Search Results - "Algire, Mikkel A."

PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow by Hopkins, Todd A, Ainsworth, William B, Ellis, Paul A, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Abraham, Vivek C, Algire, Mikkel A, Shi, Yan, Olson, Amanda M, Johnson, Eric F, Wilsbacher, Julie L, Maag, David

“…PARP inhibitors have recently been approved as monotherapies for the treatment of recurrent ovarian cancer and metastatic -associated breast cancer, and…”
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The Eukaryotic Translation Initiation Factors eIF1 and eIF1A Induce an Open Conformation of the 40S Ribosome by Passmore, Lori A., Schmeing, T. Martin, Maag, David, Applefield, Drew J., Acker, Michael G., Algire, Mikkel A., Lorsch, Jon R., Ramakrishnan, V.

“…Initiation of translation is the process by which initiator tRNA and the start codon of mRNA are positioned in the ribosomal P site. In eukaryotes, one of the…”
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One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome by Gibson, Daniel G, Benders, Gwynedd A, Axelrod, Kevin C, Zaveri, Jayshree, Algire, Mikkel A, Moodie, Monzia, Montague, Michael G, Venter, J. Craig, Smith, Hamilton O, Hutchison, Clyde A. III

“…We previously reported assembly and cloning of the synthetic Mycoplasma genitalium JCVI-1.0 genome in the yeast Saccharomyces cerevisiae by recombination of…”
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Synthetic generation of influenza vaccine viruses for rapid response to pandemics by Dormitzer, Philip R, Suphaphiphat, Pirada, Gibson, Daniel G, Wentworth, David E, Stockwell, Timothy B, Algire, Mikkel A, Alperovich, Nina, Barro, Mario, Brown, David M, Craig, Stewart, Dattilo, Brian M, Denisova, Evgeniya A, De Souza, Ivna, Eickmann, Markus, Dugan, Vivien G, Ferrari, Annette, Gomila, Raul C, Han, Liqun, Judge, Casey, Mane, Sarthak, Matrosovich, Mikhail, Merryman, Chuck, Palladino, Giuseppe, Palmer, Gene A, Spencer, Terika, Strecker, Thomas, Trusheim, Heidi, Uhlendorff, Jennifer, Wen, Yingxia, Yee, Anthony C, Zaveri, Jayshree, Zhou, Bin, Becker, Stephan, Donabedian, Armen, Mason, Peter W, Glass, John I, Rappuoli, Rino, Venter, J Craig

“…During the 2009 H1N1 influenza pandemic, vaccines for the virus became available in large quantities only after human infections peaked. To accelerate vaccine…”
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SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding by Curtin, Michael L., Pliushchev, Marina A., Li, Huan-Qiu, Torrent, Maricel, Dietrich, Justin D., Jakob, Clarissa G., Zhu, Haizhong, Zhao, Hongyu, Wang, Ying, Ji, Zhiqin, Clark, Richard F., Sarris, Kathy A., Selvaraju, Sujatha, Shaw, Bailin, Algire, Mikkel A., He, Yupeng, Richardson, Paul L., Sweis, Ramzi F., Sun, Chaohong, Chiang, Gary G., Michaelides, Michael R.

“…[Display omitted] Herein we disclose SAR studies of a series of dimethylamino pyrrolidines which we recently reported as novel inhibitors of the PRC2 complex…”
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Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo by Cheung, Yuen-Nei, Maag, David, Mitchell, Sarah F, Fekete, Christie A, Algire, Mikkel A, Takacs, Julie E, Shirokikh, Nikolay, Pestova, Tatyana, Lorsch, Jon R, Hinnebusch, Alan G

“…Selection of the AUG start codon is a key step in translation initiation requiring hydrolysis of GTP in the eIF2*GTP*Met-tRNA(i)(Met) ternary complex (TC) and…”
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New Selectable Marker for Manipulating the Simple Genomes of Mycoplasma Species by ALGIRE, Mikkel A, LARTIGUE, Carole, THOMAS, David W, ASSAD-GARCIA, Nacyra, GLASS, John I, MERRYMAN, Chuck

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation by Algire, Mikkel A, Maag, David, Lorsch, Jon R

“…Irreversible GTP hydrolysis by eIF2 is a critical step in translation initiation in eukaryotes because it is thought to commit the translational machinery to…”
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A Type III restriction–modification system in Mycoplasma mycoides subsp. capri by Algire, Mikkel A., Montague, Michael G., Vashee, Sanjay, Lartigue, Carole, Merryman, Chuck

“…The sequenced genome of Mycoplasma mycoides subsp. capri revealed the presence of a Type III restriction–modification system (MmyCI). The methyltransferase…”
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N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection by Fekete, Christie A, Mitchell, Sarah F, Cherkasova, Vera A, Applefield, Drew, Algire, Mikkel A, Maag, David, Saini, Adesh K, Lorsch, Jon R, Hinnebusch, Alan G

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Development and characterization of a reconstituted yeast translation initiation system by ALGIRE, MIKKEL A., MAAG, DAVID, SAVIO, PETER, ACKER, MICHAEL G., TARUN, SALVADOR Z., SACHS, ALAN B., ASANO, KATSURA, NIELSEN, KLAUS H., OLSEN, DEANNE S., PHAN, LON, HINNEBUSCH, ALAN G., LORSCH, JON R.

