazide derivative on hippocampal CA1 damage after transient cerebral ischemia
Published in European journal of medicinal chemistry (01-02-2019)“…Ischemia-reperfusion injuries produce reactive oxygen species that promote the peroxide lipid oxidation process resulting in the production of an endogenic…”
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The First Pentacyclic Triterpenoid Gypsogenin Derivative Exhibiting Anti-ABL1 Kinase and Anti-chronic Myelogenous Leukemia Activities
Published in Biological & pharmaceutical bulletin (01-04-2018)“…The discovery of the chimeric tyrosine kinase breakpoint cluster region kinase-Abelson kinase (BCR-ABL)-targeted drug imatinib conceptually changed the…”
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11
Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug
Published in Drug design, development and therapy (01-01-2020)“…The objective of this study was to compare different techniques to enhance the solubility and dissolution rate, and hence the bioavailability of candesartan…”
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12
HSP70 induction by bleomycin metal core analogs
Published in Bioorganic & medicinal chemistry letters (01-04-2020)“…[Display omitted] Induction of heat shock protein 70 (HSP70) is known to be effective against various diseases. We are interested in HSP70 induction capability…”
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The protective role of two oxindole derivatives is mediated by modulating NLRP3/caspase-1 and PI3K/AKT pathways in a preclinical animal model of hepatic ischemia reperfusion injury
Published in Life sciences (1973) (01-09-2024)“…Aim Hepatic ischemia reperfusion injury (HIRI) is a leading cause of mortality post liver transplantation, hypovolemic shock and trauma. In this study, we…”
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Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition
Published in Bioorganic & medicinal chemistry letters (01-10-2020)“…[Display omitted] Sirtuin proteins are a highly conserved class of nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases. The pleiotropic human…”
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In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors
Published in Molecules (Basel, Switzerland) (07-11-2020)“…Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1…”
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New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization
Published in Molecular diversity (01-04-2024)“…New 3-substituted oxindole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of compounds 6a–j was…”
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In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents
Published in Scientific reports (07-02-2023)“…Sirtuin 2 (SIRT2) is a member of the sirtuin protein family, which includes lysine deacylases that are NAD + -dependent and organize several biological…”
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Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
Published in Molecules (Basel, Switzerland) (27-12-2017)“…In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple…”
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Secondary metabolites of Livistona decipiens as potential inhibitors of SARS-CoV-2
Published in RSC advances (29-06-2022)“…In late December 2019, a pandemic coronavirus disease 2019 (COVID-19) emerged in Wuhan, China and spread all over the globe. One of the promising therapeutic…”
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Discovery of oxindole‐based FLT3 inhibitors as a promising therapeutic lead for acute myeloid leukemia carrying the oncogenic ITD mutation
Published in Archiv der Pharmazie (Weinheim) (01-02-2023)“…FMS‐like tyrosine kinase 3 (FLT3) mutations occur in approximately 30% of acute myeloid leukemia (AML) patients. In the current study, the oxindole chemotype…”
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