Search Results - "Alfonso, J. C. L."

Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy by Alfonso, J C L, Berk, L

“…Standard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is…”
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A dose-volume histogram based decision-support system for dosimetric comparison of radiotherapy treatment plans by Alfonso, J C L, Herrero, M A, Núñez, L

“…The choice of any radiotherapy treatment plan is usually made after the evaluation of a few preliminary isodose distributions obtained from different beam…”
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The biology and mathematical modelling of glioma invasion: a review by Alfonso, J. C. L., Talkenberger, K., Seifert, M., Klink, B., Hawkins-Daarud, A., Swanson, K. R., Hatzikirou, H., Deutsch, A.

“…Adult gliomas are aggressive brain tumours associated with low patient survival rates and limited life expectancy. The most important hallmark of this type of…”
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Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights by Alfonso, J. C. L., Köhn-Luque, A., Stylianopoulos, T., Feuerhake, F., Deutsch, A., Hatzikirou, H.

“…Gliomas are highly invasive brain tumours characterised by poor prognosis and limited response to therapy. There is an ongoing debate on the therapeutic…”
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Selecting Radiotherapy Dose Distributions by Means of Constrained Optimization Problems by Alfonso, J. C. L., Buttazzo, G., García-Archilla, B., Herrero, M. A., Núñez, L.

“…The main steps in planning radiotherapy consist in selecting for any patient diagnosed with a solid tumor (i) a prescribed radiation dose on the tumor,…”
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In-silico insights on the prognostic potential of immune cell infiltration patterns in the breast lobular epithelium by Alfonso, J. C. L., Schaadt, N. S., Schönmeyer, R., Brieu, N., Forestier, G., Wemmert, C., Feuerhake, F., Hatzikirou, H.

“…Scattered inflammatory cells are commonly observed in mammary gland tissue, most likely in response to normal cell turnover by proliferation and apoptosis, or…”
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Cancer therapeutic potential of combinatorial immuno- and vasomodulatory interventions by Hatzikirou, H., Alfonso, J. C. L., Mühle, S., Stern, C., Weiss, S., Meyer-Hermann, M.

“…Currently, most of the basic mechanisms governing tumour–immune system interactions, in combination with modulations of tumour-associated vasculature, are far…”
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In silico tumor control induced via alternating immunostimulating and immunosuppressive phases by Reppas, AI, Alfonso, JCL, Hatzikirou, H

“…Despite recent advances in the field of Oncoimmunology, the success potential of immunomodulatory therapies against cancer remains to be elucidated. One of the…”
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Mathematical modeling of anisotropic avascular tumor growth by Ramírez-Torres, A., Rodríguez-Ramos, R., Merodio, J., Bravo-Castillero, J., Guinovart-Díaz, R., Alfonso, J.C.L.

“…•We provide a theoretical framework in the context of continuum mechanics to investigate the growth of avascular tumor spheroids.•Anisotropic growth is…”
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Action of body forces in tumor growth by Ramírez-Torres, A., Rodríguez-Ramos, R., Merodio, J., Bravo-Castillero, J., Guinovart-Díaz, R., Alfonso, J.C.L.

“…In the present work two mathematical models are proposed to investigate tumor growth within the framework of continuum mechanics. In particular, the tumor is…”
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In silico tumor control induced via alternating immunostimulating and immunosuppressive phases by Reppas, A. I, Alfonso, J. C. L, Hatzikirou, H

“…Despite recent advances in the field of Oncoimmunology, the success potential of immunomodulatory therapies against cancer remains to be elucidated. One of the…”
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Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights by Alfonso, J. C. L, Kohn-Luque, A, Stylianopoulos, T, Feuerhake, F, Deutsch, A, Hatzikirou, H

“…There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies…”
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Cancer therapeutic potential of combinatorial immuno- and vaso-modulatory interventions by Hatzikirou, H, Alfonso, J. C. L, Muhle, S, Stern, C, Weiss, S, Meyer-Hermann, M

“…Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far…”
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