Search Results - "Alhonen, L."

Altered glucose-stimulated insulin secretion in a mouse line with activated polyamine catabolism by Cerrada-Gimenez, M, Tusa, M, Casellas, A, Pirinen, E, Moya, M, Bosch, F, Alhonen, L

“…Ubiquitous activation of polyamine catabolism has been demonstrated to have protective effects in mice on fat accumulation and insulin sensitivity/glucose…”
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Mechanisms of polyamine catabolism-induced acute pancreatitis by Hyvönen, M T, Merentie, M, Uimari, A, Keinänen, T A, Jänne, J, Alhonen, L

“…Acute pancreatitis is an autodigestive disease, in which the pancreatic tissue is damaged by the digestive enzymes produced by the acinar cells. Among the…”
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Characterization of sleep-wake patterns in a novel transgenic mouse line overexpressing human prepro-orexin/hypocretin by Mäkelä, K.A, Wigren, H.-K, Zant, J.C, Sakurai, T, Alhonen, L, Kostin, A, Porkka-Heiskanen, T, Herzig, K.-H

“…Orexin/hypocretin peptides are expressed in the lateral hypothalamus and involved in the regulation of autonomic functions, energy homeostasis and arousal…”
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Hydroxylamine derivatives for regulation of spermine and spermidine metabolism by Khomutov, M. A., Weisell, J., Hyvönen, M., Keinänen, T. A., Vepsäläinen, J., Alhonen, L., Khomutov, A. R., Kochetkov, S. N.

“…The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are…”
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Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the β-amyloid peptide intracellularly in hippocampal and cortical neurons by Echeverria, V., Ducatenzeiler, A., Dowd, E., Jänne, J., Grant, S.M., Szyf, M., Wandosell, F., Avila, J., Grimm, H., Dunnett, S.B., Hartmann, T., Alhonen, L., Cuello, A.C.

“…The pathological significance of intracellular Aβ accumulation in vivo is not yet fully understood. To address this, we have studied transgenic rats expressing…”
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Stable analogues of coenzyme-substrate complex of spermidine/spermine-N1-acetyltransferase reaction. synthesis, interaction with the enzyme by Keĭnanen, T A, Khivonen, T, Vepsalajnen, Ĭ, Alhonen, L, Homutov, A R, Ianne, Iu

“…Convenient two-step synthesis of conjugates of HS-CoA and D-pantetheine with aminooxy analogues of Spm, Spd and Put was suggested. The use of acetone linker…”
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Effect of medium- and long-chain fatty acid diets on PPAR and SREBP-1 expression and glucose homeostasis in ACBP-overexpressing transgenic rats by Oikari, S, Ahtialansaari, T, Huotari, A, Kiehne, K, Fölsch, U.R, Wolffram, S, Jänne, J, Alhonen, L, Herzig, K.-H

“…Acyl-CoAs are important intermediates and regulators of lipid metabolism. Binding proteins like acyl-CoA binding protein (ACBP) can influence their regulatory…”
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Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis by Merentie, M, Uimari, A, Pietilä, M, Sinervirta, R, Keinänen, T. A, Vepsäläinen, J, Khomutov, A, Grigorenko, N, Herzig, K.-H, Jänne, J, Alhonen, L

“…The markers of oxidative stress and inflammation were studied in acute pancreatitis in transgenic rats exhibiting activated polyamine catabolism. In addition,…”
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Effects of mobile phone radiation on UV-induced skin tumourigenesis in ornithine decarboxylase transgenic and non-transgenic mice by HEIKKINEN, P., KOSMA, V.-M., ALHONEN, L., HUUSKONEN, H., KOMULAINEN, H., KUMLIN, T., LAITINEN, J. T., LANG, S., PURANEN, L., JUUTILAINEN, J.

