Search Results - "Alexandrov, Kroum"

The critical DNA damage by benzo( a)pyrene in lung tissues of smokers and approaches to preventing its formation by Alexandrov, Kroum, Rojas, Margarita, Satarug, Soisungwan

“…Benzo( a)pyrene (BP) and cadmium are environmental pollutants found in foodstuffs, cigarette smoke, and polluted air. BP is converted in liver and lung to…”
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Genetic Polymorphism of CYP Genes, Alone or in Combination, as a Risk Modifier of Tobacco-related Cancers by BARTSCH, H, NAIR, U, RISCH, A, ROJAS, M, WIKMAN, H, ALEXANDROV, K

“…Tobacco use is causally associated with cancers of the lung, larynx, mouth, esophagus, kidneys, urinary tract, and possibly, breast. Major classes of…”
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Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers by Bartsch, H, Rojas, M, Nair, U, Nair, J, Alexandrov, K

“…Preventive strategies require identification of cancer-susceptible individuals resulting from combinations of carcinogen exposure, cancer-predisposing genes,…”
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DNA damage by benzo(a)pyrene in human cells is increased by cigarette smoke and decreased by a filter containing rosemary extract, which lowers free radicals by ALEXANDROV, Kroum, ROJAS, Margarita, ROLANDO, Christian

“…We found previously that the human lung benzo(a)pyrene (BP)-7,8-diol-9,10-epoxide-N(2)-deoxyguanosine (BPDE-dG) adduct concentrate in the target bronchial…”
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CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation by Alexandrov, Kroum, Cascorbi, Ingolf, Rojas, Margarita, Bouvier, Guy, Kriek, Erik, Bartsch, Helmut

“…Benzo[a]pyrene diol epoxide (BPDE)–DNA adducts are involved in the induction of p53 mutations and probably in the causation of human lung cancer associated…”
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Polycyclic aromatic hydrocarbon-DNA adducts in humans: relevance as biomarkers for exposure and cancer risk by Kriek, E, Rojas, M, Alexandrov, K, Bartsch, H

“…The methodology applied for DNA adducts in humans has become more reliable in recent years, allowing to detect even background carcinogenic adduct levels in…”
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Modulation of benzo[a]pyrene diolepoxide–DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism by Rojas, Margarita, Cascorbi, Ingolf, Alexandrov, Kroum, Kriek, Erik, Auburtin, Guy, Mayer, Lucienne, Kopp-Schneider, Annette, Roots, Ivar, Bartsch, Helmut

“…The modulation of benzo[a]pyrene diolepoxide (BPDE)–DNA adduct levels by polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes was assessed in leukocytes of…”
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High DNA damage by benzo[a]pyrene 7,8-diol-9,10-epoxide in bronchial epithelial cells from patients with lung cancer: comparison with lung parenchyma by Rojas, Margarita, Marie, Beatrice, Vignaud, Jean Michel, Martinet, Nadine, Siat, Joëlle, Grosdidier, Gilles, Cascorbi, Ingolf, Alexandrov, Kroum

“…In the present study, the level of benzo[a]pyrene 7,8-diol-9,10-epoxide-N 2-deoxyguanosine (BPDE-N 2-dG) in normal bronchial epithelial cells from…”
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An improved fluorometric assay for dosimetry of benzo(a)pyrene diol-epoxide-DNA adducts in smokers' lung : comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity by ALEXANDROV, K, ROJAS, M, GENESTE, O, CASTEGNARO, M, CAMUS, A.-M, PETRUZZELLI, S, GIUNTINI, C, BARTSCH, H

“…An improved high-performance liquid chromatography/fluorometric assay has been established to quantitate the benzo(a)pyrene (BP) tetrols released after acid…”
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Myeloperoxidase – 463A variant reduces benzo[a]pyrene diol epoxide DNA adducts in skin of coal tar treated patients by Rojas, Margarita, Godschalk, Roger, Alexandrov, Kroum, Cascorbi, Ingolf, Kriek, Erik, Ostertag, Judith, Van Schooten, Frederik-Jan, Bartsch, Helmut

