Search Results - "Alfini, Renzo"

Dissecting the contribution of O-Antigen and proteins to the immunogenicity of Shigella sonnei generalized modules for membrane antigens (GMMA) by Mancini, Francesca, Gasperini, Gianmarco, Rossi, Omar, Aruta, Maria Grazia, Raso, Maria Michelina, Alfini, Renzo, Biagini, Massimiliano, Necchi, Francesca, Micoli, Francesca

“…GMMA are exosomes released from engineered Gram-negative bacteria resembling the composition of outer membranes. We applied the GMMA technology for the…”
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Exploring the Role of GMMA Components in the Immunogenicity of a 4-Valent Vaccine against Shigella by Mancini, Francesca, Alfini, Renzo, Caradonna, Valentina, Monaci, Valentina, Carducci, Martina, Gasperini, Gianmarco, Piccioli, Diego, Biagini, Massimiliano, Giannelli, Carlo, Rossi, Omar, Pizza, Mariagrazia, Micoli, Francesca

“…Shigellosis is the leading cause of diarrheal disease, especially in children of low- and middle-income countries, and is often associated with anti-microbial…”
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GMMA Is a Versatile Platform to Design Effective Multivalent Combination Vaccines by Micoli, Francesca, Alfini, Renzo, Di Benedetto, Roberta, Necchi, Francesca, Schiavo, Fabiola, Mancini, Francesca, Carducci, Martina, Palmieri, Elena, Balocchi, Cristiana, Gasperini, Gianmarco, Brunelli, Brunella, Costantino, Paolo, Adamo, Roberto, Piccioli, Diego, Saul, Allan

“…Technology platforms are an important strategy to facilitate the design, development and implementation of vaccines to combat high-burden diseases that are…”
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Novel Simple Conjugation Chemistries for Decoration of GMMA with Heterologous Antigens by Di Benedetto, Roberta, Alfini, Renzo, Carducci, Martina, Aruta, Maria Grazia, Lanzilao, Luisa, Acquaviva, Alessandra, Palmieri, Elena, Giannelli, Carlo, Necchi, Francesca, Saul, Allan, Micoli, Francesca

“…Outer Membrane Vesicles (OMV) constitute a promising platform for the development of efficient vaccines. OMV can be decorated with heterologous antigens…”
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Rationalizing the design of a broad coverage Shigella vaccine based on evaluation of immunological cross-reactivity among S. flexneri serotypes by Citiulo, Francesco, Necchi, Francesca, Mancini, Francesca, Rossi, Omar, Aruta, Maria Grazia, Gasperini, Gianmarco, Alfini, Renzo, Rondini, Simona, Micoli, Francesca, Rappuoli, Rino, Saul, Allan, Martin, Laura B

“…No vaccine to protect against an estimated 238,000 shigellosis deaths per year is widely available. S. sonnei is the most prevalent Shigella, and multiple…”
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Generalized Modules for Membrane Antigens as Carrier for Polysaccharides: Impact of Sugar Length, Density, and Attachment Site on the Immune Response Elicited in Animal Models by Micoli, Francesca, Alfini, Renzo, Di Benedetto, Roberta, Necchi, Francesca, Schiavo, Fabiola, Mancini, Francesca, Carducci, Martina, Oldrini, Davide, Pitirollo, Olimpia, Gasperini, Gianmarco, Balocchi, Cristiana, Bechi, Nicoletta, Brunelli, Brunella, Piccioli, Diego, Adamo, Roberto

“…Nanoparticle systems are being explored for the display of carbohydrate antigens, characterized by multimeric presentation of glycan epitopes and special…”
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O-Antigen decorations in Salmonella enterica play a key role in eliciting functional immune responses against heterologous serovars in animal models by Gasperini, Gianmarco, Massai, Luisa, De Simone, Daniele, Raso, Maria Michelina, Palmieri, Elena, Alfini, Renzo, Rossi, Omar, Ravenscroft, Neil, Kuttel, Michelle M, Micoli, Francesca

