Search Results - "Alfonso Gurpide"

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma by Schalper, Kurt A., Rodriguez-Ruiz, Maria E., Diez-Valle, Ricardo, López-Janeiro, Alvaro, Porciuncula, Angelo, Idoate, Miguel A., Inogés, Susana, de Andrea, Carlos, López-Diaz de Cerio, Ascensión, Tejada, Sonia, Berraondo, Pedro, Villarroel-Espindola, Franz, Choi, Jungmin, Gúrpide, Alfonso, Giraldez, Miriam, Goicoechea, Iosune, Gallego Perez-Larraya, Jaime, Sanmamed, Miguel F., Perez-Gracia, Jose L., Melero, Ignacio

“…Glioblastoma is the most common primary central nervous system malignancy and has a poor prognosis. Standard first-line treatment, which includes surgery…”
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PSA reactivity in extracellular microvesicles to commercial immunoassays by Sandúa, Amaia, Sanmamed, Miguel F., Rodríguez, María, Ancizu-Marckert, Javier, Gúrpide, Alfonso, Perez-Gracia, José L., Alegre, Estibaliz, González, Álvaro

“…•Prostate derived extracellular microvesicles transport PSA at their surface.•PSA in extracellular microvesicles can be measured with conventional…”
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First-line Management of Metastatic Urothelial Cancer: Current and Future Perspectives After the EV-302 and CheckMate-901 Studies by Fenor de la Maza, María Dolores, Villacampa, Guillermo, Miñana, Bernardino, Barbas Bernardos, Guillermo, Andrés, Guillermo, González-Padilla, Daniel Antonio, Ramón de Fata, Fernando, Sanz, Julián, Cambeiro, Mauricio, Aristu, Javier, Gúrpide, Alfonso, Villacampa, Felipe, Gracia, Jose Luis Pérez

“…•Metastatic urothelial carcinoma management is rapidly changing.•A new strategy combining pembrolizumab and enfortumab vedotin has recently arisen as a strong…”
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Characterization of the perioperative changes of exosomal immune-related cytokines induced by prostatectomy in early-stage prostate cancer patients by Macías, Mónica, García-Cortés, Ángel, Torres, Marcos, Ancizu-Marckert, Javier, Ignacio Pascual, Juan, Díez-Caballero, Fernando, Enrique Robles, José, Rosell, David, Miñana, Bernardino, Mateos, Beatriz, Ajona, Daniel, Sánchez-Bayona, Rodrigo, Bedialauneta, Oihane, Chocarro, Susana, Navarro, Ana, Andueza, María P., Gúrpide, Alfonso, Perez-Gracia, Jose Luis, Alegre, Estibaliz, González, Álvaro

“…•We analyzed MDSCs cytokines in serum exosomes from prostate cancer patients.•CCL2, CXCL2, CXCL5, CXCL8, MIF, S100A9 and TGF-ß were detected in exosomes.•MIF,…”
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Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma by Prior, Celia, Perez-Gracia, Jose Luis, Garcia-Donas, Jesus, Rodriguez-Antona, Cristina, Guruceaga, Elizabeth, Esteban, Emilio, Suarez, Cristina, Castellano, Daniel, del Alba, Aránzazu González, Lozano, Maria Dolores, Carles, Joan, Climent, Miguel Angel, Arranz, Jose Angel, Gallardo, Enrique, Puente, Javier, Bellmunt, Joaquim, Gurpide, Alfonso, Lopez-Picazo, Jose Maria, Hernandez, Alvaro Gonzalez, Mellado, Begoña, Martínez, Esther, Moreno, Fernando, Font, Albert, Calvo, Alfonso

“…To identify tissue microRNAs predictive of sunitinib activity in patients with metastatic renal-cell-carcinoma (MRCC) and to evaluate in vitro their mechanism…”
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Programmed death–ligand 1 expression on direct Pap‐stained cytology smears from non–small cell lung cancer: Comparison with cell blocks and surgical resection specimens by Lozano, Maria D., Abengozar‐Muela, Marta, Echeveste, José I., Subtil, José Carlos, Bertó, Juan, Gúrpide, Alfonso, Calvo, Alfonso, Andrea, Carlos E.

