Search Results - "Ali, Syed Shujait"
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Structural insights into the mechanism of RNA recognition by the N-terminal RNA-binding domain of the SARS-CoV-2 nucleocapsid phosphoprotein
Published in Computational and structural biotechnology journal (01-01-2020)“…[Display omitted] The emergence of recent SARS-CoV-2 has become a global health issue. This single-stranded positive-sense RNA virus is continuously spreading…”
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Sustainable production of biomass and industrially important secondary metabolites in cell cultures of selfheal (Prunella vulgaris L.) elicited by silver and gold nanoparticles
Published in Artificial cells, nanomedicine, and biotechnology (01-12-2019)“…Elicited artificial in vitro cultures are gaining more interest due to their uniform biosynthesis of industrially valuable secondary metabolites. In this…”
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Global Burden of Cardiovascular Diseases and Risks, 1990-2022
Published in Journal of the American College of Cardiology (19-12-2023)Get full text
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Out of Africa: Miocene Dispersal, Vicariance, and Extinction within Hyacinthaceae Subfamily Urgineoideae
Published in Journal of integrative plant biology (01-10-2013)“…Disjunct distribution patterns in plant lineages are usually explained according to three hypotheses: vicariance, geodispersal, and long-distance dispersal…”
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SARS-CoV-2 new variants: Characteristic features and impact on the efficacy of different vaccines
Published in Biomedicine & pharmacotherapy (01-11-2021)“…The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new variants reported in different countries have posed a serious threat…”
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Computational identification, characterization and validation of potential antigenic peptide vaccines from hrHPVs E6 proteins using immunoinformatics and computational systems biology approaches
Published in PloS one (01-05-2018)“…High-risk human papillomaviruses (hrHPVs) are the most prevalent viruses in human diseases including cervical cancers. Expression of E6 protein has already…”
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Exploring the Dynamic Interplay of Deleterious Variants on the RAF1 – RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics
Published in Proteins, structure, function, and bioinformatics (05-11-2024)“…ABSTRACT The RAF1–RAP1A interaction activates the MAPK/ERK pathway which is very crucial in the carcinogenesis process. This protein complex influences tumor…”
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Phylogenetic Analysis and Structural Perspectives of RNA-Dependent RNA-Polymerase Inhibition from SARs-CoV-2 with Natural Products
Published in Interdisciplinary sciences : computational life sciences (01-09-2020)“…Most recently, an outbreak of severe pneumonia caused by the infection of SARS-CoV-2, a novel coronavirus first identified in Wuhan, China, imposes serious…”
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Immunoinformatic and systems biology approaches to predict and validate peptide vaccines against Epstein–Barr virus (EBV)
Published in Scientific reports (24-01-2019)“…Epstein–Barr virus (EBV), also known as human herpesvirus 4 (HHV-4), is a member of the Herpesviridae family and causes infectious mononucleosis, Burkitt’s…”
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Analysis of the Aflatoxin M1 contamination in traditional and commercial cheeses consumed in Yemen
Published in International journal of dairy technology (01-02-2022)“…The current study aimed to determine the levels of Aflatoxin M1 in traditional Taizi cheese and commercial cheeses utilised in Yemen. A total of 273 cheese…”
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Ultra-Large-Scale Screening of Natural Compounds and Free Energy Calculations Revealed Potential Inhibitors for the Receptor-Binding Domain (RBD) of SARS-CoV-2
Published in Molecules (Basel, Switzerland) (28-10-2022)“…The emergence of immune-evading variants of SARS-CoV-2 further aggravated the ongoing pandemic. Despite the deployments of various vaccines, the acquired…”
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Sequence-structure functional implications and molecular simulation of high deleterious nonsynonymous substitutions in IDH1 revealed the mechanism of drug resistance in glioma
Published in Frontiers in pharmacology (16-09-2022)“…In the past few years, various somatic point mutations of isocitrate dehydrogenase (IDH) encoding genes (IDH1 and IDH2) have been identified in a broad range…”
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An Integrated Systems Biology and Network-Based Approaches to Identify Novel Biomarkers in Breast Cancer Cell Lines Using Gene Expression Data
Published in Interdisciplinary sciences : computational life sciences (01-06-2020)“…Breast cancer is the most common cause of death in women worldwide. Approximately 5%–10% of instances are attributed to mutations acquired from the parents…”
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Mutational Landscape of Pirin and Elucidation of the Impact of Most Detrimental Missense Variants That Accelerate the Breast Cancer Pathways: A Computational Modelling Study
Published in Frontiers in molecular biosciences (28-06-2021)“…Pirin ( PIR ) protein is highly conserved in both prokaryotic and eukaryotic organisms. Recently, it has been identified that PIR positively regulates breast…”
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Dynamics Insights Into the Gain of Flexibility by Helix-12 in ESR1 as a Mechanism of Resistance to Drugs in Breast Cancer Cell Lines
Published in Frontiers in molecular biosciences (24-01-2020)“…Incidents of breast cancer (BC) are on the rise on a daily basis and have proven to be the most prevelant cause of death for women in both developed and…”
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In Silico Mutagenesis-Based Remodelling of SARS-CoV-1 Peptide (ATLQAIAS) to Inhibit SARS-CoV-2: Structural-Dynamics and Free Energy Calculations
Published in Interdisciplinary sciences : computational life sciences (01-09-2021)“…The prolific spread of COVID-19 caused by a novel coronavirus (SARS-CoV-2) from its epicenter in Wuhan, China, to every nook and cranny of the world after…”
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Exploring the medicinal potential of Dark Chemical Matters (DCM) to design promising inhibitors for PLpro of SARS-CoV-2 using molecular screening and simulation approaches
Published in Saudi pharmaceutical journal (01-10-2023)“…The growing concerns and cases of COVID-19 with the appearance of novel variants i.e., BA.2.75. BA.5 and XBB have prompted demand for more effective treatment…”
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Heavy Metals and Microbial Diversity: A Comparative Analysis of Rivers Swat and Kabul
Published in Water (Basel) (01-09-2023)“…Water contamination with heavy metals seriously affects water and sediment quality and may affect the aquatic biota. This study assessed the impact of heavy…”
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Effect of Gibberellic Acid on Production of Biomass, Polyphenolics and Steviol Glycosides in Adventitious Root Cultures of Stevia rebaudiana (Bert.)
Published in Plants (Basel) (30-03-2020)“…In current study, the effect of gibberellic acid was tested for production of biomass, polyphenolics and Steviol glycosides in adventitious root cultures of …”
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Structural vaccinology-based design of multi-epitopes vaccine against Streptococcus gordonii and validation using molecular modeling and immune simulation approaches
Published in Heliyon (01-05-2023)“…Streptococcus gordonii is an oral bacterium colonizing the dental cavity and leading to plaque formation. This pervasive colonizer is also the etiologic agent…”
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