“…Different serovars of Salmonella enterica cause systemic diseases in humans including enteric fever, caused by S. Typhi and S. Paratyphi A, and invasive…”
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GMMA and Glycoconjugate Approaches Compared in Mice for the Development of a Vaccine against Shigella flexneri Serotype 6 by Raso, Maria Michelina, Gasperini, Gianmarco, Alfini, Renzo, Schiavo, Fabiola, Aruta, Maria Grazia, Carducci, Martina, Forgione, Maria Concetta, Martini, Silvia, Cescutti, Paola, Necchi, Francesca, Micoli, Francesca

“…infections are one of the top causes of diarrhea throughout the world, with being predominant in developing countries. Currently, no vaccines are widely…”
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Testing S. sonnei GMMA with and without Aluminium Salt-Based Adjuvants in Animal Models by Mancini, Francesca, Caradonna, Valentina, Alfini, Renzo, Aruta, Maria Grazia, Vitali, Claudia Giorgina, Gasperini, Gianmarco, Piccioli, Diego, Berlanda Scorza, Francesco, Rossi, Omar, Micoli, Francesca

“…Shigellosis is one of the leading causes of diarrheal disease in low- and middle-income countries, particularly in young children, and is more often associated…”
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(2-Pyridyl)phenyl methanol: a new reagent for metal-free reduction of nitro aromatic compounds by Giomi, Donatella, Alfini, Renzo, Brandi, Alberto

“…As previously reported for 1-(2-pyridyl)-2-propen-1-ol, (2-pyridyl)phenyl methanol is able to react as hydrogen donor towards nitro aromatic and heteroaromatic…”
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Development and Application of a High-Throughput Method for the Purification and Analysis of Surface Carbohydrates from Klebsiella pneumoniae by Nonne, Francesca, Molfetta, Mariagrazia, Nappini, Rebecca, La Guidara, Chiara, Di Benedetto, Roberta, Mfana, Siwaphiwe, Bellich, Barbara, Raso, Maria Michelina, Gasperini, Gianmarco, Alfini, Renzo, Cescutti, Paola, Berlanda Scorza, Francesco, Ravenscroft, Neil, Micoli, Francesca, Giannelli, Carlo

“…(Kp) is a Gram-negative bacterium, and a leading cause of neonatal sepsis in low- and middle-income countries, often associated with anti-microbial resistance…”
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Modeling 1-Cyano-4-Dimethylaminopyridine Tetrafluoroborate (CDAP) Chemistry to Design Glycoconjugate Vaccines with Desired Structural and Immunological Characteristics by Nappini, Rebecca, Alfini, Renzo, Durante, Salvatore, Salvini, Laura, Raso, Maria Michelina, Palmieri, Elena, Di Benedetto, Roberta, Carducci, Martina, Rossi, Omar, Cescutti, Paola, Micoli, Francesca, Giannelli, Carlo

“…Glycoconjugation is a well-established technology for vaccine development: linkage of the polysaccharide (PS) antigen to an appropriate carrier protein…”
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Stability of Outer Membrane Vesicles-Based Vaccines, Identifying the Most Appropriate Methods to Detect Changes in Vaccine Potency by Palmieri, Elena, Arato, Vanessa, Oldrini, Davide, Ricchetti, Beatrice, Aruta, Maria Grazia, Pansegrau, Werner, Marchi, Sara, Giusti, Fabiola, Ferlenghi, Ilaria, Rossi, Omar, Alfini, Renzo, Giannelli, Carlo, Gasperini, Gianmarco, Necchi, Francesca, Micoli, Francesca

“…Ensuring the stability of vaccines is crucial to successfully performing global immunization programs. Outer Membrane Vesicles (OMV) are receiving great…”
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A next-generation GMMA-based vaccine candidate to fight shigellosis by Rossi, Omar, Citiulo, Francesco, Giannelli, Carlo, Cappelletti, Emilia, Gasperini, Gianmarco, Mancini, Francesca, Acquaviva, Alessandra, Raso, Maria Michelina, Sollai, Luigi, Alfini, Renzo, Aruta, Maria Grazia, Vitali, Claudia Giorgina, Pizza, Mariagrazia, Necchi, Francesca, Rappuoli, Rino, Martin, Laura B., Berlanda Scorza, Francesco, Colucci, Anna Maria, Micoli, Francesca