“…The skin of atopic dermatitis patients provides an excellent model to study the role of inflammation in benzo[a]pyrene (BaP) activation, since these…”
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Evidence of anti-benzo[a]pyrene diolepoxide-DNA adduct formation in human colon mucosa by Alexandrov, Kroum, Rojas, Margarita, Kadlubar, Fred F., Lang, Nicholas P., Bartsch, Helmut

“…As risk factors for colorectal cancer include consumption of foods potentially contaminated with polycyclic aromatic hydrocarbons (PAHs), the level of ( +…”
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Anti-benzo[a]pyrene diolepoxide--DNA adduct levels in peripheral mononuclear cells from coke oven workers and the enhancing effect of smoking by Rojas, M, Alexandrov, K, Auburtin, G, Wastiaux-Denamur, A, Mayer, L, Mahieu, B, Sebastien, P, Bartsch, H

“…The level of (+/-)-r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) bound to DNA of lymphocytes plus monocytes in 39 coke oven…”
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Cancer biomarkers in human atherosclerotic lesions: detection of DNA adducts by Izzotti, A, De Flora, S, Petrilli, G L, Gallagher, J, Rojas, M, Alexandrov, K, Bartsch, H, Lewtas, J

“…Since somatic mutations are suspected to contribute to the pathogenesis not only of cancer but also of atherosclerotic plaques, we measured DNA adducts in the…”
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Carcinogen Metabolism in Human Lung Tissues and the Effect of Tobacco Smoking: Results from a Case-Control Multicenter Study on Lung Cancer Patients by Bartsch, Helmut, Petruzzelli, Stefano, Flora, Silvio De, Hietanen, Eino, Camus, Anne-Marie, Castegnaro, Marcel, Alexandrov, Kroum, Rojas, Margarita, Saracci, Rodolfo, Giuntini, Carlo

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Differences in the DNA adducts formed in cultured rabbit and rat dermal fibroblasts by benzo(a)pyrene and (-)benzo(a)pyrene-7,8-diol by ALEXANDROV, K, SALA, M, ROJAS, M

“…Benzo(a)pyrene (BaP) is highly carcinogenic in rats but is without effect in rabbits when administered s.c. The possibility that BaP-DNA adducts could be…”
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Validation of a new fluorometric assay for benzo[a]pyrene diolepoxide-DNA adducts in human white blood cells: comparisons with 32P-postlabeling and ELISA by Rojas, M, Alexandrov, K, van Schooten, F J, Hillebrand, M, Kriek, E, Bartsch, H

“…A new fluorometric assay was validated for quantification of benzo[a]pyrene diolepoxide (BPDE)-DNA adducts in white blood cells (WBC) from humans exposed to…”
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Carcinogen Metabolism in Human Lung Tissues and the Effect of Tobacco Smoking: Results from a Case-Control Multicenter Study on Lung Cancer Patients by Bartsch, Helmut, Petruzzelli, Stefano, De Flora, Silvio, Hietanen, Eino, Camus, Anne-Marie, Castegnaro, Marcel, Alexandrov, Kroum, Rojas, Margarita, Saracci, Rodolfo, Giuntini, Carlo

“…Cigarette smoking is the strongest risk factor for lung cancer, but genetically determined variations in the activities of pulmonary enzyme that metabolize…”
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Metabolism of benzo[a]pyrene by brain microsomes of fetal and adult rats and mice. Induction by 5,6 benzoflavone, comparison with liver and lung microsomal activities by Rouet, P, Alexandrov, K, Markovits, P, Frayssinet, C, Dansette, P M

“…Using brain, lung and liver microsomes as the enzyme source in in vitro assays, benzo[a]pyrene (B[a]P) metabolism was studied in fetuses and dams of mice…”
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The binding of benzo[a]pyrene to mouse and rat skin DNA by Baer-Dubowska, W, Alexandrov, K

“…The covalently bound products of[3H]benzo[a]pyrene (BP) were determined in the DNA from the skin of mice and rats. While the total binding to DNA of rat skin…”
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Microsome-dependent binding of benzo(alpha)pyrene and aflatoxin B1 to DNA, and benzo(alpha)pyrene binding to aflatoxin-conjugated DNA by Alexandrov, K, Frayssinet, C

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