Search Results - "Alexandrova, Evguenia M"

p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo by Alexandrova, Evguenia M, Mirza, Safia A, Xu, Sulan, Schulz-Heddergott, Ramona, Marchenko, Natalia D, Moll, Ute M

“…Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their…”
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The HSP-RTK-Akt axis mediates acquired resistance to Ganetespib in HER2-positive breast cancer by Eyermann, Christopher E., Haley, John D., Alexandrova, Evguenia M.

“…Breast cancer is the leading cause of cancer-related death in women worldwide. Human epidermal growth factor receptor 2 (HER2)-positive subtype comprises 20%…”
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ΔN63 suppresses the ability of pregnancy-identified mammary epithelial cells (PIMECs) to drive HER2-positive breast cancer by Eyermann, Christopher E, Li, Jinyu, Alexandrova, Evguenia M

“…While pregnancy is known to reduce a woman's life-long risk of breast cancer, clinical data suggest that it can specifically promote HER2 (human EGF receptor…”
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Correction: p63 suppresses the ability of pregnancy-identified mammary epithelial cells (PIMECs) to drive HER2-positive breast cancer by Eyermann, Christopher E., Li, Jinyu, Alexandrova, Evguenia M.

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p63 suppresses the ability of pregnancy-identified mammary epithelial cells (PIMECs) to drive HER2-positive breast cancer by Eyermann, Christopher E., Li, Jinyu, Alexandrova, Evguenia M.

“…While pregnancy is known to reduce a woman’s life-long risk of breast cancer, clinical data suggest that it can specifically promote HER2 (human EGF receptor…”
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Role of p53 family members p73 and p63 in human hematological malignancies by Alexandrova, Evguenia M., Moll, Ute M.

“…Abstract p53, mutated in over half of human cancers and about 13% of all hematological malignancies, maintains genomic integrity and triggers cellular…”
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Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway by Alexandrova, Evguenia M., Thomsen, Gerald H.

“…The ubiquitin ligase Smurf1 can target a handful of signaling proteins for ubiquitin-mediated proteasomal destruction or functional modification, including…”
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Depleting stabilized GOF mutant p53 proteins by inhibiting molecular folding chaperones: a new promise in cancer therapy by Alexandrova, Evguenia M, Moll, Ute M

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Heat shock factor 1 confers resistance to lapatinib in ERBB2-positive breast cancer cells by Yallowitz, Alisha, Ghaleb, Amr, Garcia, Lucas, Alexandrova, Evguenia M., Marchenko, Natalia

“…Despite success of ERBB2-targeted therapies such as lapatinib, resistance remains a major clinical concern. Multiple compensatory receptor tyrosine kinase…”
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ΔNp63 Regulates Homeostasis, Stemness, and Suppression of Inflammation in the Adult Epidermis by Eyermann, Christopher E, Chen, Xi, Somuncu, Ozge S, Li, Jinyu, Joukov, Alexander N, Chen, Jiang, Alexandrova, Evguenia M

“…The p63 transcription factor is critical for epidermis formation in embryonic development, but its role in the adult epidermis is poorly understood. In this…”
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Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner by Alexandrova, Evguenia M, Xu, Sulan, Moll, Ute M

“…The DNA-alkylating cytotoxic agent cyclophosphamide (CTX) is commonly used in the clinic to treat hematological malignancies like lymphomas and leukemias as…”
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Mutant p53 - Heat Shock Response Oncogenic Cooperation: A New Mechanism of Cancer Cell Survival by Alexandrova, Evguenia M, Marchenko, Natalia D

“…The main tumor suppressor function of p53 as a "guardian of the genome" is to respond to cellular stress by transcriptional activation of apoptosis, growth…”
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Xenopus axin‐related protein: A link between its centrosomal localization and function in the Wnt/β‐catenin pathway by Alexandrova, Evguenia M., Sokol, Sergei Y.

“…The Wnt/β‐catenin signaling pathway regulates cell proliferation and cell fate determination in multiple systems. However, the subcellular localization of Wnt…”
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Generation of p53-deficient induced pluripotent stem cells from mouse embryo fibroblasts by Alexandrova, Evguenia M, Moll, Ute M

“…Here we describe a method for generating induced pluripotent stem (iPS) cells from mouse embryonic fibroblasts (MEFs). Recombinant retroviruses carrying human…”
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The role of the ubiquitin ligase Smurf1 in neural development and cell morphology by Alexandrova, Evguenia M

“…Ubiquitin-dependent protein degradation is an important mechanism to regulate protein function, along with protein synthesis and post-translational…”
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