Search Results - "Alexson, Stefan"

Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated Control of Lipid Metabolism by Tillander, Veronika, Alexson, Stefan E.H, Cohen, David E

“…The cellular uptake of free fatty acids (FFA) is followed by esterification to coenzyme A (CoA), generating fatty acyl-CoAs that are substrates for oxidation…”
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The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL by Lundåsen, Thomas, Pedrelli, Matteo, Bjørndal, Bodil, Rozell, Björn, Kuiper, Raoul V, Burri, Lena, Pavanello, Chiara, Turri, Marta, Skorve, Jon, Berge, Rolf K, Alexson, Stefan E H, Tillander, Veronika

“…Tetradecylthioacetic acid (TTA) is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo…”
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The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism by Hunt, Mary C., Siponen, Marina I., Alexson, Stefan E.H.

“…The importance of peroxisomes in lipid metabolism is now well established and peroxisomes contain approximately 60 enzymes involved in these lipid metabolic…”
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Regulation of peroxisomal lipid metabolism: The role of acyl-CoA and coenzyme A metabolizing enzymes by Hunt, Mary C., Tillander, Veronika, Alexson, Stefan E.H.

“…Peroxisomes are nearly ubiquitous organelles involved in a number of metabolic pathways that vary between organisms and tissues. A common metabolic function in…”
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Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria by Tillander, Veronika, Arvidsson Nordström, Elisabet, Reilly, Jenny, Strozyk, Malgorzata, Van Veldhoven, Paul P, Hunt, Mary C, Alexson, Stefan E. H

“…Acyl-CoA thioesterase (ACOT) activities are found in prokaryotes and in several compartments of eukaryotes where they hydrolyze a wide range of acyl-CoA…”
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PPARα is a key regulator of hepatic FGF21 by Lundåsen, Thomas, Hunt, Mary C., Nilsson, Lisa-Mari, Sanyal, Sabyasachi, Angelin, Bo, Alexson, Stefan E.H., Rudling, Mats

“…The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. Using quantitative RT-PCR, we…”
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The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism by Hunt, Mary C, Alexson, Stefan E.H

“…Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential…”
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Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs by Hunt, Mary C, Rautanen, Anna, Westin, Maria A.K, Svensson, L. Thomas, Alexson, Stefan E.H

“…The maintenance of cellular levels of free fatty acids and acyl-CoAs, the activated form of free fatty acids, is extremely important, as imbalances in lipid…”
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Fish oil and krill oil supplementations differentially regulate lipid catabolic and synthetic pathways in mice by Tillander, Veronika, Bjørndal, Bodil, Burri, Lena, Bohov, Pavol, Skorve, Jon, Berge, Rolf K, Alexson, Stefan EH

“…BACKGROUND: Marine derived oils are rich in long-chain polyunsaturated omega-3 fatty acids, in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid…”
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Three differently generated salmon protein hydrolysates reveal opposite effects on hepatic lipid metabolism in mice fed a high-fat diet by Vik, Rita, Tillander, Veronika, Skorve, Jon, Vihervaara, Terhi, Ekroos, Kim, Alexson, Stefan E.H., Berge, Rolf K., Bjørndal, Bodil

“…•Salmon hydrolysates generated using different methods were fed to mice for 6weeks.•The 3 hydrolysates had different effects on body weight compared to a…”
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The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism by Harijan, Rajesh K., Mazet, Muriel, Kiema, Tiila R., Bouyssou, Guillaume, Alexson, Stefan E. H., Bergmann, Ulrich, Moreau, Patrick, Michels, Paul A. M., Bringaud, Frédéric, Wierenga, Rik K.

“…ABSTRACT Bioinformatics studies have shown that the genomes of trypanosomatid species each encode one SCP2‐thiolase‐like protein (SLP), which is characterized…”
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Fish oil and krill oil differentially modify the liver and brain lipidome when fed to mice by Skorve, Jon, Hilvo, Mika, Vihervaara, Terhi, Burri, Lena, Bohov, Pavol, Tillander, Veronika, Bjørndal, Bodil, Suoniemi, Matti, Laaksonen, Reijo, Ekroos, Kim, Berge, Rolf K, Alexson, Stefan E H

“…Marine food is an important source of omega-3 fatty acids with beneficial health effects. Oils from marine organisms have different fatty acid composition and…”
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Nudix Hydrolase 7 is an Acyl-CoA Diphosphatase Involved in Regulating Peroxisomal Coenzyme A Homeostasis by Reilly, Sarah-Jayne, Tillander, Veronika, Ofman, Rob, Alexson, Stefan E.H, Hunt, Mary C

“…Coenzyme A (CoASH) is an obligate cofactor for lipids undergoing β-oxidation in peroxisomes. Although the peroxisomal membrane appears to be impermeable to…”
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Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism by Hunt, Mary C., Alexson, Stefan E.H.

“…Peroxisomes are single membrane bound organelles present in almost all eukaryotic cells, and to date have been shown to contain approximately 60 identified…”
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The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities by Kiema, Tiila-Riikka, Harijan, Rajesh K., Strozyk, Malgorzata, Fukao, Toshiyuki, Alexson, Stefan E. H., Wierenga, Rik K.

“…Crystal structures of human mitochondrial 3‐ketoacyl‐CoA thiolase (hT1) in the apo form and in complex with CoA have been determined at 2.0 Å resolution. The…”
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The Identification of a Succinyl-CoA Thioesterase Suggests a Novel Pathway for Succinate Production in Peroxisomes by Westin, Maria A.K., Hunt, Mary C., Alexson, Stefan E.H.

“…Dicarboxylic acids are formed by ω-oxidation of fatty acids in the endoplasmic reticulum and degraded as the CoA ester via β-oxidation in peroxisomes. Both…”
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Diabetes or peroxisome proliferator-activated receptor α agonist increases mitochondrial thioesterase I activity in heart by King, Kristen L., Young, Martin E., Kerner, Janos, Huang, Hazel, O'Shea, Karen M., Alexson, Stefan E.H., Hoppel, Charles L., Stanley, William C.

“…Peroxisome proliferator-activated receptor α (PPARα) is a transcriptional regulator of the expression of mitochondrial thioesterase I (MTE-I) and uncoupling…”
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revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases by Hunt, Mary C, Yamada, Junji, Maltais, Lois J, Wright, Mathew W, Podesta, Ernesto J, Alexson, Stefan E. H

“…Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated,…”
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Involvement of the peroxisome proliferator-activated receptor alpha in the immunomodulation caused by peroxisome proliferators in mice by Yang, Qian, Xie, Yi, Alexson, Stefan E.H., Dean Nelson, B., DePierre, Joseph W.

“…Peroxisome proliferators (PPs) are a large class of structurally diverse chemicals, which includes drugs designed to improve the metabolic abnormalities…”
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peroxisomal acyltransferase in mouse identifies a novel pathway for taurine conjugation of fatty acids by Reilly, Sarah-Jayne, O'Shea, Ethna M, Andersson, Ulla, O'Byrne, James, Alexson, Stefan E.H, Hunt, Mary C

“…A wide variety of endogenous carboxylic acids and xenobiotics are conjugated with amino acids, before excretion in urine or bile. The conjugation of carboxylic…”
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