Search Results - "Alferiev, Ivan S"

Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation by Hood, Elizabeth D, Chorny, Michael, Greineder, Colin F, S. Alferiev, Ivan, Levy, Robert J, Muzykantov, Vladimir R

“…Abstract Endothelial-targeted delivery of antioxidant enzymes, catalase and superoxide dismutase (SOD), is a promising strategy for protecting organs and…”
Get full text

Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields by Chorny, Michael, Fishbein, Ilia, Yellen, Benjamin B, Alferiev, Ivan S, Bakay, Marina, Ganta, Srinivas, Adamo, Richard, Amiji, Mansoor, Friedman, Gary, Levy, Robert J

“…The use of stents for vascular disease has resulted in a paradigm shift with significant improvement in therapeutic outcomes. Polymer-coated drug-eluting…”
Get full text

Intraprocedural endothelial cell seeding of arterial stents via biotin/avidin targeting mitigates in-stent restenosis by Alferiev, Ivan S., Hooshdaran, Bahman, Pressly, Benjamin B., Zoltick, Philip W., Stachelek, Stanley J., Chorny, Michael, Levy, Robert J., Fishbein, Ilia

“…Impaired endothelialization of endovascular stents has been established as a major cause of in-stent restenosis and late stent thrombosis. Attempts to enhance…”
Get full text

Analysis of the Actions of RARγ Agonists on Growing Osteochondromas in a Mouse Model by Garcia, Sonia A, Wilson, Kimberly, Tang, Ningfeng, Tian, Hongying, Oichi, Takeshi, Gunawardena, Aruni T, Chorny, Michael, Alferiev, Ivan S, Herzenberg, John E, Ng, Vincent Y, Iwamoto, Masahiro, Enomoto-Iwamoto, Motomi

“…The actions of the retinoic acid nuclear receptor gamma (RARγ) agonist, palovarotene, on pre-existing osteochondromas were investigated using a mouse multiple…”
Get full text

Enhanced biocompatibility of CD47-functionalized vascular stents by Slee, Joshua B, Alferiev, Ivan S, Nagaswami, Chandrasekaran, Weisel, John W, Levy, Robert J, Fishbein, Ilia, Stachelek, Stanley J

“…Abstract The effectiveness of endovascular stents is hindered by in-stent restenosis (ISR), a secondary re-obstruction of treated arteries due to unresolved…”
Get full text

Nanocarrier-Based Delivery of SN22 as a Tocopheryl Oxamate Prodrug Achieves Rapid Tumor Regression and Extends Survival in High-Risk Neuroblastoma Models by Alferiev, Ivan S, Guerrero, David T, Soberman, Danielle, Guan, Peng, Nguyen, Ferro, Kolla, Venkatadri, Fishbein, Ilia, Pressly, Blake B, Brodeur, Garrett M, Chorny, Michael

“…Despite the use of intensive multimodality therapy, the majority of high-risk neuroblastoma (NB) patients do not survive. Without significant improvements in…”
Get full text

Stent-based delivery of AAV2 vectors encoding oxidation-resistant apoA1 by Hooshdaran, Bahman, Pressly, Benjamin B., Alferiev, Ivan S., Smith, Jonathan D., Zoltick, Philip W., Tschabrunn, Cory M., Wilensky, Robert L., Gorman, Robert C., Levy, Robert J., Fishbein, Ilia

“…In-stent restenosis (ISR) complicates revascularization in the coronary and peripheral arteries. Apolipoprotein A1 (apoA1), the principal protein component of…”
Get full text

Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma by Iyer, Radhika, Croucher, Jamie L, Chorny, Michael, Mangino, Jennifer L, Alferiev, Ivan S, Levy, Robert J, Kolla, Venkatadri, Brodeur, Garrett M

“…Highlights • We designed NPs containing a prodrug of SN38, the active metabolite of irinotecan, conjugated to tocopherol succinate.  •  Xenografts treated with…”
Get full text

Nanocarrier Design for Dual-Targeted Therapy of In-Stent Restenosis by Alferiev, Ivan S, Zhang, Kehan, Folchman-Wagner, Zoë, Adamo, Richard F, Guerrero, David T, Fishbein, Ilia, Soberman, Danielle, Levy, Robert J, Chorny, Michael

“…The injury-triggered reocclusion (restenosis) of arteries treated with angioplasty to relieve atherosclerotic obstruction remains a challenge due to…”
Get full text

Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media by Tengood, Jillian E., Alferiev, Ivan S., Zhang, Kehan, Fishbein, Ilia, Levy, Robert J., Chorny, Michael

“…The fate of nanoparticle (NP) formulations in the multifaceted biological environment is a key determinant of their biocompatibility and therapeutic…”
Get full text

Bisphosphonate-Mediated Gene Vector Delivery from the Metal Surfaces of Stents by Fishbein, Ilia, Alferiev, Ivan S., Nyanguile, Origene, Gaster, Richard, Vohs, John M., Wong, Gordon S., Felderman, Howard, Chen, I-Wei, Choi, Hoon, Wilensky, Robert L., Levy, Robert J.

