Search Results - "Alfoldi, Robert"

Patient-specific Boolean models of signalling networks guide personalised treatments by Montagud, Arnau, Béal, Jonas, Tobalina, Luis, Traynard, Pauline, Subramanian, Vigneshwari, Szalai, Bence, Alföldi, Róbert, Puskás, László, Valencia, Alfonso, Barillot, Emmanuel, Saez-Rodriguez, Julio, Calzone, Laurence

“…Prostate cancer is the second most occurring cancer in men worldwide. To better understand the mechanisms of tumorigenesis and possible treatment responses, we…”
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Antiproliferative and antimetastatic characterization of an exo-heterocyclic androstane derivative against human breast cancer cell lines by Kulmány, Ágnes E., Frank, Éva, Kovács, Dóra, Kirisits, Kerstin, Krupitza, Georg, Neuperger, Patrícia, Alföldi, Róbert, Puskás, László G., Szebeni, Gábor J., Zupkó, István

“…Cancer in general, and specifically gynaecological neoplasms, represents a major public health issue worldwide. Based on the effect of sex hormones on breast…”
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Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice by Tóth, Melinda Erzsébet, Szegedi, Viktor, Varga, Edina, Juhász, Gábor, Horváth, János, Borbély, Emőke, Csibrány, Balázs, Alföldi, Róbert, Lénárt, Nikolett, Penke, Botond, Sántha, Miklós

“…Hsp27 belongs to the small heat shock protein family, which are ATP-independent chaperones. The most important function of Hsp27 is based on its ability to…”
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Imidazo[1,2- b ]pyrazole-7-Carboxamide Derivative Induces Differentiation-Coupled Apoptosis of Immature Myeloid Cells Such as Acute Myeloid Leukemia and Myeloid-Derived Suppressor Cells by Kotogány, Edit, Balog, József Á, Nagy, Lajos I, Alföldi, Róbert, Bertagnolo, Valeria, Brugnoli, Federica, Demjén, András, Kovács, Anita K, Batár, Péter, Mezei, Gabriella, Szabó, Renáta, Kanizsai, Iván, Varga, Csaba, Puskás, László G, Szebeni, Gábor J

“…Chemotherapy-induced differentiation of immature myeloid progenitors, such as acute myeloid leukemia (AML) cells or myeloid-derived suppressor cells (MDSCs),…”
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Mannich Curcuminoids as Potent Anticancer Agents by Gyuris, Márió, Hackler, László, Nagy, Lajos I., Alföldi, Róbert, Rédei, Eszter, Marton, Annamária, Vellai, Tibor, Faragó, Nóra, Ózsvári, Béla, Hetényi, Anasztázia, Tóth, Gábor K., Sipos, Péter, Kanizsai, Iván, Puskás, László G.

“…A series of novel curcuminoids were synthesised for the first time via a Mannich‐3CR/organocatalysed Claisen–Schmidt condensation sequence. Structure–activity…”
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Single Cell Mass Cytometry of Non-Small Cell Lung Cancer Cells Reveals Complexity of In vivo And Three-Dimensional Models over the Petri-dish by Alföldi, Róbert, Balog, József Á, Faragó, Nóra, Halmai, Miklós, Kotogány, Edit, Neuperger, Patrícia, Nagy, Lajos I, Fehér, Liliána Z, Szebeni, Gábor J, Puskás, László G

“…Single cell genomics and proteomics with the combination of innovative three-dimensional (3D) cell culture techniques can open new avenues toward the…”
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The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms by Kovács, Tibor, Billes, Viktor, Komlós, Marcell, Hotzi, Bernadette, Manzéger, Anna, Tarnóci, Anna, Papp, Diána, Szikszai, Fanni, Szinyákovics, Janka, Rácz, Ákos, Noszál, Béla, Veszelka, Szilvia, Walter, Fruzsina R., Deli, Mária A., Hackler, Laszlo, Alfoldi, Robert, Huzian, Orsolya, Puskas, Laszlo G., Liliom, Hanna, Tárnok, Krisztián, Schlett, Katalin, Borsy, Adrienn, Welker, Ervin, Kovács, Attila L., Pádár, Zsolt, Erdős, Attila, Legradi, Adam, Bjelik, Annamaria, Gulya, Károly, Gulyás, Balázs, Vellai, Tibor

“…Autophagy functions as a main route for the degradation of superfluous and damaged constituents of the cytoplasm. Defects in autophagy are implicated in the…”
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Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2‐b]pyrazole‐7‐carboxamides by Demjén, András, Alföldi, Róbert, Angyal, Anikó, Gyuris, Márió, Hackler, László, Szebeni, Gábor J., Wölfling, János, Puskás, László G., Kanizsai, Iván

