Search Results - "Ali, Naveid"

Less label, more free: Approaches in label-free quantitative mass spectrometry by Neilson, Karlie A, Ali, Naveid A, Muralidharan, Sridevi, Mirzaei, Mehdi, Mariani, Michael, Assadourian, Gariné, Lee, Albert, van Sluyter, Steven C, Haynes, Paul A

“…In this review we examine techniques, software, and statistical analyses used in label-free quantitative proteomics studies for area under the curve and…”
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Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells by Lohraseb, Iman, McCarthy, Peter, Secker, Genevieve, Marchant, Ceilidh, Wu, Jianmin, Ali, Naveid, Kumar, Sharad, Daly, Roger J., Harvey, Natasha L., Kawabe, Hiroshi, Kleifeld, Oded, Wiszniak, Sophie, Schwarz, Quenten

“…The ubiquitin ligase NEDD4 promotes neural crest cell (NCC) survival and stem-cell like properties to regulate craniofacial and peripheral nervous system…”
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Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer by Junankar, Simon, Shay, Gemma, Jurczyluk, Julie, Ali, Naveid, Down, Jenny, Pocock, Nicholas, Parker, Andrew, Nguyen, Akira, Sun, Shuting, Kashemirov, Boris, McKenna, Charles E, Croucher, Peter I, Swarbrick, Alexander, Weilbaecher, Katherine, Phan, Tri Giang, Rogers, Michael J

“…Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton…”
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Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain by García-Palmero, Irene, Shah, Neelam, Ali, Naveid A., Daly, Roger J., Wilce, Jacqueline A., Villalobo, Antonio

“…Growth factor receptor bound protein 7 (Grb7) is a mammalian adaptor protein participating in signaling pathways implicated in cell migration, metastatic…”
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Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs by McCloy, Rachael A., Parker, Benjamin L., Rogers, Samuel, Chaudhuri, Rima, Gayevskiy, Velimir, Hoffman, Nolan J., Ali, Naveid, Watkins, D. Neil, Daly, Roger J., James, David E., Lorca, Thierry, Castro, Anna, Burgess, Andrew

“…Entry into mitosis is driven by the coordinated phosphorylation of thousands of proteins. For the cell to complete mitosis and divide into two identical…”
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Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway by CROUCHER, David R, HOCHGRÄFE, Falko, SHEARER, Robert, GALLEGO-ORTEGA, David, SAUNDERS, Darren N, SWARBRICK, Alexander, DALY, Roger J, LUXI ZHANG, LING LIU, LYONS, Ruth J, RICKWOOD, Danny, TACTACAN, Carole M, BROWNE, Brigid C, ALI, Naveid, CHAN, Howard

“…Basal breast cancer cells feature high expression of the Src family kinase Lyn that has been implicated in the pathogenicity of this disease. In this study, we…”
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Quantitative phosphoproteomics of transforming growth factor-β signaling in colon cancer cells by Ali, Naveid A., Molloy, Mark P.

“…The transforming growth factor‐β (TGF‐β) signaling pathway progresses through a series of protein phosphorylation regulated steps. Smad4 is a key mediator of…”
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The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking by Belle, Leila, Ali, Naveid, Lonic, Ana, Li, Xiaochun, Paltridge, James L, Roslan, Suraya, Herrmann, David, Conway, James R W, Gehling, Freya K, Bert, Andrew G, Crocker, Lesley A, Tsykin, Anna, Farshid, Gelareh, Goodall, Gregory J, Timpson, Paul, Daly, Roger J, Khew-Goodall, Yeesim

“…Factors secreted by tumor cells shape the local microenvironment to promote invasion and metastasis, as well as condition the premetastatic niche to enable…”
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Characterization of the Novel Broad-Spectrum Kinase Inhibitor CTx-0294885 As an Affinity Reagent for Mass Spectrometry-Based Kinome Profiling by Zhang, Luxi, Holmes, Ian P, Hochgräfe, Falko, Walker, Scott R, Ali, Naveid A, Humphrey, Emily S, Wu, Jianmin, de Silva, Melanie, Kersten, Wilhelmus J. A, Connor, Theresa, Falk, Hendrik, Allan, Lynda, Street, Ian P, Bentley, John D, Pilling, Patricia A, Monahan, Brendon J, Peat, Thomas S, Daly, Roger J

“…Kinase enrichment utilizing broad-spectrum kinase inhibitors enables the identification of large proportions of the expressed kinome by mass spectrometry…”
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Global characterization of signalling networks associated with tamoxifen resistance in breast cancer by Browne, Brigid C, Hochgräfe, Falko, Wu, Jianmin, Millar, Ewan K. A, Barraclough, Jane, Stone, Andrew, McCloy, Rachael A, Lee, Christine S, Roberts, Caroline, Ali, Naveid A, Boulghourjian, Alice, Schmich, Fabian, Linding, Rune, Farrow, Lynn, Gee, Julia M. W, Nicholson, Robert I, O'Toole, Sandra A, Sutherland, Robert L, Musgrove, Elizabeth A, Butt, Alison J, Daly, Roger J

“…Acquired resistance to the anti‐estrogen tamoxifen remains a significant challenge in breast cancer management. In this study, we used an integrative approach…”
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Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways by Ali, Naveid A, Wu, Jianmin, Hochgräfe, Falko, Chan, Howard, Nair, Radhika, Ye, Sunny, Zhang, Luxi, Lyons, Ruth J, Pinese, Mark, Lee, Hong Ching, Armstrong, Nicola, Ormandy, Christopher J, Clark, Susan J, Swarbrick, Alexander, Daly, Roger J

“…Although aberrant tyrosine kinase signalling characterises particular breast cancer subtypes, a global analysis of tyrosine phosphorylation in mouse models of…”
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Proteomics of Smad4 regulated transforming growth factor-beta signalling in colon cancer cells by Ali, Naveid Ahmad, McKay, Matthew John, Molloy, Mark Paul

“…TGF-β signalling can play a paradoxical cell type specific role in cancer progression. Smad4 is a key mediator of the TGF-β pathway, and is mutated and/or…”
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Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases by Jurczyluk, Julie, Munoz, Marcia A, Skinner, Oliver P, Chai, Ryan C, Ali, Naveid, Palendira, Umaimainthan, Quinn, Julian MW, Preston, Alexandra, Tangye, Stuart G, Brown, Andrew J, Argent, Elizabeth, Ziegler, John B, Mehr, Sam, Rogers, Michael J

“…Mevalonate kinase deficiency (MKD) is caused by mutations in a key enzyme of the mevalonate–cholesterol biosynthesis pathway, leading to recurrent…”
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Quantitative phosphoproteomics of transforming growth factor-[beta] signaling in colon cancer cells by Ali, Naveid A, Molloy, Mark P

“…The transforming growth factor-[beta] (TGF-[beta]) signaling pathway progresses through a series of protein phosphorylation regulated steps. Smad4 is a key…”
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Quantitative phosphoproteomics of transforming growth factor- Delta b signaling in colon cancer cells by Ali, Naveid A, Molloy, Mark P

“…The transforming growth factor- Delta *b (TGF- Delta *b) signaling pathway progresses through a series of protein phosphorylation regulated steps. Smad4 is a…”
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A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton by Ali, Naveid, Jurczyluk, Julie, Shay, Gemma, Tnimov, Zakir, Alexandrov, Kirill, Munoz, Marcia A, Skinner, Oliver P, Pavlos, Nathan J, Rogers, Michael J

“…Bisphosphonate drugs such as zoledronic acid (ZOL), used for the treatment of common bone disorders, target the skeleton and inhibit bone resorption by…”
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