Search Results - "Alexandre, P.A."

Humanized hemato-lymphoid system mice by Theocharides, Alexandre P A, Rongvaux, Anthony, Fritsch, Kristin, Flavell, Richard A, Manz, Markus G

“…Over the last decades, incrementally improved xenograft mouse models, supporting the engraftment and development of a human hemato-lymphoid system, have been…”
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Pharmacological DNA demethylation restores SMAD1 expression and tumor suppressive signaling in diffuse large B-cell lymphoma by Stelling, Anna, Wu, Cheuk-Ting, Bertram, Katrin, Hashwah, Hind, Theocharides, Alexandre P.A., Manz, Markus G., Tzankov, Alexandar, Müller, Anne

“…The sphingosine-1-phosphate (S1P) receptor S1PR2 and its downstream adaptor Gα13 are recurrently mutationally inactivated in the germinal center B-cell subtype…”
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A hierarchical neural model in short-term load forecasting by Carpinteiro, Otavio A.S, Reis, Agnaldo J.R, da Silva, Alexandre P.A

“…This paper proposes a novel neural model to the problem of short-term load forecasting (STLF). The neural model is made up of two self-organizing map (SOM)…”
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Sensitive Quantitative Proteomics of Human Hematopoietic Stem and Progenitor Cells by Data-independent Acquisition Mass Spectrometry[S] by Amon, Sabine, Meier-Abt, Fabienne, Gillet, Ludovic C., Dimitrieva, Slavica, Theocharides, Alexandre P.A., Manz, Markus G., Aebersold, Ruedi

“…To date, technical limitations have precluded the robust quantitative proteomic analysis of rare cell types. We describe a highly sensitive mass…”
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Editorial: The therapeutic inhibition of macrophage checkpoints by Theocharides, Alexandre P A, Hutter, Gregor, Saito, Yasuyuki

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Candida albicans -Induced NETosis Is Independent of Peptidylarginine Deiminase 4 by Guiducci, Eva, Lemberg, Christina, Küng, Noëmi, Schraner, Elisabeth, Theocharides, Alexandre P A, LeibundGut-Landmann, Salomé

“…Neutrophils are the most abundant innate immune cells and the first line of defense against many pathogenic microbes, including the human fungal pathogen …”
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Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model by Lysenko, Veronika, Schürch, Patrick M., Tuzlak, Selma, van Wijk, Nicole Wildner-Verhey, Kovtonyuk, Larisa V., Becher, Burkhard, Manz, Markus G., Kreutmair, Stefanie, Theocharides, Alexandre P. A.

“…Polycythemia vera (PV) is a hematopoietic stem cell neoplasm driven by somatic mutations in JAK2 , leading to increased red blood cell (RBC) production…”
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Baseline creatinine predicts acute kidney injury during intensive therapy in transplant‐eligible patients with acute myeloid leukaemia by Krieg, Stefan, Seeger, Harald, Hofmann, Patrick, Del Prete, Carmen, Manz, Markus G., Müller, Antonia M., Theocharides, Alexandre P. A.

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Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria by Halloy, François, Iyer, Pavithra S, Ghidini, Alice, Lysenko, Veronika, Barman-Aksözen, Jasmin, Grubenmann, Chia-Pei, Jucker, Jessica, Wildner-Verhey van Wijk, Nicole, Ruepp, Marc-David, Minder, Elisabeth I, Minder, Anna-Elisabeth, Schneider-Yin, Xiaoye, Theocharides, Alexandre P A, Schümperli, Daniel, Hall, Jonathan

“…Erythropoietic protoporphyria (EPP) is a rare disease in which patients experience severe light sensitivity. It is caused by a deficiency of ferrochelatase…”
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Bone marrow haematopoiesis in patients with COVID-19 by Marques-Maggio, Ewerton, Maccio, Umberto, Marx, Alexandra, Galli, Serena, Schwab, Nathalie, Frank, Angela, Hamelin, Baptiste, Varga, Zsuzsanna, Nombela-Arrieta, César, Mertz, Kirsten D, Theocharides, Alexandre Pa, Koelzer, Viktor H

“…Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection broadly affects organ homeostasis, including the haematopoietic system. Autopsy…”
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Delivery of oligonucleotides to bone marrow to modulate ferrochelatase splicing in a mouse model of erythropoietic protoporphyria by Halloy, François, Iyer, Pavithra S, Ćwiek, Paulina, Ghidini, Alice, Barman-Aksözen, Jasmin, Wildner-Verhey van Wijk, Nicole, Theocharides, Alexandre P A, Minder, Elisabeth I, Schneider-Yin, Xiaoye, Schümperli, Daniel, Hall, Jonathan

