Efficacy of combined intravitreal bevacizumab and triamcinolone for branch retinal vein occlusion

To evaluate the efficacy of combined treatment with intravitreal bevacizumab (IVB) and triamcinolone acetate (IVT) for patients with macular edema secondary to branch retinal vein occlusion (BRVO). Retrospective analysis of 20 eyes injected with 1.25 mg IVB and 2 mg IVT for clinically identified BRV...

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Bibliographic Details
Published in:	Indian journal of ophthalmology Vol. 62; no. 4; pp. 396 - 399
Main Authors:	Ali, Rasha I, Kapoor, Kapil G, Khan, Adeel N, Gibran, Syed K
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 01-04-2014 Medknow Publications & Media Pvt. Ltd Medknow Publications & Media Pvt Ltd Wolters Kluwer Medknow Publications
Subjects:	Angiogenesis Inhibitors - administration & dosage Antibodies, Monoclonal, Humanized - administration & dosage Antimicrobial effect Bevacizumab branch retinal vein occlusion Clinical trials conventional silicone oil Diabetes Diabetic retinopathy Dosage and administration Dose-Response Relationship, Drug Drug therapy Drug Therapy, Combination endophthalmitis agents Female Follow-Up Studies Free radicals Glucocorticoids - administration & dosage heavy silicone oil Humans Hypertension intravitreal Intravitreal Injections Ischemia Keratoconus Macular degeneration macular edema Male Mean deviation Middle Aged modified deep anterior lamellar keratoplasty non-proliferative diabetic retinopathy Original Patient outcomes Patients Permeability Pharmaceutical industry Retinal diseases Retinal Vein Occlusion - drug therapy Retinal Vein Occlusion - pathology Retrospective Studies short fluctuations short wave automated perimetry standard automated perimetry steep corneal curvature Studies Tomography, Optical Coherence Treatment Outcome Triamcinolone Triamcinolone Acetonide - administration & dosage Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Veins & arteries Visual Acuity
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Summary:	To evaluate the efficacy of combined treatment with intravitreal bevacizumab (IVB) and triamcinolone acetate (IVT) for patients with macular edema secondary to branch retinal vein occlusion (BRVO). Retrospective analysis of 20 eyes injected with 1.25 mg IVB and 2 mg IVT for clinically identified BRVO within 8 weeks of onset. All patients lacked concomitant ocular pathology and completed 6 months' follow-up. Clinical examination including LogMAR visual acuity (VA) and central macular thickness (CMT) by spectralis optical coherence tomography (OCT) was performed preoperatively and at 1, 3 and 6 months post-operatively. Mean patient age was 61.3 years with a mean BRVO diagnosis time of 3 weeks at presentation. VA improved from logMAR 1.08 preoperatively to Mean logMAR VA of 0.55 ± 0.17 at 1 month (P < 0.001), 0.56 ± 0.21 at 3 months (P < 0.001), and 0.38 ± 0.1 at 6 months (P < 0.001) Mean CMT improved from 482 ± 107 μm preoperatively to 319 ± 53 μm at 1 month (P < 0.001), 344 ± 89 μm at 3 months (P < 0.001), and 241 ± 29 μm at 6 months (P < 0.001). Mean IOP preoperatively was 16.5 mmHg, 21 mmHg at 1 month, and 15 mmHg at 6 months. Six out of 20 patients (30%) were re-injected with IVB and IVT at 3 months. Early combined treatment with IVB and IVT is effective in improving anatomic and functional outcomes in patients with macular edema secondary to BRVO.
ISSN:	0301-4738 1998-3689
DOI:	10.4103/0301-4738.120227