“…Background Programmed death–ligand 1 (PD‐L1) expression, as assessed by immunohistochemistry (IHC), is used to select patients with non–small cell lung cancer…”
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Phase II Proof-of-Concept Study of Pazopanib Monotherapy in Treatment-Naive Patients With Stage I/II Resectable Non–Small-Cell Lung Cancer by ALTORKI, Nasser, LANE, Maureen E, MITCHELL, John D, TACHDJIAN, Sabrina, SUZANNE SWANN, R, HUFF, Anne, ROYCHOWDHURY, Debasish F, REEVES, Anthony, OTTESEN, Lone H, YANKELEVITZ, David F, BAUER, Thomas, LEE, Paul C, GUARINO, Michael J, PASS, Harvey, FELIP, Enriqueta, PEYLAN-RAMU, Nili, GURPIDE, Alfonso, GRANNIS, Frederic W

“…Patients with early-stage, resectable, non-small-cell lung cancer (NSCLC) are at risk for recurrent disease, and 5-year survival rates do not exceed 75%…”
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Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism by Labiano, Sara, Palazón, Asis, Bolaños, Elixabet, Azpilikueta, Arantza, Sánchez-Paulete, Alfonso R., Morales-Kastresana, Aizea, Quetglas, Jose I., Perez-Gracia, José L., Gúrpide, Alfonso, Rodriguez-Ruiz, Maria, Aznar, M. Angela, Jure-Kunkel, Maria, Berraondo, Pedro, Melero, Ignacio

“…Hypoxia is a common feature in solid tumors that has been implicated in immune evasion. Previous studies from our group have shown that hypoxia upregulates the…”
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The Dynamic Use of EGFR Mutation Analysis in Cell-Free DNA as a Follow-Up Biomarker during Different Treatment Lines in Non-Small-Cell Lung Cancer Patients by Perez-Gracia, Jose L., González, Alvaro, Gil-Bazo, Ignacio, Gúrpide, Alfonso, Andueza, Maria P., Mateos, Beatriz, Patiño-García, Ana, Alkorta-Aranburu, Gorka, Alegre, Estibaliz, Macías, Mónica, Lopez-Picazo, Jose M.

“…Epidermal growth factor receptor (EGFR) mutational testing in advanced non-small-cell lung cancer (NSCLC) is usually performed in tumor tissue, although cfDNA…”
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Assessment of Epidermal Growth Factor Receptor and K‐Ras Mutation Status in Cytological Stained Smears of Non‐Small Cell Lung Cancer Patients: Correlation with Clinical Outcomes by Lozano, Maria D., Zulueta, Javier J., Echeveste, Jose I., Gúrpide, Alfonso, Seijo, Luis M., Martín‐Algarra, Salvador, Barrio, Anabel, Pio, Ruben, Idoate, Miguel Angel, Labiano, Tania, Perez‐Gracia, Jose Luis

“…Objective. Epidermal growth factor receptor (EGFR) and K‐ras mutations guide treatment selection in non‐small cell lung cancer (NSCLC) patients. Although…”
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Complement activation mediates cetuximab inhibition of non-small cell lung cancer tumor growth in vivo by Hsu, Yi-Fan, Ajona, Daniel, Corrales, Leticia, Lopez-Picazo, Jose M, Gurpide, Alfonso, Montuenga, Luis M, Pio, Ruben

“…Cetuximab, an antibody targeting the epidermal growth factor receptor (EGFR), increases survival in patients with advanced EGFR-positive non-small cell lung…”
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Long-Term Outcome of Critically Ill Advanced Cancer Patients Managed in an Intermediate Care Unit by Fernández Ros, Nerea, Alegre, Félix, Rodríguez Rodriguez, Javier, Landecho, Manuel F, Sunsundegui, Patricia, Gúrpide, Alfonso, Lecumberri, Ramón, Sanz, Eva, García, Nicolás, Quiroga, Jorge, Lucena, Juan Felipe

“…Background: To analyze the long-term outcomes for advanced cancer patients admitted to an intermediate care unit (ImCU), an analysis of a do not resuscitate…”
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Combined clinical and genomic signatures for the prognosis of early stage non-small cell lung cancer based on gene copy number alterations by Aramburu, Ander, Zudaire, Isabel, Pajares, María J, Agorreta, Jackeline, Orta, Alberto, Lozano, María D, Gúrpide, Alfonso, Gómez-Román, Javier, Martinez-Climent, Jose A, Jassem, Jacek, Skrzypski, Marcin, Suraokar, Milind, Behrens, Carmen, Wistuba, Ignacio I, Pio, Ruben, Rubio, Angel, Montuenga, Luis M