“…Abstract Erythropoietic protoporphyria (EPP) is a rare genetic disease in which patients experience acute phototoxic reactions after sunlight exposure. It is…”
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Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts by Theocharides, Alexandre P A, Jin, Liqing, Cheng, Po-Yan, Prasolava, Tatiana K, Malko, Andrei V, Ho, Jenny M, Poeppl, Armando G, van Rooijen, Nico, Minden, Mark D, Danska, Jayne S, Dick, John E, Wang, Jean C Y

“…Although tumor surveillance by T and B lymphocytes is well studied, the role of innate immune cells, in particular macrophages, is less clear. Moreover, the…”
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Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis by Wildschut, Mattheus H. E., Mena, Julien, Dördelmann, Cyril, van Oostrum, Marc, Hale, Benjamin D., Settelmeier, Jens, Festl, Yasmin, Lysenko, Veronika, Schürch, Patrick M., Ring, Alexander, Severin, Yannik, Bader, Michael S., Pedrioli, Patrick G. A., Goetze, Sandra, van Drogen, Audrey, Balabanov, Stefan, Skoda, Radek C., Lopes, Massimo, Wollscheid, Bernd, Theocharides, Alexandre P. A., Snijder, Berend

“…Myelofibrosis is a hematopoietic stem cell disorder belonging to the myeloproliferative neoplasms. Myelofibrosis patients frequently carry driver mutations in…”
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Finally: development of humanized lymph nodes by Theocharides, Alexandre P. A., Manz, Markus G.

“…Overexpression of mouse thymic-stromal-cell-derived lymphopoietin in immune-compromised mice that harbor a reconstituted human immune system rescues lymph node…”
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Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells by Mueller, Jan, Schimmer, Roman R, Koch, Christian, Schneiter, Florin, Fullin, Jonas, Lysenko, Veronika, Pellegrino, Christian, Klemm, Nancy, Russkamp, Norman, Myburgh, Renier, Volta, Laura, Theocharides, Alexandre PA, Kurppa, Kari J, Ebert, Benjamin L, Schroeder, Timm, Manz, Markus G, Boettcher, Steffen

“…TP53 -mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical…”
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Calreticulin mutations affect its chaperone function and perturb the glycoproteome by Schürch, Patrick M, Malinovska, Liliana, Hleihil, Mohammad, Losa, Marco, Hofstetter, Mara C, Wildschut, Mattheus H E, Lysenko, Veronika, Lakkaraju, Asvin K K, Maat, Christina A, Benke, Dietmar, Aguzzi, Adriano, Wollscheid, Bernd, Picotti, Paola, Theocharides, Alexandre P A

“…Calreticulin (CALR) is an endoplasmic reticulum (ER)-retained chaperone that assists glycoproteins in obtaining their structure. CALR mutations occur in…”
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Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency by Theocharides, Alexandre P.A., Lundberg, Pontus, Lakkaraju, Asvin K.K., Lysenko, Veronika, Myburgh, Renier, Aguzzi, Adriano, Skoda, Radek C., Manz, Markus G.

“…The pathogenesis of acquired myeloperoxidase (MPO) deficiency, a rare phenomenon observed in patients with Philadelphia chromosome-negative myeloproliferative…”
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The sympathomimetic agonist mirabegron did not lower JAK2 -V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14 by Drexler, Beatrice, Passweg, Jakob R, Tzankov, Alexandar, Bigler, Martin, Theocharides, Alexandre Pa, Cantoni, Nathan, Keller, Peter, Stussi, Georg, Ruefer, Axel, Benz, Rudolf, Favre, Geneviève, Lundberg, Pontus, Nienhold, Ronny, Fuhrer, Andrea, Biaggi, Christine, Manz, Markus G, Bargetzi, Mario, Mendez-Ferrer, Simon, Skoda, Radek C

“…The β-3 sympathomimetic agonist BRL37344 restored nestin-positive cells within the stem cell niche, and thereby normalized blood counts and improved…”
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Editorial: Advances in Human Immune System Mouse Models for Studying Human Hematopoiesis and Cancer Immunotherapy by Saito, Yasuyuki, Willinger, Tim, Theocharides, Alexandre P A

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Next Generation Humanized Mice Support Engraftment of Myelofibrosis CD34+ Cells by Theocharides, Alexandre P.A., Müller, Rouven, Saito, Yasuyuki, Flavell, Richard A., Manz, Markus G.

“…Introduction While the key transforming genetic events occur in the developing cancerous cell, this cell is dependent on its environmental context and…”
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