Search Results - "Alexis, Michael N."

Natural and Nature-Derived Products Targeting Human Coronaviruses by Vougogiannopoulou, Konstantina, Corona, Angela, Tramontano, Enzo, Alexis, Michael N, Skaltsounis, Alexios-Leandros

“…The ongoing pandemic of severe acute respiratory syndrome (SARS), caused by the SARS-CoV-2 human coronavirus (HCoV), has brought the international scientific…”
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Perinatal exposure to low-dose bisphenol A affects the neuroendocrine stress response in rats by Panagiotidou, Emily, Zerva, Sophia, Mitsiou, Dimitra J, Alexis, Michael N, Kitraki, Efthymia

“…Bisphenol A (BPA) is an estrogen-mimicking endocrine disruptor. Early-life exposures to low doses of BPA exert long-lasting effects on animals' reproductive…”
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ERβ1 Sensitizes and ERβ2 Desensitizes ERα-Positive Breast Cancer Cells to the Inhibitory Effects of Tamoxifen, Fulvestrant and Their Combination with All-Trans Retinoic Acid by Meligova, Aggeliki K, Siakouli, Dimitra, Stasinopoulou, Sotiria, Xenopoulou, Despoina S, Zoumpouli, Maria, Ganou, Vassiliki, Gkotsi, Eleni-Fani, Chatziioannou, Aristotelis, Papadodima, Olga, Pilalis, Eleftherios, Alexis, Michael N, Mitsiou, Dimitra J

“…Adjuvant endocrine therapy (AET) is the treatment of choice for early-stage estrogen receptor alpha (ERα)-positive breast cancer (BC). However, almost 40% of…”
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Biological evaluation of isoflavonoids from Genista halacsyi using estrogen-target cells: Activities of glucosides compared to aglycones by Fokialakis, Nikolas, Alexi, Xanthippi, Aligiannis, Nektarios, Boulaka, Athina, Meligova, Aggeliki K, Lambrinidis, George, Kalpoutzakis, Eleftherios, Pratsinis, Harris, Cheilari, Antigoni, Mitsiou, Dimitra J, Mitakou, Sofia, Alexis, Michael N

“…The purpose of this study was to evaluate the response of estrogen target cells to a series of isoflavone glucosides and aglycones from Genista halacsyi Heldr…”
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Isoflavonoid Profiling and Estrogen-Like Activity of Four Genista Species from the Greek Flora by Cheilari, Antigoni, Vontzalidou, Argyro, Makropoulou, Maria, Meligova, Aggeliki K, Fokialakis, Nikolas, Mitakou, Sofia, Alexis, Michael N, Aligiannis, Nektarios

“…As part of our ongoing research on phytoestrogens, we investigated the phytochemical profile and estrogen-like activities of eight extracts from the aerial…”
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Biological and computational evaluation of resveratrol inhibitors against Alzheimer's disease by Koukoulitsa, Catherine, Villalonga-Barber, Caroline, Csonka, Robert, Alexi, Xanthippi, Leonis, Georgios, Dellis, Dimitris, Hamelink, Elizabeth, Belda, Oscar, Steele, Barry R, Micha-Screttas, Maria, Alexis, Michael N, Papadopoulos, Manthos G, Mavromoustakos, Thomas

“…It has been reported that beta amyloid induces production of radical oxygen species and oxidative stress in neuronal cells, which in turn upregulates…”
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Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835] by Apostolopoulos, Vasso, Pietersz, Geoffrey A, Tsibanis, Anastasios, Tsikkinis, Annivas, Drakaki, Heleni, Loveland, Bruce E, Piddlesden, Sara J, Plebanski, Magdalena, Pouniotis, Dodie S, Alexis, Michael N, McKenzie, Ian F, Vassilaros, Stamatis

“…Mucin 1 (MUC1) is a high molecular weight glycoprotein overexpressed on adenocarcinoma cells and is a target for immunotherapy protocols. To date, clinical…”
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Estrogen receptor α and β in uterine fibroids: a basis for altered estrogen responsiveness by Bakas, Panagiotis, M.D, Liapis, Angelos, M.D, Vlahopoulos, Spiros, Ph.D, Giner, Maria, M.D, Logotheti, Stella, B.Sc, Creatsas, Georgios, M.D, Meligova, Aggeliki K., B.Sc, Alexis, Michael N., Ph.D, Zoumpourlis, Vassilis, Ph.D

“…Objective To investigate the relative expression and the DNA-binding status of estrogen receptors α and β in fibroids and normal myometrial tissue to explore…”
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Pharmacoproteomic Study of the Natural Product Ebenfuran III in DU-145 Prostate Cancer Cells: The Quantitative and Temporal Interrogation of Chemically Induced Cell Death at the Protein Level by Roumeliotis, Theodoros I, Halabalaki, Maria, Alexi, Xanthippi, Ankrett, Dyan, Giannopoulou, Eugenia G, Skaltsounis, Alexios-Leandros, Sayan, Berna S, Alexis, Michael N, Townsend, Paul A, Garbis, Spiros D

“…A naturally occurring benzofuran derivative, Ebenfuran III (Eb III), was investigated for its antiproliferative effects using the DU-145 prostate cell line. Eb…”
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Cytotoxic effects of 2-arylbenzofuran phytoestrogens on human cancer cells: Modulation by adrenal and gonadal steroids by Katsanou, Efrosini S., Halabalaki, Maria, Aligiannis, Nektarios, Mitakou, Sofia, Skaltsounis, Alexios-Leandros, Alexi, Xanthippi, Pratsinis, Harris, Alexis, Michael N.

