Search Results - "Alfayomy, Abdallah M."

Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells by Kansy, Anita G., Ashry, Ramy, Mustafa, Al‐Hassan M., Alfayomy, Abdallah M., Radsak, Markus P., Zeyn, Yanira, Bros, Matthias, Sippl, Wolfgang, Krämer, Oliver H.

“…Mammalian cells replicate ~ 3 × 109 base pairs per cell cycle. One of the key molecules that slows down the cell cycle and prevents excessive DNA damage upon…”
Get full text

A Novel Approach for the Availability and Ocular Delivery of Tenoxicam Potassium: Synthesis, Characterization, and In Vivo Application by Osman, Shaaban K., Yassin, Taher M., Mohammed, Ahmed M., Alfayomy, Abdallah M., Abdellatif, Ahmed A., Mahdi, Wael A., Alshehri, Sultan, Hamd, Mohamed A. El, Sarhan, Hatem, Ibrahim, Mohammed A.

“…Tenoxicam (TX) is a non-steroidal anti-inflammatory agent that can be used to control pain in various ophthalmic lesions like cataracts, refractive surgery,…”
Get full text

Design, synthesis and anticancer activity of new monastrol analogues bearing 1,3,4-oxadiazole moiety by Ragab, Fatma A.F., Abou-Seri, Sahar M., Abdel-Aziz, Salah A., Alfayomy, Abdallah M., Aboelmagd, Mohamed

“…A series of dihydropyrimidine (DHPM) derivatives bearing 1,3,4-oxadiazole moiety was designed and synthesized as monastrol analogues. The new compounds were…”
Get full text

Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the ataxia telangiectasia and RAD3-related (ATR) kinase by Alfayomy, Abdallah M., Ashry, Ramy, Kansy, Anita G., Sarnow, Anne-Christin, Erdmann, Frank, Schmidt, Matthias, Krämer, Oliver H., Sippl, Wolfgang

“…The Ataxia telangiectasia and RAD3-related (ATR) kinase is a key regulator of DNA replication stress responses and DNA-damage checkpoints. Several potent and…”
Get full text

Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2 inhibitors: Anti-inflammatory activity, ulcerogenic liability, histopathological and docking studies by Alfayomy, Abdallah M., Abdel-Aziz, Salah A., Marzouk, Adel A., Shaykoon, Montaser Sh. A., Narumi, Atsushi, Konno, Hiroyuki, Abou-Seri, Sahar M., Ragab, Fatma A.F.

“…[Display omitted] •Pyrimidine-5-carbonitrile hybrids were designed and synthesized as COX-2 inhibitors.•All compounds were in vitro evaluated for their…”
Get full text

Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-chlorophenyl)-3-{[(4-chlorophenyl)formamido]imino}-7-methyl-2H,3H,5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate by Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Abdallah M. Alfayomy, Sahar M. Abou Seri, Shaban A. A. Abdel-Raheem, Mokhtar A. Abd Ul-Malik

“…In the title molecule, C23H20Cl2N4O3S, the thiazole ring is planar while the pyrimidine unit fused to it adopts a screw-boat conformation. In the crystal,…”
Get full text

Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-fluorophenyl)3-{[(4-methoxyphenyl)formamido]imino}-7-methyl-2H,3H,5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate 0.25-hydrate by Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Abdallah M. Alfayomy, Fatma A. F. Ragab, Mokhtar A. Abd ul-Malik

“…In the title compound, C24H23FN4O4S·0.25H2O, the dihydropyrimidine ring is distinctly non-planar, with the flap C atom deviating by 0.297 (2) Å from the…”
Get full text

Insights into the crystal structure and computational studies of newly synthesized thiazolopyrimidine derivatives against adenosine receptor (Thermostabilised HUMAN A2a) by Mohamed, Shaaban K., El Bakri, Youness, Alfayomy, Abdallah M., Karthikeyan, Subramani, Saravanan, Kandasamy, Abdel-Aziz, Salah A., Abou-Seri, Sahar M., Ragab, Fatma A.F., Mague, Joel T., Aboelmagd, Mohamed

“…•A new tetrahydroisoquinoline derivatives were synthesized.•X-ray diffraction, FT-IR, and NMR were applied to solve the molecular structure.•DFT calculations…”
Get full text

Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-fluoro-phen-yl)3-{(4-meth-oxy-phen-yl)formamido-imino}-7-methyl-2H,3H,5H-1,3thia-zolo3,2-apyrimidine-6-carboxyl-ate 0.25-hydrate by Mohamed, Shaaban K, Mague, Joel T, Akkurt, Mehmet, Alfayomy, Abdallah M, Ragab, Fatma A F, Abd Ul-Malik, Mokhtar A

“…In the title compound, C24H23FN4O4S·0.25H2O, the di-hydro-pyrimidine ring is distinctly non-planar, with the flap C atom deviating by 0.297 (2) Å from the…”
Get full text

Crystal structure and Hirshfeld surface analysis of ethyl (3 E )-5-(4-fluorophenyl)3-{[(4-methoxyphenyl)formamido]imino}-7-methyl-2 H ,3 H ,5 H -[1,3]thiazolo[3,2- a ]pyrimidine-6-carboxylate 0.25-hydrate by Mohamed, Shaaban K., Mague, Joel T., Akkurt, Mehmet, Alfayomy, Abdallah M., Ragab, Fatma A. F., Abd ul-Malik, Mokhtar A.

