Correlation between depression scores and serum NF-ĸB/NLRP3 axis, biotinidase, and HMGB1 after treatment with isotretinoin in patients with acne vulgaris

Acne vulgaris (AV) is an inflammatory skin disorder leading to scars and discomfort, its intensity has major psychological consequences such as depression. To investigate the effect of isotretinoin (ISO) on NF-κB/NLRP3, biotinidase, and HMGB and correlation with depression. This was a case-control s...

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Bibliographic Details
Published in:	Journal of cosmetic dermatology Vol. 23; no. 10; pp. 3409 - 3417
Main Authors:	Binsaleh, Ammena Y, Ali, Lahin Saad, Bahaa, Mostafa M, Elmasry, Thanaa A, Negm, Walaa A, Hamouda, Amir O, Salahuddin, Muhammed M, Wahsh, Eman, El-Samongy, Marwa Ahmed, Alsubaie, Nawal, El-Khateeb, Eman, Yasser, Mohamed, Eltantawy, Nashwa
Format:	Journal Article
Language:	English
Published:	England 01-10-2024
Subjects:	Acne Vulgaris - blood Acne Vulgaris - drug therapy Acne Vulgaris - psychology Adolescent Adult Biomarkers - blood Biotinidase - blood Case-Control Studies Depression - blood Depression - diagnosis Depression - drug therapy Depression - etiology Dermatologic Agents - administration & dosage Dermatologic Agents - adverse effects Dermatologic Agents - therapeutic use Female HMGB1 Protein - blood Humans Isotretinoin - administration & dosage Isotretinoin - adverse effects Isotretinoin - therapeutic use Male NF-kappa B - blood NF-kappa B - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - blood NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Severity of Illness Index Young Adult acne vulgaris NLRP3 HMGB1 depression biotinidase
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Summary:	Acne vulgaris (AV) is an inflammatory skin disorder leading to scars and discomfort, its intensity has major psychological consequences such as depression. To investigate the effect of isotretinoin (ISO) on NF-κB/NLRP3, biotinidase, and HMGB and correlation with depression. This was a case-control study that involved two groups. Group 1 is 20 healthy control, and group 2 is 20 patients diagnosed with AV according to Global Acne Grading System (GAGS) and received 20 mg ISO for 2 months. Before and after therapy, the Hamilton Depression Rating Scale (HDRS) was applied to assess each participant's level of depression. Nuclear factor kappa B (NF-ĸB), biotinidase, high mobility group box protein (HMGB1), nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (NLRP-3) were measured in serum samples. There was no significant difference in all measured markers of healthy group before and after 2 months. Regarding group 2, there was a statistically significant decrease in all measured markers after 2 months of treatment and significant correlations between GAGS, NF-ĸB, HMGB1, NLRP3, biotinidase, and depression score. Increased GAGS, HMGB1, NLRP3, and biotinidase were associated with depression severity in AV patients and ISO treatment significantly reduced these parameters and reduced depressive symptoms.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1473-2130 1473-2165 1473-2165
DOI:	10.1111/jocd.16433