Clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction as a palatal dressing material compared to Alveogyl: randomized clinical trial

Clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction as a palatal dressing material compared to Alveogyl: randomized clinical trial

This study assessed the clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction (OPMF) solid dispersion as a palatal dressing material, compared with Alveogyl, in a randomized clinical trial. After harvesting free gingival grafts for 18 patients in three groups, the donor site in...

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Bibliographic Details
Published in:Scientific reports Vol. 14; no. 1; p. 3067
Main Authors: Alghriany, Alzahraa A., Ali, Ahmed U., Khallaf, Iman S. A., Hassan, Abeer S., Sayed, Marwa A., Fikry, Ahmed Mortada
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 06-02-2024
Nature Publishing Group
Nature Portfolio
Subjects:
692/1807
692/308
692/699
692/700
Analgesics
Clinical trials
Flavonoids
Hemostasis
Humanities and Social Sciences
multidisciplinary
Pain
Science
Science (multidisciplinary)
Statistical analysis
Wound healing
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Summary:This study assessed the clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction (OPMF) solid dispersion as a palatal dressing material, compared with Alveogyl, in a randomized clinical trial. After harvesting free gingival grafts for 18 patients in three groups, the donor site in group I received OPMF; group II received Alveogyl; and group III received placebo dough material. The visual analog scale (VAS) pain score in group I showed the lowest value in week one without a significant difference. In week 2, there was a substantial decrease in pain in group I compared to group III. Week 4 showed reduced pain scores in all groups without significant differences. The results of the number of analgesic pills revealed, after 1 week, the lowest number of pills consumed in group I, with a considerable difference compared to group III. Healing process results showed that group I had the highest healing values in each interval, with a significant difference between group I and group III at 1 and 2 weeks. Color matching parameter showed slight differences between the groups’ readings in favor of group I in all intervals without a statistically significant difference. The results suggest OPMF as a palatal dressing material that facilitates hemostasis, pain relief, and palatal wound healing.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-53511-4