“…The clinical use of metallic expandable intravascular stents has resulted in improved therapeutic outcomes for coronary artery disease. However, arterial…”
Get full text

Triglycidyl Amine Crosslinking Combined With Ethanol Inhibits Bioprosthetic Heart Valve Calcification by Connolly, Jeanne M., MS, Bakay, Marina A., PhD, Alferiev, Ivan S., PhD, Gorman, Robert C., MD, Gorman, Joseph H., MD, Kruth, Howard S., MD, Ashworth, Paul E., MS, Kutty, Jaishankar K., PhD, Schoen, Frederick J., MD, PhD, Bianco, Richard W., BA, Levy, Robert J., MD

“…Background One of the most important factors responsible for the calcific failure of bioprosthetic heart valves is glutaraldehyde crosslinking. Ethanol (EtOH)…”
Get full text

Poloxamer‐linked prodrug of a topoisomerase I inhibitor SN22 shows efficacy in models of high‐risk neuroblastoma with primary and acquired chemoresistance by Alferiev, Ivan S., Guerrero, David T., Guan, Peng, Nguyen, Ferro, Kolla, Venkatadri, Soberman, Danielle, Pressly, Benjamin B., Fishbein, Ilia, Brodeur, Garrett M., Chorny, Michael

“…High‐risk solid tumors continue to pose a tremendous therapeutic challenge due to multidrug resistance. Biological mechanisms driving chemoresistance in…”
Get full text

Hypercholesterolemia exacerbates in-stent restenosis in rabbits: Studies of the mitigating effect of stent surface modification with a CD47-derived peptide by Fishbein, Ilia, Inamdar, Vaishali V., Alferiev, Ivan S., Bratinov, George, Zviman, Menekhem M., Yekhilevsky, Anna, Nagaswami, Chandrasekaran, Gardiner, Kristin L., Levy, Robert J., Stachelek, Stanley J.

“…Hypercholesterolemia (HC) has previously been shown to augment the restenotic response in animal models and humans. However, the mechanistic aspects of…”
Get full text

Adeno-Associated Viral Vector Immobilization and Local Delivery from Bare Metal Surfaces by Pressly, Ben B, Hooshdaran, Bahman, Alferiev, Ivan S, Chorny, Michael, Levy, Robert J, Fishbein, Ilia

“…Spatially and temporally controlled delivery of biologicals, including gene vectors, represents an unmet need for regenerative medicine and gene therapy…”
Get more information

Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries by Adamo, Richard F., Fishbein, Ilia, Zhang, Kehan, Wen, Justin, Levy, Robert J., Alferiev, Ivan S., Chorny, Michael

“…Arterial injury and disruption of the endothelial layer are an inevitable consequence of interventional procedures used for treating obstructive vascular…”
Get full text

Poly-2-methyl-2-oxazoline-modified bioprosthetic heart valve leaflets have enhanced biocompatibility and resist structural degeneration by Zakharchenko, Andrey, Xue, Yingfei, Keeney, Samuel, Rock, Christopher A, Alferiev, Ivan S, Stachelek, Stanley J, Takano, Hajime, Thomas, Tina, Nagaswami, Chandrasekaran, Krieger, Abba M, Chorny, Michael, Ferrari, Giovanni, Levy, Robert J

“…Bioprosthetic heart valves (BHV) fabricated from glutaraldehyde-fixed heterograft tissue, such as bovine pericardium (BP), are widely used for treating heart…”
Get full text

Structural Optimization and Enhanced Prodrug-Mediated Delivery Overcomes Camptothecin Resistance in High-Risk Solid Tumors by Nguyen, Ferro, Guan, Peng, Guerrero, David T, Kolla, Venkatadri, Naraparaju, Koumudi, Perry, Lauren M, Soberman, Danielle, Pressly, Benjamin B, Alferiev, Ivan S, Chorny, Michael, Brodeur, Garrett M

“…Camptothecins are potent topoisomerase I inhibitors used to treat high-risk pediatric solid tumors, but they often show poor efficacy due to intrinsic or…”
Get full text

Robust Chemical Strategy for Stably Labeling Polyester-Based Nanoparticles with BODIPY Fluorophores by Alferiev, Ivan S, Fishbein, Ilia, Levy, Robert J, Chorny, Michael

“…Aliphatic polyesters are among materials most extensively used for producing biodegradable polymeric nanoparticles currently in development as delivery…”
Get full text

Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy by Alferiev, Ivan S, Iyer, Radhika, Croucher, Jamie L, Adamo, Richard F, Zhang, Kehan, Mangino, Jennifer L, Kolla, Venkatadri, Fishbein, Ilia, Brodeur, Garrett M, Levy, Robert J, Chorny, Michael

“…Abstract Nanomedicine-based strategies have the potential to improve therapeutic performance of a wide range of anticancer agents. However, the successful…”
Get full text