“…In the title compound, C 24 H 23 FN 4 O 4 S·0.25H 2 O, the dihydropyrimidine ring is distinctly non-planar, with the flap C atom deviating by 0.297 (2) Å from…”
Get full text

Crystal structure and Hirshfeld surface analysis of ethyl (3 E )-5-(4-fluoro-phen-yl)3-{[(4-meth-oxy-phen-yl)formamido]-imino}-7-methyl-2 H ,3 H ,5 H -[1,3]thia-zolo[3,2- a ]pyrimidine-6-carboxyl-ate 0.25-hydrate by Mohamed, Shaaban K, Mague, Joel T, Akkurt, Mehmet, Alfayomy, Abdallah M, Ragab, Fatma A F, Abd Ul-Malik, Mokhtar A

“…In the title compound, C H FN O S·0.25H O, the di-hydro-pyrimidine ring is distinctly non-planar, with the flap C atom deviating by 0.297 (2) Å from the…”
Get full text

Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-fluoro­phen­yl)3-{[(4-meth­oxy­phen­yl)formamido]­imino}-7-methyl-2H,3H,5H-[1,3]thia­zolo[3,2-a]pyrimidine-6-carboxyl­ate 0.25-hydrate by Mohamed, Shaaban K., Mague, Joel T., Akkurt, Mehmet, Alfayomy, Abdallah M., Ragab, Fatma A. F., Abd ul-Malik, Mokhtar A.

“…The di­hydro­pyrimidine ring in the title mol­ecule is distinctly non-planar. In the crystal, zigzag chains parallel to [010] are formed by N—H⋯N hydrogen…”
Get full text

Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-chloro-phen-yl)-3-{(4-chloro-phen-yl)formamido-imino}-7-methyl-2H,3H,5H-1,3thia-zolo3,2-apyrimidine-6-carboxyl-ate by Mohamed, Shaaban K, Mague, Joel T, Akkurt, Mehmet, Alfayomy, Abdallah M, Seri, Sahar M Abou, Abdel-Raheem, Shaban A A, Ul-Malik, Mokhtar A Abd

“…In the title mol-ecule, C23H20Cl2N4O3S, the thia-zole ring is planar while the pyrimidine unit fused to it adopts a screw-boat conformation. In the crystal,…”
Get full text

Crystal structure and Hirshfeld surface analysis of ethyl (3 E )-5-(4-chlorophenyl)-3-{[(4-chlorophenyl)formamido]imino}-7-methyl-2 H ,3 H ,5 H -[1,3]thiazolo[3,2- a ]pyrimidine-6-carboxylate by Mohamed, Shaaban K., Mague, Joel T., Akkurt, Mehmet, Alfayomy, Abdallah M., Seri, Sahar M. Abou, Abdel-Raheem, Shaban A. A., Ul-Malik, Mokhtar A. Abd

“…In the title molecule, C 23 H 20 Cl 2 N 4 O 3 S, the thiazole ring is planar while the pyrimidine unit fused to it adopts a screw-boat conformation. In the…”
Get full text

Crystal structure and Hirshfeld surface analysis of ethyl (3 E )-5-(4-chloro-phen-yl)-3-{[(4-chloro-phen-yl)formamido]-imino}-7-methyl-2 H ,3 H ,5 H -[1,3]thia-zolo[3,2- a ]pyrimidine-6-carboxyl-ate by Mohamed, Shaaban K, Mague, Joel T, Akkurt, Mehmet, Alfayomy, Abdallah M, Seri, Sahar M Abou, Abdel-Raheem, Shaban A A, Ul-Malik, Mokhtar A Abd

“…In the title mol-ecule, C H Cl N O S, the thia-zole ring is planar while the pyrimidine unit fused to it adopts a screw-boat conformation. In the crystal,…”
Get full text

Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-chloro­phen­yl)-3-{[(4-chloro­phen­yl)formamido]­imino}-7-methyl-2H,3H,5H-[1,3]thia­zolo[3,2-a]pyrimidine-6-carboxyl­ate by Mohamed, Shaaban K., Mague, Joel T., Akkurt, Mehmet, Alfayomy, Abdallah M., Seri, Sahar M. Abou, Abdel-Raheem, Shaban A. A., Ul-Malik, Mokhtar A. Abd

“…The thia­zole ring is planar while the pyrimidine unit fused to it adopts a screw-boat conformation In the crystal, N—H⋯N plus C—H⋯N hydrogen bonds form…”
Get full text

A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction by Schneider, Carolin, Hilbert, Jorina, Genevaux, Franziska, Höfer, Stefanie, Krauß, Lukas, Schicktanz, Felix, Contreras, Constanza Tapia, Jansari, Shaishavi, Papargyriou, Aristeidis, Richter, Thorsten, Alfayomy, Abdallah M., Falcomatà, Chiara, Schneeweis, Christian, Orben, Felix, Öllinger, Ruppert, Wegwitz, Florian, Boshnakovska, Angela, Rehling, Peter, Müller, Denise, Ströbel, Philipp, Ellenrieder, Volker, Conradi, Lena, Hessmann, Elisabeth, Ghadimi, Michael, Grade, Marian, Wirth, Matthias, Steiger, Katja, Rad, Roland, Kuster, Bernhard, Sippl, Wolfgang, Reichert, Maximilian, Saur, Dieter, Schneider, Günter

“…Cancer cells must develop strategies to adapt to the dynamically changing stresses caused by intrinsic or extrinsic processes, or therapeutic agents. Metabolic…”
Get full text