Search Results - "Alhonen, Leena"

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity by Kraus, Daniel, Yang, Qin, Kong, Dong, Banks, Alexander S., Zhang, Lin, Rodgers, Joseph T., Pirinen, Eija, Pulinilkunnil, Thomas C., Gong, Fengying, Wang, Ya-chin, Cen, Yana, Sauve, Anthony A., Asara, John M., Peroni, Odile D., Monia, Brett P., Bhanot, Sanjay, Alhonen, Leena, Puigserver, Pere, Kahn, Barbara B.

“…Nicotinamide N -methyltransferase (NNMT) expression is increased in white adipose tissue and liver of obese and diabetic mice, Nnmt knockdown protects against…”
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Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes by Van den Bossche, Jan, Lamers, Wouter H., Koehler, Eleonore S., Geuns, Jan M. C., Alhonen, Leena, Uimari, Anne, Pirnes‐Karhu, Sini, Van Overmeire, Eva, Morias, Yannick, Brys, Lea, Vereecke, Lars, De Baetselier, Patrick, Van Ginderachter, Jo A.

“…While polyamines contribute to IL‐4‐induced expression of several alternatively activated macrophage markers, they inhibit the LPS‐mediated expression of…”
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Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation by BRY, Maija, KIVELÄ, Riikka, CARMELIET, Peter, LEMSTRÖM, Karl B, SHIBUYA, Masabumi, YLÄ-HERTTUALA, Seppo, ALHONEN, Leena, MERVAALA, Eero, ANDERSSON, Leif C, KNUUTI, Juhani, ALITALO, Kari, HOLOPAINEN, Tanja, ANISIMOV, Andrey, TAMMELA, Tuomas, SORONEN, Jarkko, SILVOLA, Johanna, SARASTE, Antti, JELTSCH, Michael, KORPISALO, Petra

“…Vascular endothelial growth factor-B (VEGF-B) binds to VEGF receptor-1 and neuropilin-1 and is abundantly expressed in the heart, skeletal muscle, and brown…”
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Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions by Hyvönen, Mervi T, Smirnova, Olga A, Mitkevich, Vladimir A, Tunitskaya, Vera L, Khomutov, Maxim, Karpov, Dmitry S, Korolev, Sergey P, Häkkinen, Merja R, Pietilä, Marko, Gottikh, Marina B, Vepsäläinen, Jouko, Alhonen, Leena, Makarov, Alexander A, Kochetkov, Sergey N, Wallace, Heather M, Keinänen, Tuomo A, Khomutov, Alex R

“…The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key…”
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Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells by Smirnova, Olga A., Isaguliants, Maria G., Hyvonen, Mervi T., Keinanen, Tuomo A., Tunitskaya, Vera L., Vepsalainen, Jouko, Alhonen, Leena, Kochetkov, Sergey N., Ivanov, Alexander V.

“…Biogenic polyamines spermine and spermidine participate in numerous cellular processes including transcription, RNA processing and translation. Specifically,…”
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Enhanced Polyamine Catabolism Alters Homeostatic Control of White Adipose Tissue Mass, Energy Expenditure, and Glucose Metabolism by Pirinen, Eija, Kuulasmaa, Teemu, Pietilä, Marko, Heikkinen, Sami, Tusa, Maija, Itkonen, Paula, Boman, Susanna, Skommer, Joanna, Virkamäki, Antti, Hohtola, Esa, Kettunen, Mikko, Fatrai, Szabolcs, Kansanen, Emilia, Koota, Suvi, Niiranen, Kirsi, Parkkinen, Jyrki, Levonen, Anna-Liisa, Ylä-Herttuala, Seppo, Hiltunen, J. Kalervo, Alhonen, Leena, Smith, Ulf, Jänne, Juhani, Laakso, Markku

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Polyamines and hair: a couple in search of perfection by Ramot, Yuval, Pietilä, Marko, Giuliani, Giammaria, Rinaldi, Fabio, Alhonen, Leena, Paus, Ralf

“…Please cite this paper as: Polyamines and hair: a couple in search of perfection. Experimental Dermatology 2010; 19: 784–790. :  Polyamines (spermidine,…”
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Activation of Polyamine Catabolism by N1,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype by Ivanova, Olga N., Snezhkina, Anastasiya V., Krasnov, George S., Valuev-Elliston, Vladimir T., Khomich, Olga A., Khomutov, Alexey R., Keinanen, Tuomo A., Alhonen, Leena, Bartosch, Birke, Kudryavtseva, Anna V., Kochetkov, Sergey N., Ivanov, Alexander V.

