Search Results - "Ali, Mohammad A.M."

COVID-19 and thrombosis: From bench to bedside by Ali, Mohammad A.M., Spinler, Sarah A.

“…Coronavirus disease of 2019 (COVID-19) is the respiratory viral infection caused by the coronavirus SARS-CoV2 (Severe Acute Respiratory Syndrome Coronavirus…”
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RYBP Is a K63-Ubiquitin-Chain-Binding Protein that Inhibits Homologous Recombination Repair by Ali, Mohammad A.M., Strickfaden, Hilmar, Lee, Brian L., Spyracopoulos, Leo, Hendzel, Michael J.

“…Ring1-YY1-binding protein (RYBP) is a member of the non-canonical polycomb repressive complex 1 (PRC1), and like other PRC1 members, it is best described as a…”
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Cardiac Sarcomeric Proteins: Novel Intracellular Targets of Matrix Metalloproteinase-2 in Heart Disease by Ali, Mohammad A.M, Fan, Xiaohu, Schulz, Richard

“…Matrix metalloproteinases (MMPs) have been almost exclusively thought to be secreted proteases (with the exception of the membrane-type MMPs) that exert…”
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Mechanisms of cytosolic targeting of matrix metalloproteinase-2 by Ali, Mohammad A.M., Chow, Ava K., Kandasamy, Arulmozhi D., Fan, Xiaohu, West, Lori J., Crawford, Bryan D., Simmen, Thomas, Schulz, Richard

“…Matrix metalloproteinase‐2 (MMP‐2) is best understood for its biological actions outside the cell. However, MMP‐2 also localizes to intracellular compartments…”
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Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity by Ali, Mohammad A.M., Stepanko, Alesandra, Fan, Xiaohu, Holt, Andrew, Schulz, Richard

“…► Calpain and MMP inhibitors have been shown to improve cardiac function in I/R injury. ► PD-150606, ALLN and calpain inhibitor III possess MMP-2 inhibitory…”
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MMP‐2 regulates Src activation via repression of the CHK/MATK tumor suppressor in osteosarcoma by Maybee, Deanna V., Cromwell, Christopher R., Hubbard, Basil P., Ali, Mohammad A. M.

“…Background Doxorubicin, a first‐line anticancer drug for osteosarcoma treatment, has been the subject of recent research exploring the mechanisms behind its…”
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Multifunctional intracellular matrix metalloproteinases: implications in disease by Bassiouni, Wesam, Ali, Mohammad A. M., Schulz, Richard

“…Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases that were first discovered as proteases, which target and cleave extracellular proteins…”
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Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular Milieu by Maybee, Deanna V., Ink, Nicole L., Ali, Mohammad A. M.

“…Matrix metalloproteinases (MMPs) are critical enzymes involved in a variety of cellular processes. MMPs are well known for their ability to degrade the…”
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Editorial commentary: The platelet in COVID-19: A critical participant or a bystander? by Ali, Mohammad A.M.

“…Platelets are the smallest blood cells in the human body, yet an essential component for life. [...]platelets express hundreds of thousands of receptors on…”
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Titin is a Target of Matrix Metalloproteinase-2: Implications in Myocardial Ischemia/Reperfusion Injury by ALI, Mohammad A. M, WOO JUNG CHO, HUDSON, Bryan, KASSIRI, Zamaneh, GRANZIER, Henk, SCHULZ, Richard

“…Titin is the largest mammalian (≈3000 to 4000 kDa) and myofilament protein that acts as a molecular spring in the cardiac sarcomere and determines systolic and…”
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Matrix metalloproteinase‐2 mediates ribosomal RNA transcription by cleaving nucleolar histones by Ali, Mohammad A. M., Garcia‐Vilas, Javier A., Cromwell, Christopher R., Hubbard, Basil P., Hendzel, Michael J., Schulz, Richard

“…Cell proliferation and survival require continuous ribosome biogenesis and protein synthesis. Genes encoding ribosomal RNA are physically located in a…”
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Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix by Kandasamy, Arulmozhi D., Chow, Ava K., Ali, Mohammad A.M., Schulz, Richard

“…Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases which are best known for their ability to proteolyse extracellular matrix…”
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Activation of MMP-2 as a key event in oxidative stress injury to the heart by Ali, Mohammad A M, Schulz, Richard

“…Oxygen and nitrogen derived free radicals play a crucial role in both cardiac physiology and pathology. In this review we discuss how these molecules interact…”
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Matrix metalloproteinase-2 in oncostatin M-induced sarcomere degeneration in cardiomyocytes by Fan, Xiaohu, Hughes, Bryan G, Ali, Mohammad A M, Chan, Brandon Y H, Launier, Katherine, Schulz, Richard

“…Cardiomyocyte dedifferentiation may be an important source of proliferating cardiomyocytes facilitating cardiac repair. Cardiomyocyte dedifferentiation and…”
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Dynamic Alterations to α-Actinin Accompanying Sarcomere Disassembly and Reassembly during Cardiomyocyte Mitosis by Fan, Xiaohu, Hughes, Bryan G, Ali, Mohammad A M, Cho, Woo Jung, Lopez, Waleska, Schulz, Richard

“…Although mammals are thought to lose their capacity to regenerate heart muscle shortly after birth, embryonic and neonatal cardiomyocytes in mammals are…”
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Role of MMP‐2 activation in oncostatin‐M induced cardiomyocyte dedifferentiation by Fan, Frank (Xiaohu), Ali, Mohammad A.M., Hughes, Bryan G., Schulz, Richard

“…Abstract only Despite the dogma that adult mammalian cardiomyocyte is terminally differentiated, these cells have a discrete regenerative capacity in both…”
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Intracellular proteases and sarcomere disassembly in neonatal cardiomyocytes by Fan, Frank (Xiaohu), Ali, Mohammad A.M., Lopez, Waleska, Kondo, Marcia Y., Hughes, Bryan G., Schulz, Richard

“…Abstract only Mammals lose the capacity to regenerate their hearts shortly after birth. Although it is known that neonatal cardiomyocytes need to undergo…”
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Hydrogen peroxide-induced necrotic cell death in cardiomyocytes is independent of matrix metalloproteinase-2 by Ali, Mohammad A.M., Kandasamy, Arulmozhi D., Fan, Xiaohu, Schulz, Richard

“…[Display omitted] •Hydrogen peroxide at 200μM mainly induces necrosis in neonatal rat cardiomyocytes.•Apoptosis only weakly contributes to H2O2 induced…”
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Titin is a Target of MMP-2: Implications in Myocardial Ischemia/Reperfusion Injury by Ali, Mohammad A.M., Cho, Woo Jung, Hudson, Bryan, Kassiri, Zamaneh, Granzier, Henk, Schulz, Richard

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