“…To provide a bridge between in vivo and in vitro studies of eukaryotic translation initiation, we have developed a reconstituted translation initiation system…”
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Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome by Gibson, Daniel G, Benders, Gwynedd A, Andrews-Pfannkoch, Cynthia, Denisova, Evgeniya A, Baden-Tillson, Holly, Zaveri, Jayshree, Stockwell, Timothy B, Brownley, Anushka, Thomas, David W, Algire, Mikkel A, Merryman, Chuck, Young, Lei, Noskov, Vladimir N, Glass, John I, Venter, J. Craig, Hutchison, Clyde A. III, Smith, Hamilton O

“…We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type…”
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The 5′-7-Methylguanosine Cap on Eukaryotic mRNAs Serves Both to Stimulate Canonical Translation Initiation and to Block an Alternative Pathway by Mitchell, Sarah F., Walker, Sarah E., Algire, Mikkel A., Park, Eun-Hee, Hinnebusch, Alan G., Lorsch, Jon R.

“…Translational control is frequently exerted at the stage of mRNA recruitment to the initiating ribosome. We have reconstituted mRNA recruitment to the 43S…”
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Creating Bacterial Strains from Genomes That Have Been Cloned and Engineered in Yeast by Lartigue, Carole, Vashee, Sanjay, Algire, Mikkel A, Chuang, Ray-Yuan, Benders, Gwynedd A, Ma, Li, Noskov, Vladimir N, Denisova, Evgeniya A, Gibson, Daniel G, Assad-Garcia, Nacyra, Alperovich, Nina, Thomas, David W, Merryman, Chuck, Hutchison, Clyde A. III, Smith, Hamilton O, Venter, J. Craig, Glass, John I

“…We recently reported the chemical synthesis, assembly, and cloning of a bacterial genome in yeast. To produce a synthetic cell, the genome must be transferred…”
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Cloning whole bacterial genomes in yeast by Benders, Gwynedd A, Noskov, Vladimir N, Denisova, Evgeniya A, Lartigue, Carole, Gibson, Daniel G, Assad-Garcia, Nacyra, Chuang, Ray-Yuan, Carrera, William, Moodie, Monzia, Algire, Mikkel A, Phan, Quang, Alperovich, Nina, Vashee, Sanjay, Merryman, Chuck, Venter, J. Craig, Smith, Hamilton O, Glass, John I, Hutchison, Clyde A. III

“…Most microbes have not been cultured, and many of those that are cultivatable are difficult, dangerous or expensive to propagate or are genetically…”
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SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) by Curtin, Michael L., Heyman, H. Robin, Clark, Richard F., Sorensen, Bryan K., Doherty, George A., Hansen, T. Matthew, Frey, Robin R., Sarris, Kathy A., Aguirre, Ana L., Shrestha, Anurupa, Tu, Noah, Woller, Kevin, Pliushchev, Marina A., Sweis, Ramzi F., Cheng, Min, Wilsbacher, Julie L., Kovar, Peter J., Guo, Jun, Cheng, Dong, Longenecker, Kenton L., Raich, Diana, Korepanova, Alla V., Soni, Nirupama B., Algire, Mikkel A., Richardson, Paul L., Marin, Violeta L., Badagnani, Ilaria, Vasudevan, Anil, Buchanan, F. Greg, Maag, David, Chiang, Gary G., Tse, Chris, Michaelides, Michael R.

“…[Display omitted] Herein we disclose SAR studies that led to a series of isoindoline ureas which we recently reported were first-in-class, non-substrate…”
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N‐ and C‐terminal residues of eIF1A have opposing effects on the fidelity of start codon selection by Fekete, Christie A, Mitchell, Sarah F, Cherkasova, Vera A, Applefield, Drew, Algire, Mikkel A, Maag, David, Saini, Adesh K, Lorsch, Jon R, Hinnebusch, Alan G

“…Translation initiation factor eIF1A stimulates preinitiation complex (PIC) assembly and scanning, but the molecular mechanisms of its functions are not…”
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Communication between Eukaryotic Translation Initiation Factors 5 and 1A within the Ribosomal Pre-initiation Complex Plays a Role in Start Site Selection by Maag, David, Algire, Mikkel A., Lorsch, Jon R.

“…During eukaryotic translation initiation, the 43 S ribosomal pre-initiation complex scans the mRNA in search of an AUG codon at which to begin translation…”
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Where to begin? The mechanism of translation initiation codon selection in eukaryotes by Algire, Mikkel A, Lorsch, Jon R

“…Selecting the codon at which to begin translation is a complicated event in an already complicated process. Many protein initiation factors (eIFs) have been…”
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Restrictionless cloning by Algire, Mikkel A

“…Many methods have been developed for the cloning of PCR products. These methods include blunt-end cloning, TA cloning, and using restriction sites incorporated…”
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