“…Shigellosis is a leading cause of diarrheal disease in low-middle-income countries (LMICs). Effective vaccines will help to reduce the disease burden,…”
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Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines by Oldrini, Davide, Di Benedetto, Roberta, Carducci, Martina, De Simone, Daniele, Massai, Luisa, Alfini, Renzo, Galli, Barbara, Brunelli, Brunella, Przedpelski, Amanda, Barbieri, Joseph T, Rossi, Omar, Giannelli, Carlo, Rappuoli, Rino, Berti, Francesco, Micoli, Francesca

“…Glycoconjugate vaccines play a major role in the prevention of infectious diseases worldwide, with significant impact on global health, enabling the…”
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Enhanced Systemic Humoral Immune Response Induced in Mice by Generalized Modules for Membrane Antigens (GMMA) Is Associated with Affinity Maturation and Isotype Switching by Piccioli, Diego, Buricchi, Francesca, Bacconi, Marta, Bechi, Nicoletta, Galli, Barbara, Ferlicca, Francesca, Luzzi, Enrico, Cartocci, Elena, Marchi, Sara, Romagnoli, Giacomo, Alfini, Renzo, Di Benedetto, Roberta, Gallorini, Simona, Savino, Silvana, Brunelli, Brunella, Bartolini, Erika, Micoli, Francesca

“…Generalized Modules for Membrane Antigens (GMMA) are outer membrane vesicles derived from Gram-negative bacteria that can be used to design affordable subunit…”
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Investigating the Role of Antigen Orientation on the Immune Response Elicited by Neisseria meningitidis Factor H Binding Protein on GMMA by Alfini, Renzo, Brunelli, Brunella, Bartolini, Erika, Carducci, Martina, Luzzi, Enrico, Ferlicca, Francesca, Buccato, Scilla, Galli, Barbara, Lo Surdo, Paola, Scarselli, Maria, Romagnoli, Giacomo, Cartocci, Elena, Maione, Domenico, Savino, Silvana, Necchi, Francesca, Delany, Isabel, Micoli, Francesca

“…GMMA are outer membrane vesicles (OMVs) released from Gram-negative bacteria genetically modified to enhance OMVs formation that have been shown to be optimal…”
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Relationship between antibody susceptibility and lipopolysaccharide O-antigen characteristics of invasive and gastrointestinal nontyphoidal Salmonellae isolates from Kenya by Onsare, Robert S, Micoli, Francesca, Lanzilao, Luisa, Alfini, Renzo, Okoro, Chinyere K, Muigai, Anne W, Revathi, Gunturu, Saul, Allan, Kariuki, Samuel, MacLennan, Calman A, Rondini, Simona

“…Nontyphoidal Salmonellae (NTS) cause a large burden of invasive and gastrointestinal disease among young children in sub-Saharan Africa. No vaccine is…”
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Neisseria meningitidis Factor H Binding Protein Surface Exposure on Salmonella Typhimurium GMMA Is Critical to Induce an Effective Immune Response against Both Diseases by Necchi, Francesca, Stefanetti, Giuseppe, Alfini, Renzo, Palmieri, Elena, Carducci, Martina, Di Benedetto, Roberta, Schiavo, Fabiola, Aruta, Maria Grazia, Giusti, Fabiola, Ferlenghi, Ilaria, Goh, Yun Shan, Rondini, Simona, Micoli, Francesca

“…GMMA, outer membrane vesicles resulting from hyperblebbing mutated bacterial strains, are a versatile vaccine platform for displaying both homologous and…”
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Reactivity and synthetic applications of 4,5-dicyanopyridazine: an overview by Alfini, Renzo, Cecchi, Marco, Giomi, Donatella

“…Despite the poor reputation of electron-deficient pyridazines in intermolecular Hetero Diels-Alder (HDA) reactions, 4,5-dicyanopyridazine (DCP) showed a…”
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