Search Results - "Alexis, N E"

Extracellular purines are biomarkers of neutrophilic airway inflammation by Esther, C. R., Jr, Alexis, N. E, Clas, M. L, Lazarowski, E. R, Donaldson, S. H, Pedrosa Ribeiro, C. M, Moore, C. G, Davis, S. D, Boucher, R. C

“…Purinergic signalling regulates airway defence mechanisms, suggesting that extracellular purines could serve as airway inflammation biomarkers in cystic…”
Get full text

Effect of inhaled dust mite allergen on regional particle deposition and mucociliary clearance in allergic asthmatics by Bennett, W. D., Herbst, M., Alexis, N. E., Zeman, K. L., Wu, J., Hernandez, M. L., Peden, D. B.

“…Summary Background Acute exacerbations in allergic asthmatics may lead to impaired ability to clear mucus from the airways, a key factor in asthma morbidity…”
Get full text

In vivo uptake of inhaled particles by airway phagocytes is enhanced in patients with mild asthma compared with normal volunteers by Lay, J C, Alexis, N E, Zeman, K L, Peden, D B, Bennett, W D

“…The uptake of inhaled particulate matter by airway phagocytes is an important defence mechanism contributing to the clearance of potentially toxic substances,…”
Get more information

Effects of short-term increases in personal and ambient pollutant concentrations on pulmonary and cardiovascular function: A panel study analysis of the Multicenter Ozone Study in oldEr subjects (MOSES 2) by Frampton, M.W., Balmes, J.R., Bromberg, P.A., Arjomandi, M., Hazucha, M.J., Thurston, S.W., Alexis, N.E., Ganz, P., Zareba, W., Koutrakis, P., Thevenet-Morrison, K., Rich, D.Q.

“…The cardiovascular effects of ozone exposure are unclear. Using measurements from the 87 participants in the Multicenter Ozone Study of oldEr Subjects (MOSES),…”
Get full text

Inflammation in induced sputum after aluminium oxide exposure: an experimental chamber study by Sikkeland, LIB, Alexis, N E, Fry, RC, Martin, E, Danielsen, TE, Søstrand, P, Kongerud, J

“…IntroductionWorkers in aluminium production are exposed to a complex mixture of particles and gases potentially harmful to the airways, among them aluminium…”
Get full text

Intracisternal basic fibroblast growth factor (bFGF) enhances behavioral recovery following focal cerebral infarction in the rat by Kawamata, T, Alexis, N E, Dietrich, W D, Finklestein, S P

“…Basic fibroblast growth factor (bFGF) is a potent neurotrophic agent that promotes neuronal survival and outgrowth. Previous studies have shown that bFGF,…”
Get more information

Neurobehavioral consequences of induced spreading depression following photothrombotic middle cerebral artery occlusion by Alexis, N.E., Back, T., Zhao, W., Dietrich, W.D., Watson, B.D., Ginsberg, M.D.

“…In a model of experimental focal cerebral ischemia, we have recently reported a strong correlation between the magnitude of ischemic depolarizations in the…”
Get full text

Induced Sputum Derives from the Central Airways . Confirmation Using a Radiolabeled Aerosol Bolus Delivery Technique by ALEXIS, NEIL E, HU, SHU-CHIEH, ZEMAN, KIRBY, ALTER, TODD, BENNETT, WILLIAM D

“…Indirect evidence suggests that induced sputum derives from the surfaces of the bronchial airways. To confirm this experimentally, we employed a radiolabeled…”
Get full text

Association between airway hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma by Alexis, N E, Soukup, J, Nierkens, S, Becker, S

“…Little is known about the functional capabilities of bronchial macrophages (BMs) and their relationship to airway disease such as asthma. We hypothesize that…”
Get more information

Acute LPS inhalation in healthy volunteers induces dendritic cell maturation in vivo by Alexis, Neil E., Lay, John C., Almond, Martha, Bromberg, Philip A., Patel, Dhavalkumar D., Peden, David B.

