Search Results - "Ali, Hamed I"

Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies by Samaha, Doaa, Mahmoud, Sawsan, Mohamed, Mosaad Sayed, Abdullah, Rokaia S, A Abou Taleb, Nageh, Nagamatsu, Tomohisa, Ali, Hamed I

“…This study describes the development of novel alloxazine analogues as potent antitumor agents with enhanced selectivity for tumour cells. Twenty-nine out of 45…”
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Targeting CDC7 sensitizes resistance melanoma cells to BRAFV600E-specific inhibitor by blocking the CDC7/MCM2-7 pathway by Gad, Shaimaa A., Ali, Hamdy E. A., Gaballa, Rofaida, Abdelsalam, Rania M., Zerfaoui, Mourad, Ali, Hamed I., Salama, Salwa H., Kenawy, Sanaa A., Kandil, Emad, Abd Elmageed, Zakaria Y.

“…Although the utilization of selective BRAF V600E inhibitors is associated with improved overall survival in patients with metastatic melanoma, a growing…”
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Exosomes-Mediated Transfer of Itga2 Promotes Migration and Invasion of Prostate Cancer Cells by Inducing Epithelial-Mesenchymal Transition by Gaballa, Rofaida, Ali, Hamdy E. A., Mahmoud, Mohamed O., Rhim, Johng S., Ali, Hamed I., Salem, Heba F., Saleem, Mohammad, Kandeil, Mohamed A., Ambs, Stefan, Abd Elmageed, Zakaria Y.

“…Although integrin alpha 2 subunit (ITGA2) mediates cancer progression and metastasis, its transfer by exosomes has not been investigated in prostate cancer…”
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Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids by Hegazy, Gehan H., Ali, Hamed I.

“…The ibuprofenic acid and mefenamic acid esters coupled with [4-(4-substituted benzylidene amino)phenols] Schiff’s bases revealed remarkable analgesic…”
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Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studies by Bedewy, Walaa A., Mohamed, Mosaad S., Abdelhameed, Ahmed M., Elsawy, Mohamed A., Al-Muhur, Mohammed, Ashida, Noriyuki, Abdalla, Ashraf N, Elwaie, Tamer A., Nagamatsu, Tomohisa, Ali, Hamed I.

“…Novel 5-deazaflavins were designed as potential anticancer candidates. Compounds 4j, 4k, 5b, 5i, and 9f demonstrated high cytotoxicity against MCF-7 cell line…”
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LY2087101 and dFBr share transmembrane binding sites in the (α4)3(β2)2 Nicotinic Acetylcholine Receptor by Deba, Farah, Ali, Hamed I., Tairu, Abisola, Ramos, Kara, Ali, Jihad, Hamouda, Ayman K.

“…Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have potential therapeutic application in neuropathologies associated with…”
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Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1) by Khurana, Leepakshi, Ali, Hamed I, Olszewska, Teresa, Ahn, Kwang H, Damaraju, Aparna, Kendall, Debra A, Lu, Dai

“…5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)­phenethyl)-1H-indole-2-carboxamide (1; ORG27569) is a prototypical allosteric modulator for the cannabinoid type 1…”
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Exosomes are the Driving Force in Preparing the Soil for the Metastatic Seeds: Lessons from the Prostate Cancer by Saber, Saber H, Ali, Hamdy E A, Gaballa, Rofaida, Gaballah, Mohamed, Ali, Hamed I, Zerfaoui, Mourad, Abd Elmageed, Zakaria Y

“…Exosomes are nano-membrane vesicles that various cell types secrete during physiological and pathophysiological conditions. By shuttling bioactive molecules…”
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Design, Synthesis, Antitumor Activity and Molecular Docking Study of Novel 5-Deazaalloxazine Analogs by Mahmoud, Sawsan, Samaha, Doaa, Mohamed, Mosaad S, Abou Taleb, Nageh A, Elsawy, Mohamed A, Nagamatsu, Tomohisa, Ali, Hamed I

“…Protein tyrosine kinases (PTKs) are the most potential therapeutic targets for cancer. Herein, we present a sound rationale for synthesis of a series of novel…”
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Design, Synthesis, and Biological Evaluation of Some Novel Pyrrolizine Derivatives as COX Inhibitors with Anti-Inflammatory/Analgesic Activities and Low Ulcerogenic Liability by Gouda, Ahmed M, Ali, Hamed I, Almalki, Waleed H, Azim, Mohamed A, Abourehab, Mohammed A S, Abdelazeem, Ahmed H

