Search Results - "Ali, Maruf M. U"

UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor by Kopp, Megan C., Larburu, Natacha, Durairaj, Vinoth, Adams, Christopher J., Ali, Maruf M. U.

“…BiP is a major endoplasmic reticulum (ER) chaperone and is suggested to act as primary sensor in the activation of the unfolded protein response (UPR). How BiP…”
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Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex by Pearl, Laurence H, Ali, Maruf M. U, Roe, S. Mark, Vaughan, Cara K, Meyer, Phillipe, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos

“…Hsp90 (heat shock protein of 90 kDa) is a ubiquitous molecular chaperone responsible for the assembly and regulation of many eukaryotic signalling systems and…”
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Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response by Ali, Maruf M U, Bagratuni, Tina, Davenport, Emma L, Nowak, Piotr R, Silva-Santisteban, M Cris, Hardcastle, Anthea, McAndrews, Craig, Rowlands, Martin G, Morgan, Gareth J, Aherne, Wynne, Collins, Ian, Davies, Faith E, Pearl, Laurence H

“…Ire1 (Ern1) is an unusual transmembrane protein kinase essential for the endoplasmic reticulum (ER) unfolded protein response (UPR). Activation of Ire1 by…”
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Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1 by Adams, Christopher J, Kopp, Megan C, Larburu, Natacha, Nowak, Piotr R, Ali, Maruf M U

“…The endoplasmic reticulum (ER) is an important site for protein folding and maturation in eukaryotes. The cellular requirement to synthesize proteins within…”
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Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import by Buchanan, Susan K, Lukacik, Petra, Grizot, Sylvestre, Ghirlando, Rodolfo, Ali, Maruf MU, Barnard, Travis J, Jakes, Karen S, Kienker, Paul K, Esser, Lothar

“…Colicin Ia is a 69 kDa protein that kills susceptible Escherichia coli cells by binding to a specific receptor in the outer membrane, colicin I receptor (70…”
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Chaperone ligand-discrimination by the TPR-domain protein Tah1 by Millson, Stefan H, Vaughan, Cara K, Zhai, Chao, Ali, Maruf M U, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H, Prodromou, Chrisostomos

“…Tah1 [TPR (tetratricopeptide repeat)-containing protein associated with Hsp (heat-shock protein) 90] has been identified as a TPR-domain protein. TPR-domain…”
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UPR Signal Activation by Luminal Sensor Domains by Carrara, Marta, Prischi, Filippo, Ali, Maruf M U

“…The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and…”
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In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress by Kopp, Megan C, Nowak, Piotr R, Larburu, Natacha, Adams, Christopher J, Ali, Maruf Mu

“…The unfolded protein response (UPR) is a key signaling system that regulates protein homeostasis within the endoplasmic reticulum (ER). The primary step in UPR…”
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Structure of an Hsp90-Cdc37-Cdk4 Complex by Vaughan, Cara K., Gohlke, Ulrich, Sobott, Frank, Good, Valerie M., Ali, Maruf M.U., Prodromou, Chrisostomos, Robinson, Carol V., Saibil, Helen R., Pearl, Laurence H.

“…Activation of many protein kinases depends on their interaction with the Hsp90 molecular chaperone system. Recruitment of protein kinase clients to the Hsp90…”
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Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones by Ben-Khoud, Yassin, Chen, Chao-Sheng, Ali, Maruf M U

“…Hsp70 molecular chaperones are essential components for maintaining protein homeostasis within cells. They interact with substrate or client proteins in a well…”
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Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response by Larburu, Natacha, Adams, Christopher J, Chen, Chao-Sheng, Nowak, Piotr R, Ali, Maruf M U

“…Hsp70 chaperones interact with substrate proteins in a coordinated fashion that is regulated by nucleotides and enhanced by assisting cochaperones. There are…”
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Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance by Cerezo, Michaël, Lehraiki, Abdelali, Millet, Antoine, Rouaud, Florian, Plaisant, Magali, Jaune, Emilie, Botton, Thomas, Ronco, Cyril, Abbe, Patricia, Amdouni, Hella, Passeron, Thierry, Hofman, Veronique, Mograbi, Baharia, Dabert-Gay, Anne-Sophie, Debayle, Delphine, Alcor, Damien, Rabhi, Nabil, Annicotte, Jean-Sébastien, Héliot, Laurent, Gonzalez-Pisfil, Mariano, Robert, Caroline, Moréra, Solange, Vigouroux, Armelle, Gual, Philippe, Ali, Maruf M.U., Bertolotto, Corine, Hofman, Paul, Ballotti, Robert, Benhida, Rachid, Rocchi, Stéphane