“…Purpose: The effects of low-level radiofrequency radiation (RFR) on ultraviolet (UV)-induced skin tumorigenesis were evaluated in ornithine decarboxylase (ODC)…”
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Acute Pancreatitis Induced by Activated Polyamine Catabolism Is Associated with Coagulopathy: Effects of α-Methylated Polyamine Analogs on Hemostasis by Hyvönen, M.T, Sinervirta, R, Keinänen, T.A, Fashe, T, Grigorenko, N, Khomutov, A.R, Vepsäläinen, J, Alhonen, L

“…Abstract Background/Aims: Polyamines are ubiquitous organic cations essential for cellular proliferation and tissue integrity. We have previously shown that…”
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Endothelial-specific gene expression directed by the tie gene promoter in vivo by KORHONEN, J, LAHTINEN, I, HALMEKYTÖ, M, ALHONEN, L, JÄNNE, J, DUMONT, D, ALITALO, K

“…The tie gene encodes a receptor tyrosine kinase that is expressed in the endothelium of blood vessels, particularly during embryonic development and…”
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Modest increase in temperature affects ODC activity in L929 cells: Low-level radiofrequency radiation does not by Höytö, A, Sihvonen, A-P, Alhonen, L, Juutilainen, J, Naarala, J

“…The effects of low-level radiofrequency (RF) radiation and elevated temperature on ornithine decarboxylase (ODC) activity were investigated in murine L929…”
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Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice by Suppola, S, Heikkinen, S, Parkkinen, J J, Uusi-Oukari, M, Korhonen, V P, Keinänen, T, Alhonen, L, Jänne, J

“…We have generated a hybrid transgenic mouse line overexpressing both ornithine decarboxylase (ODC) and spermidine/spermine N(1)-acetyltransferase (SSAT) under…”
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Genomic hypomethylation in human chronic lymphocytic leukemia by WAHLFORS, J, HILTUNEN, H, HEINONEN, K, HÄMÄLÄINEN, E, ALHONEN, L, JÄNNE, J

“…DNA samples from patients with chronic lymphocytic (CLL), chronic myelocytic (CML), acute myelocytic (AML), and acute lymphocytic leukemia (ALL), as well as…”
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Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and enzymes of their metabolism by Khomutov, A. R, Keinanen, T. A, Grigorenko, N. A, Hyvonen, M. T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A. R, Khomutov, M. A, Vepsalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine (Spm) and spermidine (Spd) are essential for cell growth. Polyamine analogs are widely used to investigate the enzymes of polyamine…”
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Effects of 50 Hz magnetic fields on UV-induced skin tumourigenesis in ODC-transgenic and non-transgenic mice by KUMLIN, T., KOSMA, V.-M., ALHONEN, L, JANNE, J, KOMULAINEN, H, LANG, S, RYTOMAA, T, SERVOMAA, K, JUUTILAINEN, J

“…Purpose: To study the possible role of 50 Hz magnetic fields (MF) in UV-induced skin tumourigenesis using a sensitive animal model. Materials and methods:…”
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Gossypol Activates Pancreatic Polyamine Catabolism in Normal Rats and Induces Acute Pancreatitis in Transgenic Rats Over-expressing Spermidine/Spermine N 1 -Acetyltransferase by T.-L., Räsänen, L., Alhonen, R., Sinervirta, A., Uimari, K., Kaasinen, T., Keinänen, K.-H., Herzig, J., Jänne

“…Background: The male antifertility agent gossypol has been reported to induce spermidine/spermine N 1 -acetyltransferase (SSAT) in canine prostate cells. As…”
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Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism by Khomutov, A R, Keinanen, T A, Grigorenko, N A, Hyvonen, M T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A R, Khomutov, M A, Verspalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine and spermidine are essential factors of cellular growth. Polyamine analogues are widely used to investigate and to regulate the…”
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Transgenic mice aberrantly expressing human ornithine decarboxylase gene by HALMEKYTO, M, HYTTINEN, J.-M, JANNE, J, SINERVIRTA, R, UTRIAINEN, M, MYOHANEN, S, VOIPIO, H.-M, WAHLFORS, J, SYRJANEN, S, SYRJANEN, K, ALHONEN, L

“…We have generated transgenic mice carrying human ornithine decarboxylase gene. Two different transgene constructs were used: (i) a 5'-truncated human ornithine…”
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New syntheses of α-methyl- and α,α′-dimethylspermine by Grigorenko, N. A., Vepsalainen, J., Jarvinen, A., Keinanen, T. A., Alhonen, L., Janne, J., Khomutov, A. R.

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