Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction

Highlights • Sepsis induces neuroinflammation, endothelial dysfunction and cognitive decline in mice; • Statins prevent cognitive impairment after sepsis independent of changes in survival; • Statins treatment modulate neuroinflammation after septic challenge; • Statins protect brain microcirculatio...

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Bibliographic Details
Published in:	Brain, behavior, and immunity Vol. 60; pp. 293 - 303
Main Authors:	Reis, Patricia A, Alexandre, Pedro C.B, D’Avila, Joana C, Siqueira, Luciana D, Antunes, Barbara, Estato, Vanessa, Tibiriça, Eduardo V, Verdonk, Franck, Sharshar, Tarek, Chrétien, Fabrice, Castro-Faria-Neto, Hugo C, Bozza, Fernando A
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-02-2017
Subjects:	Allergy and Immunology Cognition Endothelium Neuroinflammation Psychiatry Sepsis Statin Sepsis Neuroinflammation Cognition Statin Endothelium
Online Access:	Get full text
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Summary:	Highlights • Sepsis induces neuroinflammation, endothelial dysfunction and cognitive decline in mice; • Statins prevent cognitive impairment after sepsis independent of changes in survival; • Statins treatment modulate neuroinflammation after septic challenge; • Statins protect brain microcirculation during sepsis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.11.006