“…The synthesis and in vitro cytotoxic characteristics of new imidazo[1,2‐b]pyrazole‐7‐carboxamides were investigated. Following a hit‐to‐lead optimization…”
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Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma In Vitro and In Vivo by Vadovics, Máté, Ho, Jemima, Igaz, Nóra, Alföldi, Róbert, Rakk, Dávid, Veres, Éva, Szücs, Balázs, Horváth, Márton, Tóth, Renáta, Szücs, Attila, Csibi, Andrea, Horváth, Péter, Tiszlavicz, László, Vágvölgyi, Csaba, Nosanchuk, Joshua D, Szekeres, András, Kiricsi, Mónika, Henley-Smith, Rhonda, Moyes, David L, Thavaraj, Selvam, Brown, Rhys, Puskás, László G, Naglik, Julian R, Gácser, Attila

“…Oral squamous cell carcinoma (OSCC) is associated with oral Candida albicans infection, although it is unclear whether the fungus promotes the genesis and…”
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Real architecture For 3D Tissue (RAFT™) culture system improves viability and maintains insulin and glucagon production of mouse pancreatic islet cells by Szebeni, Gabor J., Tancos, Zsuzsanna, Feher, Liliana Z., Alfoldi, Robert, Kobolak, Julianna, Dinnyes, Andras, Puskas, Laszlo G.

“…There is an unmet medical need for the improvement of pancreatic islet maintenance in culture. Due to restricted donor availability it is essential to…”
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Single Cell Mass Cytometry Revealed the Immunomodulatory Effect of Cisplatin Via Downregulation of Splenic CD44+, IL-17A+ MDSCs and Promotion of Circulating IFN-γ+ Myeloid Cells in the 4T1 Metastatic Breast Cancer Model by Balog, József Á, Hackler, Jr, László, Kovács, Anita K, Neuperger, Patrícia, Alföldi, Róbert, Nagy, Lajos I, Puskás, László G, Szebeni, Gábor J

“…The treatment of metastatic breast cancer remained a challenge despite the recent breakthrough in the immunotherapy regimens. Here, we addressed the…”
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Imidazo[1,2- b ]pyrazole-7-carboxamides Induce Apoptosis in Human Leukemia Cells at Nanomolar Concentrations by Szebeni, Gábor J, Balog, József A, Demjén, András, Alföldi, Róbert, Végi, Vanessza L, Fehér, Liliána Z, Mán, Imola, Kotogány, Edit, Gubán, Barbara, Batár, Péter, Hackler, Jr, László, Kanizsai, Iván, Puskás, László G

“…Leukemia, the malignancy of the hematopoietic system accounts for 10% of cancer cases with poor overall survival rate in adults; therefore, there is a high…”
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Achiral Mannich-Base Curcumin Analogs Induce Unfolded Protein Response and Mitochondrial Membrane Depolarization in PANC-1 Cells by Szebeni, Gábor J, Balázs, Árpád, Madarász, Ildikó, Pócz, Gábor, Ayaydin, Ferhan, Kanizsai, Iván, Fajka-Boja, Roberta, Alföldi, Róbert, Hackler, Jr, László, Puskás, László G

“…Achiral Mannich-type curcumin analogs have been synthetized and assayed for their cytotoxic activity. The anti-proliferative and cytotoxic activity of…”
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Introduction of an Ultraviolet C-Irradiated 4T1 Murine Breast Cancer Whole-Cell Vaccine Model by Szebeni, Gábor J, Alföldi, Róbert, Nagy, Lajos I, Neuperger, Patrícia, Gémes, Nikolett, Balog, József Á, Tiszlavicz, László, Puskás, László G

“…The advent of immunotherapy has revolutionized cancer treatments. However, the application of immune checkpoint inhibitors may entail severe side effects, with…”
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Signatures of cell death and proliferation in perturbation transcriptomics data—from confounding factor to effective prediction by Szalai, Bence, Subramanian, Vigneshwari, Holland, Christian H, Alföldi, Róbert, Puskás, László G, Saez-Rodriguez, Julio

“…Abstract Transcriptional perturbation signatures are valuable data sources for functional genomics. Linking perturbation signatures to screenings opens the…”
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Our Critics are Confounded and Resigned ━ Interview with Róbert Alföldi, ex-director of the Hungarian National Theatre, actor, director by Judit Csáki, Róbert Alföldi

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Enantioselective Synthesis of 8-Hydroxyquinoline Derivative, Q134 as a Hypoxic Adaptation Inducing Agent by Hackler, Jr, László, Gyuris, Márió, Huzián, Orsolya, Alföldi, Róbert, Szebeni, Gábor J, Madácsi, Ramóna, Knapp, Levente, Kanizsai, Iván, Puskás, László G

“…Hypoxia is a common feature of neurodegenerative diseases, including Alzheimer's disease that may be responsible for disease pathogenesis and progression…”
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Három-dimenziós in vitro multicelluláris szferoidok fejlesztése és alkalmazása tumorellenes hatóanyagok vizsgálatára by Alföldi, Róbert

“…A dolgozat a során a különböző módon előállított háromdimenziós in vitro sejttenyésztési eljárásokkal kialakított multicelluláris szferoidok vizsgálatát…”
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