“…Tumorigenesis is accompanied by the metabolic adaptation of cells to support enhanced proliferation rates and to optimize tumor persistence and amplification…”
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Charge deficient analogues of the natural polyamines by Weisell, Janne, Hyvönen, Mervi T, Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A, Khomutov, Alex R

“…Mitochondrial dysfunction, either inherited or acquired, is associated with several diseases in humans. Depending on the cell type and location, cells are…”
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Spermidine is indispensable in differentiation of 3T3‐L1 fibroblasts to adipocytes by Vuohelainen, Susanna, Pirinen, Eija, Cerrada‐Gimenez, Marc, Keinänen, Tuomo A., Uimari, Anne, Pietilä, Marko, Khomutov, Alex R., Jänne, Juhani, Alhonen, Leena

“…Impaired adipogenesis has been shown to predispose to disturbed adipocyte function and development of metabolic abnormalities. Previous studies indicate that…”
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Role of Hypusinated Eukaryotic Translation Initiation Factor 5A in Polyamine Depletion-induced Cytostasis by Hyvönen, Mervi T., Keinänen, Tuomo A., Cerrada-Gimenez, Marc, Sinervirta, Riitta, Grigorenko, Nikolay, Khomutov, Alex R., Vepsäläinen, Jouko, Alhonen, Leena, Jänne, Juhani

“…We have earlier shown that α-methylated spermidine and spermine analogues rescue cells from polyamine depletion-induced growth inhibition and maintain…”
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The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis by Koponen, Taina, Cerrada-Gimenez, Marc, Pirinen, Eija, Hohtola, Esa, Paananen, Jussi, Vuohelainen, Susanna, Tusa, Maija, Pirnes-Karhu, Sini, Heikkinen, Sami, Virkamäki, Antti, Uimari, Anne, Alhonen, Leena, Laakso, Markku

“…The mitochondrial biogenesis and energy expenditure regulator, PGC-1α, has been previously reported to be induced in the white adipose tissue (WAT) and liver…”
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Genetic approaches to the cellular functions of polyamines in mammals by Jänne, Juhani, Alhonen, Leena, Pietilä, Marko, Keinänen, Tuomo A.

“…The polyamines putrescine, spermidine and spermine are organic cations shown to participate in a bewildering number of cellular reactions, yet their exact…”
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Assay of Ornithine Decarboxylase and Spermidine/Spermine N1-acetyltransferase Activities by Mervi Hyvönen, Tuomo Keinänen, Leena Alhonen

“…The polyamines, spermidine (Spd) and spermine, and their diamine precursor putrescine, are important regulators of various cellular functions, such as…”
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Genetic Manipulation of Polyamine Catabolism in Rodents by Jänne, Juhani, Alhonen, Leena, Pietilä, Marko, Keinänen, Tuomo A, Uimari, Anne, Hyvönen, Mervi T, Pirinen, Eija, Järvinen, Aki

“…Activation of polyamine catabolism through the overexpression of spermidine/spermine N¹-acetyltransferase (SSAT) in transgenic rodents does not only lead to…”
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Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults by Cerrada-Gimenez, Marc, Pietilä, Marko, Loimas, Suvikki, Pirinen, Eija, Hyvönen, Mervi T, Keinänen, Tuomo A, Jänne, Juhani, Alhonen, Leena

“…Enhanced polyamine catabolism via polyamine acetylation-oxidation elevates the oxidative stress in an organism due to increased production of reactive oxygen…”
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Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis by Pirinen, Eija, Gylling, Helena, Itkonen, Paula, Yaluri, Nagendra, Heikkinen, Sami, Pietilä, Marko, Kuulasmaa, Teemu, Tusa, Maija, Cerrada-Gimenez, Marc, Pihlajamäki, Jussi, Alhonen, Leena, Jänne, Juhani, Miettinen, Tatu A, Laakso, Markku

“…Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N¹-acetyltransferase (SSAT) have significantly reduced plasma…”
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α-Methyl Polyamines:  Efficient Synthesis and Tolerance Studies in Vivo and in Vitro. First Evidence for Dormant Stereospecificity of Polyamine Oxidase by Järvinen, Aki J, Cerrada-Gimenez, Marc, Grigorenko, Nikolay A, Khomutov, Alex R, Vepsäläinen, Jouko J, Sinervirta, Riitta M, Keinänen, Tuomo A, Alhonen, Leena I, Jänne, Juhani E

“…Efficient syntheses of metabolically stable α-methylspermidine 1, α-methylspermine 2, and bis-α,α‘-methylated spermine 3 starting from ethyl 3-aminobutyrate…”
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Activation of Polyamine Catabolism in Transgenic Rats Induces Acute Pancreatitis by Alhonen, Leena, Parkkinen, Jyrki J., Keinanen, Tuomo, Sinervirta, Riitta, Herzig, Karl-Heinz, Janne, Juhani

“…Polyamines are required for optimal growth and function of cells. Regulation of their cellular homeostasis is therefore tightly controlled. The key regulatory…”
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VEGFR-1 and -2 Regulate Inflammation, Myocardial Angiogenesis, and Arteriosclerosis in Chronically Rejecting Cardiac Allografts by Raisky, Olivier, Nykänen, Antti I, Krebs, Rainer, Hollmén, Maria, Keränen, Mikko A.I, Tikkanen, Jussi M, Sihvola, Roope, Alhonen, Leena, Salven, Petri, Wu, Yan, Hicklin, Daniel J, Alitalo, Kari, Koskinen, Petri K, Lemström, Karl B

“…OBJECTIVE—Interplay between inflammation and angiogenesis is important in pathological reparative processes such as arteriosclerosis. We investigated how the…”
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