“…We have discovered and developed a series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous…”
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Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α by Sepulveda, Denisse, Rojas-Rivera, Diego, Rodríguez, Diego A., Groenendyk, Jody, Köhler, Andres, Lebeaupin, Cynthia, Ito, Shinya, Urra, Hery, Carreras-Sureda, Amado, Hazari, Younis, Vasseur-Cognet, Mireille, Ali, Maruf M.U., Chevet, Eric, Campos, Gisela, Godoy, Patricio, Vaisar, Tomas, Bailly-Maitre, Béatrice, Nagata, Kazuhiro, Michalak, Marek, Sierralta, Jimena, Hetz, Claudio

“…Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling network known as the unfolded protein response (UPR). IRE1α is a…”
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Phosphoregulation of Ire1 RNase splicing activity by Prischi, Filippo, Nowak, Piotr R., Carrara, Marta, Ali, Maruf M. U.

“…Ire1 is activated in response to accumulation of misfolded proteins within the endoplasmic reticulum as part of the unfolded protein response (UPR). It is a…”
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Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance by Cerezo, Michaël, Lehraiki, Abdelali, Millet, Antoine, Rouaud, Florian, Plaisant, Magali, Jaune, Emilie, Botton, Thomas, Ronco, Cyril, Abbe, Patricia, Amdouni, Hella, Passeron, Thierry, Hofman, Veronique, Mograbi, Baharia, Dabert-Gay, Anne-Sophie, Debayle, Delphine, Alcor, Damien, Rabhi, Nabil, Annicotte, Jean-Sébastien, Héliot, Laurent, Gonzalez-Pisfil, Mariano, Robert, Caroline, Moréra, Solange, Vigouroux, Armelle, Gual, Philippe, Ali, Maruf M.U., Bertolotto, Corine, Hofman, Paul, Ballotti, Robert, Benhida, Rachid, Rocchi, Stéphane

“…Hepatitis B virus (HBV) is a small DNA virus that replicates by reverse transcription of a terminally redundant RNA, the pregenome. Specific packaging of this…”
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Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling by Carrara, Marta, Prischi, Filippo, Nowak, Piotr R, Ali, Maruf MU

“…Stress caused by accumulation of misfolded proteins within the endoplasmic reticulum (ER) elicits a cellular unfolded protein response (UPR) aimed at…”
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Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer by Chrysostomou, Stelios, Roy, Rajat, Prischi, Filippo, Thamlikitkul, Lucksamon, Chapman, Kathryn L, Mufti, Uwais, Peach, Robert, Ding, Laifeng, Hancock, David, Moore, Christopher, Molina-Arcas, Miriam, Mauri, Francesco, Pinato, David J, Abrahams, Joel M, Ottaviani, Silvia, Castellano, Leandro, Giamas, Georgios, Pascoe, Jennifer, Moonamale, Devmini, Pirrie, Sarah, Gaunt, Claire, Billingham, Lucinda, Steven, Neil M, Cullen, Michael, Hrouda, David, Winkler, Mathias, Post, John, Cohen, Philip, Salpeter, Seth J, Bar, Vered, Zundelevich, Adi, Golan, Shay, Leibovici, Dan, Lara, Romain, Klug, David R, Yaliraki, Sophia N, Barahona, Mauricio, Wang, Yulan, Downward, Julian, Skehel, J Mark, Ali, Maruf M U, Seckl, Michael J, Pardo, Olivier E

“…Lung and bladder cancers are mostly incurable because of the early development of drug resistance and metastatic dissemination. Hence, improved therapies that…”
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Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling by Carrara, Marta, Prischi, Filippo, Nowak, Piotr R, Kopp, Megan C, Ali, Maruf Mu

“…The unfolded protein response (UPR) is an essential cell signaling system that detects the accumulation of misfolded proteins within the endoplasmic reticulum…”
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The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37) by Roe, S Mark, Ali, Maruf M U, Meyer, Philippe, Vaughan, Cara K, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos, Pearl, Laurence H

“…Recruitment of protein kinase clients to the Hsp90 chaperone involves the cochaperone p50(cdc37) acting as a scaffold, binding protein kinases via its…”
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Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response: Structure of the Ire1 autophosphorylation complex and implications for the UPR by Ali, Maruf M U, Bagratuni, Tina, Davenport, Emma L, Nowak, Piotr R, Silva-Santisteban, M Cris, Hardcastle, Anthea, McAndrews, Craig, Rowlands, Martin G, Morgan, Gareth J, Aherne, Wynne, Collins, Ian, Davies, Faith E, Pearl, Laurence H

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