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed anti-inflammatory and pain relief medications. However, their use is associated…”
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Dual Targeting of VEGFR2 and C‑Met Kinases via the Design and Synthesis of Substituted 3‑(Triazolo-thiadiazin-3-yl)indolin-2-one Derivatives as Angiogenesis Inhibitors by Mohamady, Samy, Galal, Mahmoud, Eldehna, Wagdy M, Gutierrez, David C, Ibrahim, Hany S, Elmazar, Mohey M, Ali, Hamed I

“…The vascular endothelial growth factor receptor 2 (VEGFR2) and c-mesenchymal epithelial transition factor (c-Met) are members of receptor tyrosine kinases…”
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Synthesis, docking and biological activities of novel hybrids celecoxib and anthraquinone analogs as potent cytotoxic agents by Almutairi, Maha S, Hegazy, Gehan H, Haiba, Mogedda E, Ali, Hamed I, Khalifa, Nagy M, Soliman, Abd El-mohsen M

“…Herein, novel hybrid compounds of celecoxib and 2-aminoanthraquinone derivatives have been synthesized using condensation reactions of celecoxib with…”
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Metal‐ and Catalyst‐Free Synthesis of 2‐Substituted‐Phthalimides Using 2‐(Arenesulfonyl)Phthalimide as Key Reagents by Khalifa, Abdalrahman, Giles, Marco, Ali, Hamed I., Mohamady, Samy

“…Phthalimide derivatives are important in medicinal chemistry, several phthalimidation methodologies have been developed. Here, we report a facile, metal‐free,…”
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Antitumor studies. Part 1: Design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents by Ali, Hamed I., Tomita, Keiichiro, Akaho, Eiichi, Kambara, Hiroto, Miura, Shinji, Hayakawa, Hiroyuki, Ashida, Noriyuki, Kawashima, Yutaka, Yamagishi, Takehiro, Ikeya, Hisao, Yoneda, Fumio, Nagamatsu, Tomohisa

“…The prepared 2-deoxo-2-phenyl-5-deazaflavins ( 1) and 2-deoxo-2-phenylflavin-5-oxides ( 2) exhibited significant antitumor activities against CCRF-HSB-2, KB,…”
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In-use stability assessment of FDA approved metformin immediate release and extended release products for N-Nitrosodimethylamine and dissolution quality attributes by Dharani, Sathish, Mohamed, Eman M., Khuroo, Tahir, Ali, Hamed I., Reddy, Indra K., Rahman, Ziyaur, Khan, Mansoor A.

“…[Display omitted] Metformin is a widely used first-line oral antidiabetic agent. TheFood and Drug Administration (FDA) confirmed the presence of the…”
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HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability by Elwaie, Tamer A, Abbas, Safinaz E, Aly, Enayat I, George, Riham F, Ali, Hamdy, Kraiouchkine, Nikolai, Abdelwahed, Khaldoun S, Fandy, Tamer E, El Sayed, Khalid A, Abd Elmageed, Zakaria Y, Ali, Hamed I

“…HER2 kinase as a well-established target for breast cancer (BC) therapy is associated with aggressive clinical outcomes; thus, herein we present structural…”
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The plasticizer BBP selectively inhibits epigenetic regulator sirtuins by Zhang, Jian, Ali, Hamed I, Bedi, Yudhishtar Singh, Choudhury, Mahua

“…Highlights • In silico molecular docking studies showed that the plasticizer benzyl butyl phthalate (BBP) can bind to sirtuins. • BBP decreased only Sirt1 and…”
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Synthesis and molecular docking study of new benzofuran and furo[3,2-g]chromone-based cytotoxic agents against breast cancer and p38α MAP kinase inhibitors by Amin, Kamelia M., Syam, Yasmin M., Anwar, Manal M., Ali, Hamed I., Abdel-Ghani, Tamer M., Serry, Aya M.

“…[Display omitted] •A new set of benzofuran and 5H-furo[3,2-g]chromone linked various heterocyclic functionalities was synthesized.•In vitro cytotoxic…”
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Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities by Kassab, Shaymaa E., Khedr, Mohammed A., Ali, Hamed I., Abdalla, Mohamed M.

“…New ring-extended analogs of indomethacin were designed based on the structure of active binding site of both COX-1 and COX-2 isoenzymes and the interaction…”
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Synthesis, antitumor activity and molecular docking study of novel sulfonamide-Schiff's bases, thiazolidinones, benzothiazinones and their C-nucleoside derivatives by Kamel, Mohsen M, Ali, Hamed I, Anwar, Manal M, Mohamed, Neama A, Soliman, Abdelmohsen M

“…A series of sulfapyridine-polyhydroxyalkylidene (or arylidene)-imino derivatives (Schiff's bases) 2a-c and 4a-e were prepared by condensation of…”
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