Search Results - "Alger, BE"

GABAergic and developmental influences on homosynaptic LTD and depotentiation in rat hippocampus by Wagner, JJ, Alger, BE

“…Low-frequency (1 Hz) stimulation (LFS) was used to elicit long-term depression (LTD) or depotentiation of excitatory transmission of the Schaffer collateral…”
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Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus by Alger, Bradley E, Kim, Jimok

“…In hippocampal pyramidal cells, a rise in Ca2+ releases endocannabinoids that activate the presynaptic cannabinoid receptor (CB1R) and transiently reduce…”
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Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids by Alger, Bradley E

“…This review covers recent developments in the cellular neurophysiology of retrograde signaling in the mammalian central nervous system. Normally at a chemical…”
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Calcium dependence of depolarization-induced suppression of inhibition in rat hippocampal CA1 pyramidal neurons by Lenz, R. A., Alger, B. E.

“…We made whole-cell recordings from CA1 pyramidal cells in the rat hippocampal slice preparation to study the calcium (Ca 2+ ) dependence of…”
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Endocannabinoids facilitate the induction of LTP in the hippocampus by Alger, Bradley E, Carlson, Gregory, Wang, Yue

“…Exogenous cannabinoids disrupt behavioral learning and impede induction of long-term potentiation (LTP) in the hippocampus, yet endogenous cannabinoids…”
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Activation of Muscarinic Acetylcholine Receptors Enhances the Release of Endogenous Cannabinoids in the Hippocampus by Kim, Jimok, Isokawa, Masako, Ledent, Catherine, Alger, Bradley E

“…Endogenous cannabinoids (endocannabinoids) are endogenous compounds that resemble the active ingredient of marijuana and activate the cannabinoid receptor in…”
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Multiple Mechanisms of Endocannabinoid Response Initiation in Hippocampus by Edwards, David A, Kim, Jimok, Alger, Bradley E

“…Department of Physiology, and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland Submitted 3 August 2005; accepted in…”
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Metabotropic Glutamate Receptors Drive the Endocannabinoid System in Hippocampus by Varma, Namita, Carlson, Gregory C, Ledent, Catherine, Alger, Bradley E

“…Endocannabinoids are key intercellular signaling molecules in the brain, but the physiological regulation of the endocannabinoid system is not understood. We…”
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Ryanodine Receptor Regulates Endogenous Cannabinoid Mobilization in the Hippocampus by Isokawa, Masako, Alger, Bradley E

“…Department of Physiology, University of Maryland, Baltimore, Maryland Submitted 21 September 2005; accepted in final form 2 February 2006 Endogenous…”
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Random Response Fluctuations Lead to Spurious Paired-Pulse Facilitation by Kim, Jimok, Alger, Bradley E

“…We studied paired-pulse depression (PPD) of GABA(A)ergic IPSCs under conditions of reduced transmitter release (caused by Cd(2+), baclofen, or reduced stimulus…”
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Retrograde endocannabinoid regulation of GABAergic inhibition in the rat dentate gyrus granule cell by Isokawa, Masako, Alger, Bradley E.

“…The dentate gyrus is a key input gateway for the hippocampus, and dentate function is potently regulated by GABAergic inhibition. GABAergic inhibition is…”
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Endocannabinoid modulation of fear responses: learning and state-dependent performance effects by Reich, CG, Mohammadi, MH, Alger, BE

“…Recently, disruption of the endogenous cannabinoid (endocannabinoid, eCB) system was found to impair extinction in delay and contextual fear conditioning…”
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Mechanisms of Neuronal Hyperexcitability Caused by Partial Inhibition of Na+-K+-ATPases in the Rat CA1 Hippocampal Region by Vaillend, Cyrille, Mason, Susanne E, Cuttle, Matthew F, Alger, Bradley E

“…Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201 Vaillend, Cyrille, Susanne E. Mason, Matthew F. Cuttle, and…”
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Endocannabinoids: Getting the Message across by Alger, Bradley E.

“…The endocannabinoids have emerged as important intercellular signals in the nervous system. It has been suggested that passive diffusion alone is sufficient…”
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Protein kinase C activators block specific calcium and potassium current components in isolated hippocampal neurons by Doerner, D, Pitler, TA, Alger, BE

“…Whole-cell voltage-clamp techniques were used to study the effects of the protein kinase C (PKC) activators phorbol esters and OAG on Ca and K currents in…”
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Endocannabinoid Signaling Dynamics Probed with Optical Tools by Heinbockel, Thomas, Brager, Darrin H, Reich, Christian G, Zhao, Jun, Muralidharan, Sukumaran, Alger, Bradley E, Kao, Joseph P. Y

“…Intercellular signaling dynamics critically influence the functional roles that the signals can play. Small lipids are synthesized and released from neurons,…”
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Regulation of IPSP Theta Rhythm by Muscarinic Receptors and Endocannabinoids in Hippocampus by Reich, Christian G, Karson, Miranda A, Karnup, Sergei V, Jones, Lauren M, Alger, Bradley E

“…Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland Submitted 10 May 2005; accepted in final form…”
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Depolarization-induced suppression of GABAergic inhibition in rat hippocampal pyramidal cells: G protein involvement in a presynaptic mechanism by Pitler, T A, Alger, B E

“…Following postsynaptic activation of a pyramidal cell, the degree of GABAergic synaptic inhibition that the cell receives is reduced dramatically for many…”
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Electrophysiological mechanisms of kainic acid-induced epileptiform activity in the rat hippocampal slice by Fisher, RS, Alger, BE

“…Depression of GABA-mediated IPSPs has been proposed to be a crucial factor in the onset of epileptiform activity in most models of epilepsy. To test this idea,…”
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Evidence for Metabotropic Glutamate Receptor Activation in the Induction of Depolarization-Induced Suppression of Inhibition in Hippocampal CA1 by Morishita, Wade, Kirov, Sergei A, Alger, Bradley E

“…Depolarization-induced suppression of inhibition (DSI) is a transient reduction of GABAA receptor-mediated IPSCs that is mediated by a retrograde signal from…”
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