“…The development of a more refined prognostic methodology for early non-small cell lung cancer (NSCLC) is an unmet clinical need. An accurate prognostic tool…”
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Randomized pharmacokinetic study comparing subcutaneous and intravenous palonosetron in cancer patients treated with platinum based chemotherapy by Sadaba, Belen, del Barrio, Anabel, Campanero, Miguel Angel, Azanza, Jose Ramon, Gomez-Guiu, Almudena, Lopez-Picazo, Jose Maria, Algarra, Salvador Martin, Guillén Grimá, Francisco, Blanco Prieto, Maria, Perez-Gracia, Jose Luis, Gurpide, Alfonso

“…Palonosetron is a potent second generation 5- hydroxytryptamine-3 selective antagonist which can be administered by either intravenous (IV) or oral routes, but…”
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Genomic characterization of individuals presenting extreme phenotypes of high and low risk to develop tobacco‐induced lung cancer by Fusco, Juan Pablo, Pita, Guillermo, Pajares, María José, Andueza, Maria Pilar, Patiño‐García, Ana, de‐Torres, Juan P., Gurpide, Alfonso, Zulueta, Javier, Alonso, Rosario, Alvarez, Nuria, Pio, Ruben, Melero, Ignacio, Sanmamed, Miguel F., Rodriguez Ruiz, Maria, Gil‐Bazo, Ignacio, Lopez‐Picazo, Jose María, Casanova, Ciro, Baz Davila, Rebeca, Agudo, Antonio, Lozano, Maria Dolores, Gonzalez, Alvaro, Sala, Nuria, Ardanaz, Eva, Benitez, Javier, Montuenga, Luis, Gonzalez‐Neira, Anna, Perez‐Gracia, Jose Luis

“…Single nucleotide polymorphisms (SNPs) may modulate individual susceptibility to carcinogens. We designed a genome‐wide association study to characterize…”
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Large cell carcinoma of the lung: an endangered species? by Pardo, Javier, Martinez-Peñuela, Ana M, Sola, Jesús J, Panizo, Angel, Gúrpide, Alfonso, Martinez-Peñuela, Jose M, Lozano, Maria D

“…This study aims to evaluate large cell carcinomas (LCC) of the lung with a panel of immunohistochemical markers in an attempt to identify tumors belonging to…”
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Variations in Molecular Profile in NSCLC Can Be Analyzed Using Cytological Samples: Development of EGFR Resistance Mutations and Coexistence of ALK-EML4 Translocation in an EGFR-Sensitive Patient by Lozano, Maria D., Labiano, Tania, Zudaire, Isabel, Subtil, Jose C., Gúrpide, Alfonso, Echeveste, Jose I., Zulueta, Javier J., Martín-Algarra, Salvador, Pérez-Gracia, Jose L.

“…As a result of therapeutic advances, a revolution is taking place in the lung cancer field with major implications for pathologic diagnosis and tissue…”
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Dosimetric analysis of the patterns of local failure observed in patients with locally advanced non-small cell lung cancer treated with neoadjuvant chemotherapy and concurrent conformal (3D-CRT) chemoradiation by Moreno-Jiménez, Marta, Aristu, Javier, López-Picazo, José María, Ramos, Luis Isaac, Gúrpide, Alfonso, Gómez-Iturriaga, Alfonso, Valero, Jeannete, Martínez-Monge, Rafael

“…Abstract Purpose Three-dimensional conformal radiation therapy (3D-CRT) represents an advance in the better delineation of the target contours and more…”
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Does Surgery Have a Role in the Treatment of Small Cell Lung Cancer (SCLC)? A Single Institution Experience by Torre, Wenceslao, MD, Tamura, Akiko, MD, Gurpide, Alfonso, MD, Gracia, Jose Luis Perez, MD, Bazo, Ignacio Gil, MD, Picazo, Jose Lopez, MD

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Selection of extreme phenotypes: the role of clinical observation in translational research by Pérez-Gracia, José Luis, Gúrpide, Alfonso, Ruiz-Ilundain, María Gloria, Alegría, Carlos Alfaro, Colomer, Ramon, García-Foncillas, Jesús, Melero Bermejo, Ignacio

“…Systematic collection of phenotypes and their correlation with molecular data has been proposed as a useful method to advance in the study of disease. Although…”
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