Search Results - "Ali, Bassam"

Endoglin mutants retained in the endoplasmic reticulum exacerbate loss of function in hereditary hemorrhagic telangiectasia type 1 (HHT1) by exerting dominant negative effects on the wild type allele by Gariballa, Nesrin, Badawi, Sally, Ali, Bassam R.

“…Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder affecting 1 in 5000–8000 individuals. Hereditary hemorrhagic telangiectasia type…”
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ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues by Badawi, Sally, Ali, Bassam R

“…With the emergence of the novel coronavirus SARS-CoV-2 since December 2019, more than 65 million cases have been reported worldwide. This virus has shown high…”
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Insights into the charge transfer kinetics in BiVO4 photoanodes modified with transition metal-based oxygen evolution electrocatalysts by Jahangir, Tahir Naveed, Khan, Abdul Zeeshan, Kandiel, Tarek A., El Ali, Bassam M.

“…BiVO4 is a promising photoanode for photoelectrochemical (PEC) water splitting. Nevertheless, the sluggish water oxidation on its surface causes severe charge…”
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Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study by Dasari, Arvind, Lonardi, Sara, Garcia-Carbonero, Rocio, Elez, Elena, Yoshino, Takayuki, Sobrero, Alberto, Yao, James, García-Alfonso, Pilar, Kocsis, Judit, Cubillo Gracian, Antonio, Sartore-Bianchi, Andrea, Satoh, Taroh, Randrian, Violaine, Tomasek, Jiri, Chong, Geoff, Paulson, Andrew Scott, Masuishi, Toshiki, Jones, Jeremy, Csőszi, Tibor, Cremolini, Chiara, Ghiringhelli, Francois, Shergill, Ardaman, Hochster, Howard S, Krauss, John, Bassam, Ali, Ducreux, Michel, Elme, Anneli, Faugeras, Laurence, Kasper, Stefan, Van Cutsem, Eric, Arnold, Dirk, Nanda, Shivani, Yang, Zhao, Schelman, William R, Kania, Marek, Tabernero, Josep, Eng, Cathy

“…There is a paucity of effective systemic therapy options for patients with advanced, chemotherapy-refractory colorectal cancer. We aimed to evaluate the…”
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Classification of Dysarthric Speech According to the Severity of Impairment: an Analysis of Acoustic Features by Al-Qatab, Bassam Ali, Mustafa, Mumtaz Begum

“…The automatic speech recognition (ASR) system is increasingly being applied as assistive technology in the speech impaired community, for individuals with…”
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Pathological Crosstalk Between Oxidized LDL and ER Stress in Human Diseases: A Comprehensive Review by Varghese, Divya Saro, Ali, Bassam R.

“…The oxidative modification of the major cholesterol carrying lipoprotein, oxLDL, is a biomarker as well as a pathological factor in cardiovascular diseases…”
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The double whammy of ER-retention and dominant-negative effects in numerous autosomal dominant diseases: significance in disease mechanisms and therapy by Gariballa, Nesrin, Mohamed, Feda, Badawi, Sally, Ali, Bassam R

“…The endoplasmic reticulum (ER) employs stringent quality control mechanisms to ensure the integrity of protein folding, allowing only properly folded,…”
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Stereoelectronic Flexibility of Ammonium-Functionalized Triazole-Derived Carbenes: Palladation and Catalytic Activities in Water by Nguyen, Van Ha, El Ali, Bassam M, Huynh, Han Vinh

“…The postmodification approach allows convenient access to charge-tagged ammonium-functionalized bis­(1,2,4-triazolin-5-ylidene)­palladium­(II) complexes even…”
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Genetic disruption of mammalian endoplasmic reticulum‐associated protein degradation: Human phenotypes and animal and cellular disease models by Badawi, Sally, Mohamed, Feda E., Varghese, Divya Saro, Ali, Bassam R.

“…Endoplasmic reticulum‐associated protein degradation (ERAD) is a stringent quality control mechanism through which misfolded, unassembled and some native…”
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Theoretical prediction and electrochemical evaluation of vinylimidazole and allylimidazole as corrosion inhibitors for mild steel in 1 M HCl by Obot, I.B., Umoren, S.A., Gasem, Z.M., Suleiman, Rami, Ali, Bassam El

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Mendelian randomization in pharmacogenomics: The unforeseen potentials by Khasawneh, Lubna Q., Al-Mahayri, Zeina N., Ali, Bassam R.

“…Mendelian randomization (MR) is an epidemiological method that uses genetic variants to proxy an exposure predicting its causal association with an outcome. It…”
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DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer by Sasidharan Nair, Varun, El Salhat, Haytham, Taha, Rowaida Z, John, Anne, Ali, Bassam R, Elkord, Eyad

“…High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor…”
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Modelling parents' unhealthy food choices for their children: the moderating role of child food allergy and implications for health policy by Mahmoud, Ali Bassam, Grigoriou, Nicholas

“…We investigated the effects of parent's gender, education, and attitudes towards childhood obesity on parents' unhealthy food choices for their children and…”
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New Constituents from the Leaves of Date Palm (Phoenix dactylifera L.) of Saudi Origin by Suleiman, Rami K., Iali, Wissam, El Ali, Bassam, Umoren, Saviour A.

“…The phytochemical analysis of the butanolic extract from the leaves of date palm of Saudi origin resulted in the isolation of three major constituents,…”
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Optimization of fatigue life in laminated composite plates by Ahmed, Bassam Ali

“…With the development of fiber technology on which the composite materials depend mainly was necessary to improve the rigidity, durability, and heat transfer in…”
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Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment by Syed Khaja, Azharuddin Sajid, Toor, Salman M, El Salhat, Haytham, Faour, Issam, Ul Haq, Navid, Ali, Bassam R, Elkord, Eyad

“…Immunosuppressive cells such as regulatory T cells (Tregs) have an ambiguous role in breast cancer prognosis, with studies reporting both positive and negative…”
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The Evaluation of Drugs as Potential Modulators of the Trafficking and Maturation of ACE2, the SARS-CoV-2 Receptor by Alkhofash, Nesreen F, Ali, Bassam R

“…ACE2, part of the angiotensin-converting enzyme family and the renin-angiotensin-aldosterone system (RAAS), plays vital roles in cardiovascular and renal…”
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A review of genetic variant databases and machine learning tools for predicting the pathogenicity of breast cancer by Ahmad, Rahaf M, Ali, Bassam R, Al-Jasmi, Fatma, Sinnott, Richard O, Al Dhaheri, Noura, Mohamad, Mohd Saberi

“…Studies continue to uncover contributing risk factors for breast cancer (BC) development including genetic variants. Advances in machine learning and big data…”
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GRP78/BiP alleviates oxLDL-induced hepatotoxicity in familial hypercholesterolemia caused by missense variants of LDLR in a HepG2 cellular model by Varghese, Divya Saro, Oommen, Deepu, John, Anne, Ali, Bassam R

“…The accumulation of misfolded proteins, encoded by genetic variants of functional genes leads to Endoplasmic Reticulum (ER) stress, which is a critical…”
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Disorders of FZ-CRD; insights towards FZ-CRD folding and therapeutic landscape by Milhem, Reham M, Ali, Bassam R

“…The ER is hub for protein folding. Proteins that harbor a Frizzled cysteine-rich domain (FZ-CRD) possess 10 conserved cysteine motifs held by a unique…”
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