Search Results - "Alexandrova, L. A."

5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine as inhibitors of viral and bacterial growth by Alexandrova, L. A., Efremenkova, O. V., Andronova, V. L., Galegov, G. A., Solyev, P. N., Karpenko, I. L., Kochetkov, S. N.

“…A series of 5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine have been synthesized by the interaction of…”
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5-Alkyloxymethyl Derivatives of 2ʹ-Deoxyuridine Bearing 2,4-Dinitrophenyl and Dansyl Groups: Synthesis and Antibacterial Activity by Makarov, D. A., Oskolsky, I. A., Jasko, M. V., Solyev, P. N., Vasilyeva, B. F., Demiankova, M. V., Efremenkova, O. V., Kochetkov, S. N., Alexandrova, L. A.

“…Condensation of 3ʹ,5ʹ-di- O -acetyl-5-bromomethyl-2ʹ-deoxyuridine with 6-trifluoroacetylaminohexan1-ol yielded…”
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New perspectives for use of gamma-glutamyltranspeptidase in clinical enzymes tests by Alexandrova, L. A.

“…Gamma-glutamyltranspeptidase (GGTP), isolated from a variety of sources from microorganisms to mammals, including human blood and organs, has been studied…”
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Synthesis and biological properties of pyrimidine 4′-fluoronucleosides and 4′-fluorouridine 5′-O-triphosphate by Ivanov, M. A, Ludva, G. S, Mukovnya, A. V, Kochetkov, S. N, Tunitskaya, V. L, Alexandrova, L. A

“…4′-Fluoro-2′,3′-O-isopropylidenecytidine was synthesized by the treatment of 5′-O-acetyl-4′-fluoro-2′,3′-O-isopropylideneuridine with triazole and…”
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Glycol and Phosphate Depot Forms of 4- and/or 5-Modified Nucleosides Exhibiting Antibacterial Activity by Negrya, S. D., Jasko, M. V., Makarov, D. A., Solyev, P. N., Karpenko, I. L., Shevchenko, O. V., Chekhov, O. V., Glukhova, A. A., Vasilyeva, B. F., Efimenko, T. A., Sumarukova, I. G., Efremenkova, O. V., Kochetkov, S. N., Alexandrova, L. A.

“…Resistance developed to the majority of drugs used to treat infectious diseases warrants the design of new compounds effective against drug-resistant strains…”
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5-Alkylthiomethyl Derivatives of 2'-Deoxyuridine: Synthesis and Antibacterial Activity by Negrya, S. D., Makarov, D. A., Solyev, P. N., Karpenko, I. L., Chekhov, O. V., Glukhova, A. A., Vasilyeva, B. F., Sumarukova, I. G., Efremenkova, O. V., Kochetkov, S. N., Alexandrova, L. A.

“…To obtain nucleoside derivatives with antibacterial activity, we have proposed three ways of the synthesis of 5-alkylthiomethyl-2'-deoxyuridines, which was…”
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4′-C-nucleoside derivatives: Synthesis and antiviral properties by Alexandrova, L. A.

“…Synthesis of 4′-C-modified nucleosides and their derivatives, as well as the structure-activity relationship toward hepatitis C virus were discussed…”
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INTERRELATIONSHIP OF THE MEDIATOR OF ANGIOGENESIS OF VEGF-A WITH GLUTATHIONE METABOLISM PARAMETERS AND THE CLINICAL CHARACTERISTICS OF SYSTEMIC AUTOIMMUNE DISEASES WITH JOINT DAMAGE by Alexandrova, L. A., Filippova, N. A., Iman, A., Subbotina, T. F., Trofimov, V. I.

“…Introduction. In systemic autoimmune diseases with joint damage (SADJD), impaired angiogenesis occurs, which plays a key role in the progression of…”
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The status of erythrocyte glutathione in clinical medicine: reality and possibilities by Alexandrova, L. A.

“…The review examines the current state of free radical oxidation processes in clinical medicine. Based on many years of our research and analysis of the…”
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Development of Liposomal Forms of Modified Pyrimidine Nucleosides and Investigation of Their Antibacterial Properties by Karpenko, I L, Sorokoumova, G M, Sumarukova, I G, Gaydukevich, S K, Zaretskaya, M A, Efremenkova, O V, Alexandrova, L A

“…Different phosphocholine-cardiolipin-2'-deoxyuridine inclusion complexes were developed, that allowed to compose a water-soluble form of nucleoside analogues…”
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New 5-modified pyrimidine nucleoside inhibitors of mycobacterial growth by Alexandrova, L A, Shmalenyuk, E R, Kochetkov, S N, Erokhin, V V, Smirnova, T G, Andreevskaia, S N, Chernousova, L N

“…The WHO has declared tuberculosis (TB) a global health emergency. Therefore, there is an urgent need to discover and develop new anti-TB drugs. Here we report…”
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Content of Total Homocysteine and Major Aminothiols in Rats with Experimental Renal Ischemia by Kuz’menko, N. V., Alexandrova, L. A., Chefu, S. G., Blashko, E. L., Zhloba, A. A., Cirlin, V. A.

