Search Results - "Alghrably, Mawadda"
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Metal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin
Published in Molecules (Basel, Switzerland) (05-08-2021)“…Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of…”
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Using NMR spectroscopy to investigate the role played by copper in prion diseases
Published in Neurological sciences (01-09-2020)“…Prion diseases are a group of rare neurodegenerative disorders that develop as a result of the conformational conversion of normal prion protein (PrP C ) to…”
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"What Doesn't Kill You Makes You Stronger": Future Applications of Amyloid Aggregates in Biomedicine
Published in Molecules (Basel, Switzerland) (11-11-2020)“…Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer's disease, but at the same time a range of functional amyloids are…”
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Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases
Published in Pharmaceutics (21-12-2021)“…Neurodegenerative diseases are a serious and widespread global public health burden amongst aging populations. The total estimated worldwide global cost of…”
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Therapeutic Properties of Vanadium Complexes
Published in Inorganics (01-12-2022)“…Vanadium is a hard, silver-grey transition metal found in at least 60 minerals and fossil fuel deposits. Its oxide and other vanadium salts are toxic to…”
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Metabolites from Marine Macroorganisms of the Red Sea Acting as Promoters or Inhibitors of Amylin Aggregation
Published in Biomolecules (Basel, Switzerland) (06-08-2024)“…Amylin is part of the endocrine pancreatic system that contributes to glycemic control, regulating blood glucose levels. However, human amylin has a high…”
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Exploring the central region of amylin and its analogs aggregation: the influence of metal ions and residue substitutions
Published in Frontiers in chemistry (08-07-2024)“…Human amylin (hIAPP) is found in the form of amyloid deposits within the pancreatic cells of nearly all patients diagnosed with type 2 diabetes mellitus…”
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Preparation and characterization of natural melanin and its nanocomposite formed by copper doping
Published in Nano select (01-12-2022)“…Natural Melanins have received great interest due to their structural, thermostability, electrochemical and paramagnetic properties. Pure melanin (Mel) is…”
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Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells
Published in Pharmaceutics (03-06-2021)“…In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each…”
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Interaction of amylin species with transition metals and membranes
Published in Journal of inorganic biochemistry (01-02-2019)“…Islet Amyloid Polypeptide (IAPP), also known as amylin, is a 37-amino-acid peptide hormone that is secreted by pancreatic islet β-cells. Amylin is…”
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Mitigating diabetes associated with reactive oxygen species (ROS) and protein aggregation through pharmacological interventions
Published in RSC advances (28-05-2024)“…Diabetes mellitus, a complex metabolic disorder, presents a growing global health challenge. In 2021, there were 529 million diabetics worldwide. At the…”
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Copper(II) and Amylin Analogues: A Complicated Relationship
Published in Inorganic chemistry (17-02-2020)“…Protein aggregation has attracted substantial interest because of its role in causing many serious illnesses, such as neurodegenerative diseases and type II…”
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Living with the enemy: from protein-misfolding pathologies we know, to those we want to know
Published in Ageing research reviews (01-09-2021)“…•Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder and model for misfolding protein diseases.•AATD polymorphism leads to essential metal ions (iron,…”
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