Search Results - "Alexson, Stefan E.H."

Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated Control of Lipid Metabolism by Tillander, Veronika, Alexson, Stefan E.H, Cohen, David E

“…The cellular uptake of free fatty acids (FFA) is followed by esterification to coenzyme A (CoA), generating fatty acyl-CoAs that are substrates for oxidation…”
Get full text

The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism by Hunt, Mary C, Alexson, Stefan E.H

“…Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential…”
Get full text

Nudix Hydrolase 7 is an Acyl-CoA Diphosphatase Involved in Regulating Peroxisomal Coenzyme A Homeostasis by Reilly, Sarah-Jayne, Tillander, Veronika, Ofman, Rob, Alexson, Stefan E.H, Hunt, Mary C

“…Coenzyme A (CoASH) is an obligate cofactor for lipids undergoing β-oxidation in peroxisomes. Although the peroxisomal membrane appears to be impermeable to…”
Get full text

Diabetes or peroxisome proliferator-activated receptor α agonist increases mitochondrial thioesterase I activity in heart by King, Kristen L., Young, Martin E., Kerner, Janos, Huang, Hazel, O'Shea, Karen M., Alexson, Stefan E.H., Hoppel, Charles L., Stanley, William C.

“…Peroxisome proliferator-activated receptor α (PPARα) is a transcriptional regulator of the expression of mitochondrial thioesterase I (MTE-I) and uncoupling…”
Get full text

The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism by Hunt, Mary C., Siponen, Marina I., Alexson, Stefan E.H.

“…The importance of peroxisomes in lipid metabolism is now well established and peroxisomes contain approximately 60 enzymes involved in these lipid metabolic…”
Get full text

Regulation of peroxisomal lipid metabolism: The role of acyl-CoA and coenzyme A metabolizing enzymes by Hunt, Mary C., Tillander, Veronika, Alexson, Stefan E.H.

“…Peroxisomes are nearly ubiquitous organelles involved in a number of metabolic pathways that vary between organisms and tissues. A common metabolic function in…”
Get full text

Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs by Hunt, Mary C, Rautanen, Anna, Westin, Maria A.K, Svensson, L. Thomas, Alexson, Stefan E.H

“…The maintenance of cellular levels of free fatty acids and acyl-CoAs, the activated form of free fatty acids, is extremely important, as imbalances in lipid…”
Get full text

The Identification of a Succinyl-CoA Thioesterase Suggests a Novel Pathway for Succinate Production in Peroxisomes by Westin, Maria A.K., Hunt, Mary C., Alexson, Stefan E.H.

“…Dicarboxylic acids are formed by ω-oxidation of fatty acids in the endoplasmic reticulum and degraded as the CoA ester via β-oxidation in peroxisomes. Both…”
Get full text

revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases by Hunt, Mary C, Yamada, Junji, Maltais, Lois J, Wright, Mathew W, Podesta, Ernesto J, Alexson, Stefan E. H

“…Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated,…”
Get full text

Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice by Yang, Qian, Xie, Yi, Alexson, Stefan E.H., Dean Nelson, B., DePierre, Joseph W.

“…Peroxisome proliferators (PPs) are a large class of structurally diverse chemicals, which includes drugs designed to improve the metabolic abnormalities…”
Get full text

peroxisomal acyltransferase in mouse identifies a novel pathway for taurine conjugation of fatty acids by Reilly, Sarah-Jayne, O'Shea, Ethna M, Andersson, Ulla, O'Byrne, James, Alexson, Stefan E.H, Hunt, Mary C

“…A wide variety of endogenous carboxylic acids and xenobiotics are conjugated with amino acids, before excretion in urine or bile. The conjugation of carboxylic…”
Get full text

The Human Bile Acid-CoA:Amino Acid N-Acyltransferase Functions in the Conjugation of Fatty Acids to Glycine by O'Byrne, James, Hunt, Mary C., Rai, Dilip K., Saeki, Masayumi, Alexson, Stefan E.H.

“…Bile acid-CoA:amino acid N-acyltransferase (BACAT) catalyzes the conjugation of bile acids to glycine and taurine for excretion into bile. By use of…”
Get full text

Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans by Diczfalusy, M A, Björkhem, I, Einarsson, C, Hillebrant, C G, Alexson, S E

“…Elevated fatty acid ethyl ester (FAEE) concentrations have been detected in postmortem organs from alcoholics and patients acutely intoxicated by alcohol, and…”
Get full text

Differential regulation of cytosolic and peroxisomal bile acid amidation by PPARα activation favors the formation of unconjugated bile acids by Solaas, Karianne, Kase, B. Frode, Pham, Viet, Bamberg, Krister, Hunt, Mary C., Alexson, Stefan E.H.

“…In human liver, unconjugated bile acids can be formed by the action of bile acid-CoA thioesterases (BACTEs), whereas bile acid conjugation with taurine or…”
Get full text

Peroxisome Proliferator-induced Long Chain Acyl-CoA Thioesterases Comprise a Highly Conserved Novel Multi-gene Family Involved in Lipid Metabolism by Hunt, M C, Nousiainen, S E, Huttunen, M K, Orii, K E, Svensson, L T, Alexson, S E

“…Long chain acyl-CoA esters are important intermediates in degradation and synthesis of fatty acids, as well as having important functions in regulation of…”
Get full text

Pharmacological and Toxicological Advances in PPAR-Related Medicines by Kamijo, Yuji, Nicol, Christopher J. B., Alexson, Stefan E. H.

Get full text

Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases by Hunt, M C, Lindquist, P J, Peters, J M, Gonzalez, F J, Diczfalusy, U, Alexson, S E

“…Long-chain acyl-CoA thioesterases catalyze the hydrolysis of acyl-CoAs to the corresponding free fatty acid and CoA. We recently cloned four members of a novel…”
Get full text

Rat Peroxisome Proliferator-activated Receptors and Brown Adipose Tissue Function during Cold Acclimatization by Guardiola-Diaz, Hebe M., Rehnmark, Stefan, Usuda, Nobuteru, Albrektsen, Tatjana, Feltkamp, Dorothee, Gustafsson, Jan-Åke, Alexson, Stefan E.H.

“…Brown adipose tissue (BAT) hyperplasia is a fundamental physiological response to cold; it involves an acute phase of mitotic cell growth followed by a…”
Get full text

Altered expression of the carboxylesterases ES-4 and ES-10 by peroxisome proliferator chemicals by Poole, Michele, Bridgers, Kristie, Alexson, Stefan E.H., Corton, J.Christopher

“…The nonspecific carboxylesterases (EC.3.1.1.1) are a large group of enzymes that play important roles in the metabolism of foreign xenobiotics and endogenous…”
Get full text

PPARα is a key regulator of hepatic FGF21 by Lundåsen, Thomas, Hunt, Mary C., Nilsson, Lisa-Mari, Sanyal, Sabyasachi, Angelin, Bo, Alexson, Stefan E.H., Rudling, Mats

“…The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. Using quantitative RT-PCR, we…”
Get full text