“…We have been studying the innate immune response of airways cells of healthy human volunteers to inhaled LPS, a Toll-like receptor 4 (TLR4) ligand, and have…”
Get full text

Low-dose airborne endotoxin exposure enhances bronchial responsiveness to inhaled allergen in atopic asthmatics by Boehlecke, Brian, Hazucha, Milan, Alexis, Neil E., Jacobs, Robert, Reist, Parker, Bromberg, Philip A., Peden, David B.

“…To the Editor: Endotoxin exposure has been associated with both protection against development of TH2-immune responses during childhood and exacerbation of…”
Get full text

Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects by Alexis, Neil E., Eldridge, Marlowe W., Peden, David B.

“…Background: In a cohort of 8 normal and 10 allergic asthmatic volunteers, we previously reported that inhalation of 5 μg of endotoxin (LPS) induced airway…”
Get full text

Blunting airway eosinophilic inflammation results in a decreased airway neutrophil response to inhaled LPS in patients with atopic asthma: A role for CD14 by Alexis, Neil E., Peden, David B.

“…Recent data demonstrate that atopic inflammation might enhance airway responses to inhaled LPS in individuals with atopic asthma by increasing CD14 expression…”
Get full text

Circulating CD11b expression correlates with the neutrophil response and airway mCD14 expression is enhanced following ozone exposure in humans by Alexis, Neil E, Becker, Suzanne, Bromberg, Philip A, Devlin, Robert, Peden, David B

“…We recently reported that baseline expression of circulating CD11b is associated with the magnitude of the neutrophil response following inhaled endotoxin. In…”
Get full text

A32 ASTHMA AND ALLERGY CLINICAL STUDIES: Stability Of Baseline Measures Of Sputum Cell Counts In Healthy Individuals Over 12 Months: Practical Implications For Study Design by Alexis, N E, Zhou, Q, Peden, D, Zhou, H

“…Study design decisions however, require information on the stability of key baseline sputum measures over longer time periods. [...]we analyzed cell count data…”
Get full text

A26 SMOKE, POLLUTANTS, AND TOXINS: INSIGHTS FROM BENCH STUDIES: The Impact Of New And Emerging Tobacco Products On The Airway Mucosal Barrier by Reidel, B, Radicioni, G, d, A A, Haridass, P, Alexis, N E, Jaspers, I, Kesimer, M

Get full text

C22 AIRWAY EPITHELIUM: MOLECULAR REGULATION OF INFLAMMATION: Splunc1 Modulates Calcium Influx In Airway Smooth Muscle by Wu, T, Walton, W, Redinbo, M, Alexis, N E, Tarran, R

Get full text

B101 PHENOTYPING OF ASTHMA IN THE ERA OF BIOMARKERS AND OMICS: M1 M2 Sputum Macrophage Profiles In Healthy Individuals, Airway Disease, Tobacco Smokers And Alternative Tobacco Users by Alexis, N E, Wells, H B, Miller, S, Goldstein, B, Saini, Y, Donaldson, S, Peden, D

Get full text

A16 WHY SHOULD WE BE CONCERNED ABOUT E-CIGARETTES?: E-Cigarette User Airway Secretions Exhibit Increased Leukocyte Derived Inflammatory Mediator Proteins by Reidel, B, d, A A, Radicioni, G, Haridass, P, Alexis, N E, Jaspers, I, Tarran, R, Kesimer, M

“…Corresponding author's email: boris_reidel@med.unc.edu Rationale: Although the detrimental effects of cigarette smoking on lung health have been thoroughly…”
Get full text

IRON-BINDING AND STORAGE PROTEINS IN SPUTUM by Alexis, Neil E., Richards, Judy H., Carter, Jacqueline D., Ghio, Andrew J.

“…Induced sputum (IS) and bronchoalveolar lavage (BAL) sample different lung compartments, with IS obtaining secretions from the surfaces of the bronchial…”
Get full text