“…The contents of total homocysteine, cysteine, and glutathione in blood plasma and tissue of rats with renal ischemia were measured by HPLC. Our study was…”
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Furano- and Pyrrolo [2,3-D] Pyrimidine Nucleosides and Their 5′-O-Triphospates: Synthesis and Enzymatic Activity by Alexandrova, L. A., Ivanov, M. A., Victorova, L. S., Kukhanova, M. K.

“…A series of bicyclic [2,3-d]furano- and pyrrolopyrimidine ribonucleosides were synthesized and converted chemically into corresponding 5′-O-triphosphates…”
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New furano- and pyrrolo[2,3-d]pyrimidine nucleosides and their 5′-O-triphosphates: Synthesis and biological properties by Ivanov, M. A., Ivanov, A. V., Krasnitskaya, I. A., Smirnova, O. A., Karpenko, I. L., Belanov, E. F., Prasolov, V. S., Tunitskaya, V. L., Alexandrova, L. A.

“…Bicyclic furano[2,3- d ]pyrimidine ribonucleosides were synthesized by Pd(0)-and CuI-catalyzed coupling of 5-iodouridine with terminal alkynes. The treatment…”
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Aryl-Containing Esters Of Triphosphoric Acid As Substrates Of Terminal Deoxynucleotidyl Transferase by Khandazhinskaya, A. L., Matyugina, E. S., Alexandrova, L. A., Shirokova, E. A., Kukhanova, M. K., Jasko, M. V.

“…A new group of terminal deoxynucleotidyltransferase (TDT) substrates, namely, non-nucleoside triphosphates (NNTP) bearing 5-substituted 2,4-dinitrophenyl…”
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Structure-functional analysis of interactions of terminal deoxynucleotidyl transferase with new non-nucleoside substrates by Matyugina, E S, Alexandrova, L A, Jas'ko, M V, Ivanov, A V, Vasil'ev, I A, Lapteva, V L, Khandazhinskaya, A L, Kukhanova, M K

“…New non-nucleoside esters of phosphoric acid containing various hydrophobic groups, namely (1) N-(2-tripticencarbonyl)-4-aminobutyl; (2) 5-phenylsubstituted…”
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The previous experience of group art-work at complex hospital treatment of patients with hard psychiatric disorders by V. G. Kosenko, I. V. Khlopina, Yu. G. Poroshin, L. A. Alexandrova, Ye. G. Patrakova, M. G. Dobryakova

“…The article lists brief survey on the history of the art-therapy development. The main features of application of this method of the group psychotherapy with…”
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Base-Modified Ribonucleosides as Potential Anti-Hepatitis C virus Agents by Ivanov, A.V., Smirnova, O.A., Golubeva, N.A., Ivanov, M.A., Tunitskaya, V.L., Shipitsyn, A.V., Alexandrova, L.A.

“…Abstract Four novel series of base modified ribonucleoside analogues were synthesized and evaluated as potential anti-HCV agents. For two compounds notable…”
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2′-Deoxynucleoside 5′-triphosphates modified at α-, β- and γ-phosphates as substrates for DNA polymerases by Alexandrova, Ludmila A., Skoblov, Alexander Yu, Jasko, Maxim V., Victorova, Lyubov S., Krayevsky, Alexander A.

“…Replacement of α-, β- and γ-phosphate groups in 2′-deoxynucleoside 5′-triphosphates (dNTP) with phosphonate groups yields a new set of dNTP mimics with…”
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Development of Liposomal Forms of Modified Pyrimidine Nucleosides and Investigation of Their Antibacterial Properties by I. L. Karpenko, G. M. Sorokoumova, I. G. Sumarukova, S. K. Gaydukevich, M. A. Zaretskaya, Q. V. Efremenkova, L. A. Alexandrova

“…Different phosphocholine-cardlolipin-2'-deoxyuridine inclusion complexes were developed, that allowed to compose a water-soluble form of nucleoside analogues…”
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