Dendrimers: A New Race of Pharmaceutical Nanocarriers

Dendrimers: A New Race of Pharmaceutical Nanocarriers

Dendrimers are nanosized, symmetrical molecules in which a small atom or group of atoms is surrounded by the symmetric branches known as dendrons. The structure of dendrimers possesses the greatest impact on their physical and chemical properties. They grow outwards from the core-shell which further...

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Bibliographic Details
Published in:BioMed research international Vol. 2021; pp. 8844030 - 11
Main Authors: Mittal, Pooja, Saharan, Anjali, Verma, Ravinder, Altalbawy, Farag M. A., Alfaidi, Mohammed A., Batiha, Gaber El-Saber, Akter, Wahida, Gautam, Rupesh K., Uddin, Md. Sahab, Rahman, Md. Sohanur
Format: Journal Article
Language:English
Published: United States Hindawi 2021
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Aqueous solutions
Bioavailability
Biocompatibility
Biological activity
Chemical properties
Dendrimers
Drug delivery
Drug delivery systems
Drug dosages
Drugs
Health aspects
Ligands
Materials
Molecular chemistry
Monomers
Nanomedicine
Nanoparticles
Pharmaceutical research
Polymers
Review
Transdermal medication
Vehicles
India
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Summary:Dendrimers are nanosized, symmetrical molecules in which a small atom or group of atoms is surrounded by the symmetric branches known as dendrons. The structure of dendrimers possesses the greatest impact on their physical and chemical properties. They grow outwards from the core-shell which further reacts with monomers having one reactive or two dormant molecules. Dendrimers’ unique characteristics such as hyperbranching, well-defined spherical structure, and high compatibility with the biological systems are responsible for their wide range of applications including medical and biomedical areas. Particularly, the dendrimers’ three-dimensional structure can incorporate a wide variety of drugs to form biologically active drug conjugates. In this review, we focus on the synthesis, mechanism of drug encapsulations in dendrimers, and their wide applications in drug delivery.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Academic Editor: Mohammad Hassan Baig
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/8844030