Search Results - "Alexandrov, Vadim"

Application of the Complex Moments for Selection of an Optimal Sensor by Nigmatullin, Raoul R, Alexandrov, Vadim S

“…In the first time we apply the statistics of the complex moments for selection of an optimal pressure sensor (from the available set of sensors) based on their…”
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A multi-reference poly-conformational method for in silico design, optimization, and repositioning of pharmaceutical compounds illustrated for selected SARS-CoV-2 ligands by Alexandrov, Vadim, Kirpich, Alexander, Kantidze, Omar, Gankin, Yuriy

“…This work presents a novel computational multi-reference poly-conformational algorithm for design, optimization, and repositioning of pharmaceutical compounds…”
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Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder by Brunner, Daniela, Kabitzke, Patricia, He, Dansha, Cox, Kimberly, Thiede, Lucinda, Hanania, Taleen, Sabath, Emily, Alexandrov, Vadim, Saxe, Michael, Peles, Elior, Mills, Alea, Spooren, Will, Ghosh, Anirvan, Feliciano, Pamela, Benedetti, Marta, Luo Clayton, Alice, Biemans, Barbara

“…Autism spectrum disorder comprises several neurodevelopmental conditions presenting symptoms in social communication and restricted, repetitive behaviors. A…”
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SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition by Hanson, Jesse E, La, Hank, Plise, Emile, Chen, Yung-Hsiang, Ding, Xiao, Hanania, Taleen, Sabath, Emily V, Alexandrov, Vadim, Brunner, Dani, Leahy, Emer, Steiner, Pascal, Liu, Lichuan, Scearce-Levie, Kimberly, Zhou, Qiang

“…Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) used for the treatment of cutaneous T cell lymphoma (CTCL) and under…”
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Normal modes for predicting protein motions: A comprehensive database assessment and associated Web tool by Alexandrov, Vadim, Lehnert, Ursula, Echols, Nathaniel, Milburn, Duncan, Engelman, Donald, Gerstein, Mark

“…We carry out an extensive statistical study of the applicability of normal modes to the prediction of mobile regions in proteins. In particular, we assess the…”
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Normal mode analysis of macromolecular motions in a database framework: Developing mode concentration as a useful classifying statistic by Krebs, W. G., Alexandrov, Vadim, Wilson, Cyrus A., Echols, Nathaniel, Yu, Haiyuan, Gerstein, Mark

“…We investigated protein motions using normal modes within a database framework, determining on a large sample the degree to which normal modes anticipate the…”
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GEOLOGICAL MODELLING OF VIKULOVSKAYA SUITE PRODUCTION DEPOSITS by Diana A. Kazanskaya, Vadim M. Alexandrov, Valentina A. Belkina

“…The relevance. The tasks of researching, exploring, assessing oil and gas, designing, field developing are solved on the basis of geological models. Along with…”
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Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures by Alexandrov, Vadim, Gerstein, Mark

“…Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure…”
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High-throughput analysis of behavior for drug discovery by Alexandrov, Vadim, Brunner, Dani, Hanania, Taleen, Leahy, Emer

“…Drug testing with traditional behavioral assays constitutes a major bottleneck in the development of novel therapies. PsychoGenics developed three…”
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Indexing Ultrafast Shape-Based Descriptors in MongoDB to Identify TLR4 Pathway Agonists by Polyakov, Valery R., Alexandrov, Vadim, Maderna, Andreas, Bajjuri, Krishna, Li, Xiaofan, Zhou, Sihong

“…A method is presented for an ultrafast shape-based search workflow for the screening of large compound collections, i.e., those of vendors. The…”
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Novel Efficient Multistage Lead Optimization Pipeline Experimentally Validated for DYRK1B Selective Inhibitors by Alexandrov, Vadim, Vilenchik, Maria, Kantidze, Omar, Tsutskiridze, Nika, Kharchilava, Daviti, Lhewa, Pema, Shishkin, Aleksandr, Gankin, Yuriy, Kirpich, Alexander

“…In addition to general challenges in drug discovery such as the identification of lead compounds in time- and cost-effective ways, specific challenges also…”
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Reprint of: Highthroughtput analysis of behavior for drug discovery by Alexandrov, Vadim, Brunner, Dani, Hanania, Taleen, Leahy, Emer

“…Drug testing with traditional behavioral assays constitutes a major bottleneck in the development of novel therapies. PsychoGenics developed three…”
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Highthroughtput analysis of behavior for drug discovery by Alexandrov, Vadim, Brunner, Dani, Hanania, Taleen, Leahy, Emer

“…Drug testing with traditional behavioral assays constitutes a major bottleneck in the development of novel therapies. PsychoGenics developed three…”
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Pole Placement Optimization for Disturbance Rejection in Discrete-Time Systems by Alexandrov, Vadim

“…The control design problem for LTI SISO discrete time system is considered. The controller that minimizes the load sensitivity function H ∞ norm, subject to…”
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Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice by Alexandrov, Vadim, Brunner, Dani, Menalled, Liliana B, Kudwa, Andrea, Watson-Johnson, Judy, Mazzella, Matthew, Russell, Ian, Ruiz, Melinda C, Torello, Justin, Sabath, Emily, Sanchez, Ana, Gomez, Miguel, Filipov, Igor, Cox, Kimberly, Kwan, Mei, Ghavami, Afshin, Ramboz, Sylvie, Lager, Brenda, Wheeler, Vanessa C, Aaronson, Jeff, Rosinski, Jim, Gusella, James F, MacDonald, Marcy E, Howland, David, Kwak, Seung

“…Analyzing and integrating a broad range of behavioral phenotypes enables prediction of underlying genetic mutations in mouse models of Huntington's disease…”
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The lympro® test: A biomarker for Alzheimer’s disease using blood samples from clinically diagnosed Alzheimer’s disease and cognitively intact subjects by Kirby, Louis, Bier, Colin, Jorgensen, Paul, Alexandrov, Vadim, Sabbagh, Marwan N

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P4‐236: The lympro® test: A biomarker for Alzheimer's disease using blood samples from clinically diagnosed Alzheimer's disease and cognitively intact subjects by Kirby, Louis, Bier, Colin, Jorgensen, Paul, Alexandrov, Vadim, Sabbagh, Marwan N.

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P4‐039: Differences between TG2576‐ and APP/PS1 Mice in High‐Throughput Behavioral Screening Correlates with Differences in Brain Pathology by Hanania, Taleen, Havas, Daniel, Sabath, Emily, Kabitzke, Patricia, Mazella, Matthew, Cox, Kimberly, Berger, Jason, Windisch, Manfred, Brunner, Daniela, Alexandrov, Vadim

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P3‐068: Effects of Treatment With Doxycycline on Behavior, Neuroinflammation and Brain Pathology in the RTG‐4510 Mouse Model by Havas, Daniel, Windisch, Manfred, Kabitzke, Patricia, Sabath, Emily, Thiede, Lucinda, Mazella, Matthew, Brunner, Daniela, Alexandrov, Vadim, Hanania, Taleen

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EFFECTS OF TREATMENT WITH DOXYCYCLINE ON BEHAVIOR, NEUROINFLAMMATION AND BRAIN PATHOLOGY IN THE RTG-4510 MOUSE MODEL by Havas, Daniel, Windisch, Manfred, Kabitzke, Patricia, Sabath, Emily, Thiede, Lucinda, Mazella, Matthew, Brunner, Daniela, Alexandrov, Vadim, Hanania, Taleen

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