Search Results - "Alhassan, Hassan H"
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Advanced vaccinomic, immunoinformatic, and molecular modeling strategies for designing Multi- epitope vaccines against the Enterobacter cloacae complex
Published in Frontiers in immunology (2024)“…The increasing and ongoing issue of antibiotic resistance in bacteria is of huge concern globally, mainly to healthcare facilities. It is now crucial to…”
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Structure-Guided Approach to Discover Tuberosin as a Potent Activator of Pyruvate Kinase M2, Targeting Cancer Therapy
Published in International journal of molecular sciences (01-11-2022)“…Metabolic reprogramming is a key attribute of cancer progression. An altered expression of pyruvate kinase M2 (PKM2), a phosphotyrosine-binding protein is…”
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Exploring glutathione transferase and Cathepsin L-like proteinase for designing of epitopes-based vaccine against Fasciola hepatica by immunoinformatics and biophysics studies
Published in Frontiers in immunology (26-09-2024)“…Fasciolosis is a zoonotic infection and is considered a developing deserted tropical illness threatening ruminant productivity and causing financial losses…”
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Evaluation of time to sputum smear conversion and its association with treatment outcomes among drug-resistant tuberculosis patients: a retrospective record-reviewing study
Published in Frontiers in pharmacology (05-06-2024)“…This study examined the time to sputum smear and culture conversion and determinants of conversion, as well as variables associated with treatment outcomes…”
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Actinidia deliciosa Extract as a Promising Supplemental Agent for Hepatic and Renal Complication-Associated Type 2 Diabetes (In Vivo and In Silico-Based Studies)
Published in International journal of molecular sciences (06-09-2023)“…Type 2 diabetes (T2D) is a chronic metabolic condition associated with obesity, oxidative stress-mediated inflammation, apoptosis, and impaired insulin…”
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Anticancer properties of sulforaphane: current insights at the molecular level
Published in Frontiers in oncology (16-06-2023)“…Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus . However, broccoli…”
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Innovating the Synergistic Assets of β-Amino Butyric Acid (BABA) and Selenium Nanoparticles (SeNPs) in Improving the Growth, Nitrogen Metabolism, Biological Activities, and Nutritive Value of Medicago interexta Sprouts
Published in Plants (Basel) (24-01-2022)“…In view of the wide traditional uses of legume sprouts, several strategies have been approved to improve their growth, bioactivity, and nutritive values. In…”
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Analysis of prevalence of adverse events connected with anti-tuberculosis drugs during pregnancy: A meta-analysis
Published in Heliyon (01-12-2023)“…Mycobacterium tuberculosis infection is transmitted among humans via airborne droplets. The drugs used in the initial treatment regimen for tuberculosis (TB)…”
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GC-MS-based profiling and ameliorative potential of Carissa opaca Stapf ex Haines fruit against cardiac and testicular toxicity: An In vivo study
Published in Heliyon (01-08-2023)“…Fruit of Carissa opaca Stapf ex Haines (C. opaca) is a feed additive and is commonly used against cardiac dysfunction, fever, asthma, diarrhea,…”
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The Role of Vitamin D in Reducing the Risk of Metabolic Disturbances That Cause Cardiovascular Diseases
Published in Journal of cardiovascular development and disease (11-05-2023)“…Among the most common problems facing public health today is a lack of vitamin D, which plays a role in the physiological processes of chronic illness…”
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Antidepressant-like Effects of Renin Inhibitor Aliskiren in an Inflammatory Mouse Model of Depression
Published in Brain sciences (17-05-2022)“…Depression is considered a neuropsychic disease that has global prevalence and is associated with disability. The pathophysiology of depression is not well…”
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Effects of Thymoquinone Alone or in Combination with Losartan on the Cardiotoxicity Caused by Oxidative Stress and Inflammation in Hypercholesterolemia
Published in Journal of cardiovascular development and disease (01-12-2022)“…Dietary cholesterol accelerates oxidative and pro-inflammatory processes, causing hypercholesterolemia and cardiovascular diseases. Thus, the purpose of the…”
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Pharmacological features, health benefits and clinical implications of honokiol
Published in Journal of biomolecular structure & dynamics (13-10-2023)“…Honokiol (HNK) is a natural polyphenolic compound extracted from the bark and leaves of Magnolia grandiflora. It has been traditionally used as a medicinal…”
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Discovering Promising Biomarkers and Therapeutic Targets for Duchenne Muscular Dystrophy: a Multiomics Meta-Analysis Approach
Published in Molecular neurobiology (01-08-2024)“…Duchenne muscular dystrophy (DMD) is a genetic disorder that causes muscle weakness and degeneration. In this study, we identified potential biomarkers and…”
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Preparation and characterization of a ciprofloxacin-loaded nanoparticles incorporated polymeric film dressing
Published in RSC advances (29-08-2024)“…In an effort to prepare a modern polysaccharide-based dressing for sustained/prolonged delivery of the antibacterial agent to prevent and control skin wound…”
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A review on mechanistic insights into structure and function of dystrophin protein in pathophysiology and therapeutic targeting of Duchenne muscular dystrophy
Published in International journal of biological macromolecules (01-04-2024)“…Duchenne Muscular Dystrophy (DMD) is an X-linked recessive genetic disorder characterized by progressive and severe muscle weakening and degeneration. Among…”
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Targeting inhibition of microtubule affinity regulating kinase 4 by Harmaline: Strategy to combat Alzheimer's disease
Published in International journal of biological macromolecules (01-01-2023)“…Microtubule-affinity regulating kinase 4 (MARK4) is linked with the development of cancer, diabetes and neurodegenerative diseases. Due to its direct role in…”
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Identification and dynamics of novel scaffolds against Enterococcus faecium serine hydroxymethyltransferase enzyme: a potential target for antibiotics development
Published in Journal of biomolecular structure & dynamics (02-12-2024)“…Serine hydroxymethyltransferase enzyme is a significant player in purine, thymidylate, and L-serine biosynthesis and has been tagged as a potential target for…”
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Identification of mitogen‐activated protein kinase 7 inhibitors from natural products: Combined virtual screening and dynamic simulation studies
Published in Journal of molecular recognition (01-01-2024)“…Mitogen‐activated protein kinase 7 (MAPK7) is a serine/threonine protein kinase that belongs to the MAPK family and plays a vital role in various cellular…”
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Antioxidative and ROS-dependent apoptotic effects of Cuscuta reflexa Roxb. stem against human lung cancer: network pharmacology and in vitro experimental validation
Published in Journal of biomolecular structure & dynamics (09-12-2024)“…Lung cancer remains a formidable global health challenge, necessitating the exploration of novel therapeutic approaches. This study investigates the potential…”
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