Search Results - "Alexopoulos, LG"

A Deep Learning Framework for Predicting Response to Therapy in Cancer by Sakellaropoulos, Theodore, Vougas, Konstantinos, Narang, Sonali, Koinis, Filippos, Kotsinas, Athanassios, Polyzos, Alexander, Moss, Tyler J., Piha-Paul, Sarina, Zhou, Hua, Kardala, Eleni, Damianidou, Eleni, Alexopoulos, Leonidas G., Aifantis, Iannis, Townsend, Paul A., Panayiotidis, Mihalis I., Sfikakis, Petros, Bartek, Jiri, Fitzgerald, Rebecca C., Thanos, Dimitris, Mills Shaw, Kenna R., Petty, Russell, Tsirigos, Aristotelis, Gorgoulis, Vassilis G.

“…A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a personalized basis. Using a pharmacogenomics database of 1,001…”
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MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis by Kotelnikova, Ekaterina, Kiani, Narsis A., Messinis, Dimitris, Pertsovskaya, Inna, Pliaka, Vicky, Bernardo-Faura, Marti, Rinas, Melanie, Vila, Gemma, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Sakellaropoulos, Theodore, Faigle, Wolfgang, Silberberg, Gilad, Masso, Mar, Stridh, Pernilla, Behrens, Janina, Olsson, Tomas, Martin, Roland, Paul, Friedemann, Alexopoulos, Leonidas G., Saez-Rodriguez, Julio, Tegner, Jesper, Villoslada, Pablo

“…Dysregulation of signaling pathways in multiple sclerosis (MS) can be analyzed by phosphoproteomics in peripheral blood mononuclear cells (PBMCs). We performed…”
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Dynamics and heterogeneity of brain damage in multiple sclerosis by Kotelnikova, Ekaterina, Kiani, Narsis A, Abad, Elena, Martinez-Lapiscina, Elena H, Andorra, Magi, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Pertsovskaya, Inna, Alexopoulos, Leonidas G, Olsson, Tomas, Martin, Roland, Paul, Friedemann, Tegnér, Jesper, Garcia-Ojalvo, Jordi, Villoslada, Pablo

“…Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative processes that damage the central nervous system (CNS). However, it is…”
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Micro-bead immunoassays for the detection of IL6 and PDGF-2 proteins on a microfluidic platform, incorporating superhydrophobic passive valves by Ellinas, K., Pliaka, V., Kanakaris, G., Tserepi, A., Alexopoulos, L.G., Gogolides, E.

“…A microfluidic platform optimized for bead-based immunoassays is presented. It uses a simple design that incorporates passive valves in the inlet and outlet of…”
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Determination of the Poisson's ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration by Trickey, Wendy R., Baaijens, Frank P.T., Laursen, Tod A., Alexopoulos, Leonidas G., Guilak, Farshid

“…Chondrocytes in articular cartilage are regularly subjected to compression and recovery due to dynamic loading of the joint. Previous studies have investigated…”
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The biomechanical role of the chondrocyte pericellular matrix in articular cartilage by Alexopoulos, Leonidas G., Setton, Lori A., Guilak, Farshid

“…The pericellular matrix (PCM) is a narrow tissue region that surrounds chondrocytes in articular cartilage. Previous parametric studies of cell–matrix…”
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Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis by Bernardo-Faura, Marti, Rinas, Melanie, Wirbel, Jakob, Pertsovskaya, Inna, Pliaka, Vicky, Messinis, Dimitris E, Vila, Gemma, Sakellaropoulos, Theodore, Faigle, Wolfgang, Stridh, Pernilla, Behrens, Janina R, Olsson, Tomas, Martin, Roland, Paul, Friedemann, Alexopoulos, Leonidas G, Villoslada, Pablo, Saez-Rodriguez, Julio

“…Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system…”
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Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage by Alexopoulos, Leonidas G., Williams, Gregory M., Upton, Maureen L., Setton, Lori A., Guilak, Farshid

“…The pericellular matrix (PCM) is a narrow region of cartilaginous tissue that surrounds chondrocytes in articular cartilage. Previous modeling studies indicate…”
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Signaling networks in MS: A systems-based approach to developing new pharmacological therapies by Kotelnikova, Ekaterina, Bernardo-Faura, Marti, Silberberg, Gilad, Kiani, Narsis A, Messinis, Dimitris, Melas, Ioannis N, Artigas, Laura, Schwartz, Elena, Mazo, Ilya, Masso, Mar, Alexopoulos, Leonidas G, Mas, Jose Manuel, Olsson, Tomas, Tegner, Jesper, Martin, Roland, Zamora, Albert, Paul, Friedemann, Saez-Rodriguez, Julio, Villoslada, Pablo

“…The pathogenesis of multiple sclerosis (MS) involves alterations to multiple pathways and processes, which represent a significant challenge for developing…”
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A Functional Landscape of CKD Entities From Public Transcriptomic Data by Tajti, Ferenc, Kuppe, Christoph, Antoranz, Asier, Ibrahim, Mahmoud M., Kim, Hyojin, Ceccarelli, Francesco, Holland, Christian H., Olauson, Hannes, Floege, Jürgen, Alexopoulos, Leonidas G., Kramann, Rafael, Saez-Rodriguez, Julio

“…To develop effective therapies and identify novel early biomarkers for chronic kidney disease, an understanding of the molecular mechanisms orchestrating it is…”
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Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis by Alexopoulos, Leonidas G, Haider, Mansoor A, Vail, Thomas P, Guilak, Farshid

“…In articular cartilage, chondrocytes are surrounded by a pericellular matrix (PCM), which together with the chondrocyte have been termed the "chondron." While…”
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Zonal uniformity in mechanical properties of the chondrocyte pericellular matrix: micropipette aspiration of canine chondrons isolated by cartilage homogenization by Guilak, Farshid, Alexopoulos, Leonidas G, Haider, Mansoor A, Ting-Beall, H Ping, Setton, Lori A

“…The pericellular matrix (PCM) is a region of tissue that surrounds chondrocytes in articular cartilage and together with the enclosed cells is termed the…”
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Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways by Erickson, Geoffrey R, Alexopoulos, Leonidas G, Guilak, Farshid

“…Mechanical compression of cartilage is associated with a rise in the interstitial osmotic pressure, which can alter cell volume and activate volume recovery…”
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Network-Based Analysis of Nutraceuticals in Human Hepatocellular Carcinomas Reveals Mechanisms of Chemopreventive Action: A Systems Approach to Liver Cancer Chemoprevention by Michailidou, M, Melas, IN, Messinis, DE, Klamt, S, Alexopoulos, LG, Kolisis, FN, Loutrari, H

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Network‐Based Analysis of Nutraceuticals in Human Hepatocellular Carcinomas Reveals Mechanisms of Chemopreventive Action by Michailidou, M, Melas, IN, Messinis, DE, Klamt, S, Alexopoulos, LG, Kolisis, FN, Loutrari, H

“…Chronic inflammation is associated with the development of human hepatocellular carcinoma (HCC), an essentially incurable cancer. Anti‐inflammatory…”
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A method for quantifying cell size from differential interference contrast images: validation and application to osmotically stressed chondrocytes by Alexopoulos, L. G., Erickson, G. R., Guilak, F.

“…Summary An automatic image analysis method was developed to determine the shape and size of spheroidal cells from a time series of differential interference…”
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