Assessment of drug-susceptible and multidrug-resistant tuberculosis (MDR-TB) in the Central Region of Somalia: A 3-year retrospective study

BACKGROUNDMultidrug-resistant tuberculosis (MDR-TB) remains a public health emergency and a threat globally. Although increasing MDR-TB cases have been recently reported in Somalia, limited information is known. This study aims to determine the prevalence of drug-susceptible and MDR-TB in suspected...

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Published in:	PLOS global public health Vol. 3; no. 9; p. e0002319
Main Authors:	Mohamed, Mohamed Abdelrahman, Ali, Omer Abdikarin, Osman, Aamir Muse, Abatcha, Mustapha Goni, Ahmed, Abdirahman Abdirizak, Ali, Ali Mohamed, Dirie, Abdifatah Ahmed, de Oliveira, Celso José Bruno, Osman, Abdinasir Yusuf, Wang, Shu-Hua, Vieira, Rafael F. C.
Format:	Journal Article
Language:	English
Published:	San Francisco, CA USA Public Library of Science 07-09-2023 Public Library of Science (PLoS)
Subjects:	Biology and Life Sciences Medicine and Health Sciences People and Places Research and Analysis Methods
Online Access:	Get full text
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Summary:	BACKGROUNDMultidrug-resistant tuberculosis (MDR-TB) remains a public health emergency and a threat globally. Although increasing MDR-TB cases have been recently reported in Somalia, limited information is known. This study aims to determine the prevalence of drug-susceptible and MDR-TB in suspected patients referred to the TB Department in Mudug Hospital, Galkayo, Somalia, and identify potential factors associated with MDR-TB. METHODSA 3-year hospital laboratory-based retrospective study was conducted by manually reviewing laboratory records of Mycobacterium tuberculosis specimens and GeneXpert MTB/RIF results from January 2019 to December 2021 at the reference mycobacteria laboratory department in Mudug Hospital. RESULTSA total of 714 positive GeneXpert-MTB results were identified: 619 (86.7%) were drug susceptible (no Rifampin resistance [RR] detected) and 95 (13.3%) with RR detected or defined as MDR-TB. Most of the MDR-TB patients were males (71.6%, 68/95) and between the ages of 15 to 24 (31.6%, 30/95). Most isolates were collected in 2021 (43.2%, 41/95). Multivariate analyses show no significant difference between patients having MDR-TB and/or drug-susceptible TB for all variables. CONCLUSIONThis study showed an alarming frequency of MDR-TB cases among M. tuberculosis-positive patients at a regional TB reference laboratory in central Somalia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors have declared that no competing interests exist. MAM and CJBO also contributed equally to this work.
ISSN:	2767-3375 2767-3375
DOI:	10.1371/journal.pgph.0002319