“…Although 2-arylbenzofuran phytoalexins are known for decades, their anticancer activity has not been studied systematically. We have previously reported on the…”
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Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes by Rao, Nagesha A S, McCalman, Melysia T, Moulos, Panagiotis, Francoijs, Kees-Jan, Chatziioannou, Aristotelis, Kolisis, Fragiskos N, Alexis, Michael N, Mitsiou, Dimitra J, Stunnenberg, Hendrik G

“…Glucocorticoid receptor (GR) exerts anti-inflammatory action in part by antagonizing proinflammatory transcription factors such as the nuclear factor kappa-b…”
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Microarray analysis of the differential transformation mediated by Kirsten and Harvey Ras oncogenes in a human colorectal adenocarcinoma cell line by Roberts, Michael L., Drosopoulos, Konstantinos G., Vasileiou, Ioannis, Stricker, Mona, Taoufik, Era, Maercker, Christian, Guialis, Apostolia, Alexis, Michael N., Pintzas, Alexander

“…Colorectal cancer arises after a series of mutational events in the colon epithelia and is often used as a model of the multistep progression of tumorigenesis…”
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Discovery of New non-steroidal selective glucocorticoid receptor agonists by Potamitis, Constantinos, Siakouli, Dimitra, Papavasileiou, Konstantinos D., Boulaka, Athina, Ganou, Vassiliki, Roussaki, Marina, Calogeropoulou, Theodora, Zoumpoulakis, Panagiotis, Alexis, Michael N., Zervou, Maria, Mitsiou, Dimitra J.

“…[Display omitted] •Virtual Screening utilizing a structure-based pharmacophore model of GR-LBD.•Discovery of two 1,3-benzothiazole analogs (1 and 13) acting as…”
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The brominated flame retardants TBECH and DPTE alter prostate growth, histology and gene expression patterns in the mouse by Bereketoglu, Ceyhun, Modig, Carina, Pradhan, Ajay, Andersson, Patrik L., Stasinopoulou, Sotiria, Mitsiou, Dimitra J., Alexis, Michael N., Olsson, Per-Erik

“…•The brominated flame retardants TBECH and DPTE are potential endocrine disrupters.•TBECHγδ and DPTE display high androgen receptor agonist and antagonist…”
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Design, synthesis, and biological evaluation of new raloxifene analogues of improved antagonist activity and endometrial safety by Lambrinidis, George, Gouedard, Cedric, Stasinopoulou, Sotiria, Angelopoulou, Angeliki, Ganou, Vassiliki, Meligova, Aggeliki K., Mitsiou, Dimitra J., Marakos, Panagiotis, Pouli, Nicole, Mikros, Emmanuel, Alexis, Michael N.

“…[Display omitted] •Rational design, synthesis and evaluation of 14 basic side chain (BSC) analogues of raloxifene.•The analogues’ BSC bore a polar group in the…”
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Phytochemical study and biological evaluation of chemical constituents of Platanus orientalis and Platanus × acerifolia buds by Thai, Quoc Dang, Tchoumtchoua, Job, Makropoulou, Maria, Boulaka, Athina, Meligova, Aggeliki K., Mitsiou, Dimitra J., Mitakou, Sophia, Michel, Sylvie, Halabalaki, Maria, Alexis, Michael N., Skaltsounis, Leandros A.

“…One flavonol glycoside, two O-isoprenylated flavonols, one α,α-dimethylallyl flavonol, one dihydrochalcone, two furanocoumarins and one terpenoid previously…”
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Isoxazole substituted chromans against oxidative stress-induced neuronal damage by Koufaki, Maria, Tsatsaroni, Alexandra, Alexi, Xanthippi, Guerrand, Helène, Zerva, Sofia, Alexis, Michael N.

“…In an effort to optimize our previously identified neuroprotective chroman derivatives, 20 new 2 or 5-substituted chroman analogues bearing isoxazole moieties…”
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Design and synthesis of novel neuroprotective 1,2-dithiolane/chroman hybrids by Koufaki, Maria, Kiziridi, Christina, Alexi, Xanthippi, Alexis, Michael N.

“…Novel 1,2-dithiolane/chroman hybrids bearing heterocyclic rings such as 1,2,4- and 1,3,4-oxadiazole, 1,2,3-triazole and tetrazole were designed and…”
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Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity by Koufaki, Maria, Theodorou, Elissavet, Alexi, Xanthippi, Nikoloudaki, Faidra, Alexis, Michael N.

“…β-Thujaplicin (hinokitiol or 2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one), a natural tropolone, shows numerous activities while its synthetic analogues…”
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Design and synthesis of 1,2-dithiolane derivatives and evaluation of their neuroprotective activity by Koufaki, Maria, Kiziridi, Christina, Nikoloudaki, Faidra, Alexis, Michael N.

“…We designed and synthesized new analogues containing 1,2-dithiolane-3-alkyl and protected or free catechol moieties connected through heteroaromatic rings such…”
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